A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2.

scientific article

A plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.4452
P932PMC publication ID4695137
P698PubMed publication ID26188124
P5875ResearchGate publication ID280115939

P50authorDong ZhangQ59687621
P2093author name stringKhosrow Rezvani
Hongmin Wang
Ammara Abdullah
Sanam Sane
Jessica L Freeling
Kate A Branick
P2860cites workThe UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic functionQ24305086
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humansQ27934997
Activation of p53 and the pro-apoptotic p53 target gene PUMA during depolarization-induced apoptosis of chromaffin cellsQ28268239
Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancerQ28274188
UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptorsQ28507709
Sp1 expression regulates lung tumor progression.Q30524654
Apoptosis induced by staurosporine alters chaperone and endoplasmic reticulum proteins: Identification by quantitative proteomicsQ33293118
Signaling pathways in early onset sporadic breast cancer of patients in Indonesia.Q33374250
Mortalin/GRP75 binds to complement C9 and plays a role in resistance to complement-dependent cytotoxicityQ33652205
Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cellsQ33772604
Where do we stand with 5-fluorouracil?Q33800905
Immuno nanoparticles integrated electrical control of targeted cancer cell development using whole cell bioelectronic deviceQ33935492
Differences in integrin expression and signaling within human breast cancer cellsQ33959863
Association of TP53 mutational status and gender with survival after adjuvant treatment for stage III colon cancer: results of CALGB 89803Q34004105
Identification and functional characterization of nuclear mortalin in human carcinogenesis.Q34138936
Detecting treatment response in a model of human breast adenocarcinoma using hyperpolarised [1-13C]pyruvate and [1,4-13C2]fumarateQ34344210
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trialQ46570394
Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.Q46581064
Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stressQ46970679
Elevated levels of mortalin expression in human brain tumors.Q48570877
Epidemiology of colorectal cancerQ56994980
Withanone binds to mortalin and abrogates mortalin–p53 complex: Computational and experimental evidenceQ59192509
p53 expression measured by flow cytometry. A comparison of three monoclonal antibodies and the relationship with grade and DNA ploidy in breast cancerQ71729258
Mortalin is over-expressed by colorectal adenocarcinomas and correlates with poor survivalQ80976046
Crosstalk between Raf/MEK/ERK and PI3K/AKT in suppression of Bax conformational change by Grp75 under glucose deprivation conditionsQ85028293
Ubiquitin-associated (UBA) domain in human Fas associated factor 1 inhibits tumor formation by promoting Hsp70 degradationQ34372429
Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapyQ35092706
Vinblastine-induced apoptosis is mediated by discrete alterations in subcellular location, oligomeric structure, and activation status of specific Bcl-2 family membersQ35160453
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasisQ35819806
Intrinsic tumour suppressionQ35953133
Low expression of chloride channel accessory 1 predicts a poor prognosis in colorectal cancerQ36302699
Establishment of a human colorectal cancer cell line P6C with stem cell properties and resistance to chemotherapeutic drugsQ36907415
Vitamin D signalling pathways in cancer: potential for anticancer therapeuticsQ36919979
Hypotensive natural products: current statusQ37232741
A mortalin/HSPA9-mediated switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinaseQ37264396
Cytoplasmic functions of the tumour suppressor p53.Q37466228
Targeting GRP75 improves HSP90 inhibitor efficacy by enhancing p53-mediated apoptosis in hepatocellular carcinomaQ37490724
Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53-Mortalin interactions in colon cancer cellsQ37680211
RETRACTED ARTICLE: JNK confers 5-fluorouracil resistance in p53-deficient and mutant p53-expressing colon cancer cells by inducing survival autophagyQ37702749
Mitochondria: a promising target for anticancer alkaloidsQ38131568
Targeting cancer stem cells to suppress acquired chemotherapy resistanceQ38149736
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.Q38188352
Colon cancer: cancer stem cells markers, drug resistance and treatmentQ38280180
Overexpression of Mortalin in hepatocellular carcinoma and its relationship with angiogenesis and epithelial to mesenchymal transitionQ39067007
Induction of mutant p53-dependent apoptosis in human hepatocellular carcinoma by targeting stress protein mortalin.Q39619016
Tumor suppression by apoptotic and anti-angiogenic effects of mortalin-targeting adeno-oncolytic virusQ39684064
Dual mechanisms of sHA 14-1 in inducing cell death through endoplasmic reticulum and mitochondria.Q39832035
Gender differences in colorectal cancer incidence, mortality, hospitalizations and surgical procedures in CanadaQ40097375
A more efficient RNAi inducible system for tight regulation of gene expression in mammalian cells and xenograft animalsQ40110405
Stress chaperones, mortalin, and pex19p mediate 5-aza-2' deoxycytidine-induced senescence of cancer cells by DNA methylation-independent pathway.Q40153665
Activation of wild type p53 function by its mortalin-binding, cytoplasmically localizing carboxyl terminus peptides.Q40370477
Mortalin imaging in normal and cancer cells with quantum dot immuno-conjugatesQ40598658
Contribution of functional voltage‐gated Na+ channel expression to cell behaviors involved in the metastatic cascade in rat prostate cancer: I. lateral motilityQ40653900
Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cellsQ40811052
Effects of voltage-gated ion channel modulators on rat prostatic cancer cell proliferation: comparison of strongly and weakly metastatic cell linesQ40872588
Induction of apoptosis in prostatic tumor cell line DU145 by staurosporine, a potent inhibitor of protein kinasesQ41182268
Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.Q41198220
MKT-077, a novel rhodacyanine dye in clinical trials, exhibits anticarcinoma activity in preclinical studies based on selective mitochondrial accumulation.Q41235761
Veratridine induces apoptotic death in bovine chromaffin cells through superoxide productionQ41823292
Evaluating new therapies in gastrointestinal stromal tumor using in vivo molecular optical imagingQ41963175
Superoxide anions mediate veratridine-induced cytochrome c release and caspase activity in bovine chromaffin cellsQ42620684
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member.Q42825164
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function.Q42832610
Topiramate and phenytoin anti-immobility effect in the mice forced swimming test is reversed by veratrine: Implication for bipolar depression treatmentQ43297492
Breast tumor immunophenotype of BRCA1-mutation carriers is influenced by age at diagnosisQ43670876
Resistance of colon cancer cells to long-term 5-fluorouracil exposure is correlated to the relative level of Bcl-2 and Bcl-X(L) in addition to Bax and p53 statusQ43938032
Differential cytostatic and apoptotic effects of ecteinascidin-743 in cancer cells. Transcription-dependent cell cycle arrest and transcription-independent JNK and mitochondrial mediated apoptosis.Q44116130
Src activation regulates anoikis in human colon tumor cell linesQ44208143
Mortalin is a prognostic factor of gastric cancer with normal p53 functionQ44263599
Chromosome copy number analysis in screening for prognosis-related genomic regions in colorectal carcinomaQ44868614
P433issue27
P407language of work or nameEnglishQ1860
P304page(s)23561-23581
P577publication date2015-09-01
P1433published inOncotargetQ1573155
P1476titleA plant alkaloid, veratridine, potentiates cancer chemosensitivity by UBXN2A-dependent inhibition of an oncoprotein, mortalin-2
P478volume6

Reverse relations

cites work (P2860)
Q36190104Nucleocytoplasmic Translocation of UBXN2A Is Required for Apoptosis during DNA Damage Stresses in Colon Cancer Cells.
Q37625726Relevance of mortalin to cancer cell stemness and cancer therapy.
Q36674097Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy
Q28069036UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer
Q58766271UBXN2A enhances CHIP-mediated proteasomal degradation of oncoprotein mortalin-2 in cancer cells

Search more.