Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization

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Signaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.399576
P8608Fatcat IDrelease_6yhyiiyqnbgwxduz3x5pygghqi
P932PMC publication ID3504770
P698PubMed publication ID23055517

P2093author name stringRakesh Kumar
Suresh B Pakala
Vasudha S Nair
Sirigiri DivijendraNatha Reddy
P2860cites workAurora B regulates MCAK at the mitotic centromereQ24307822
p21-activated kinase 1 regulates microtubule dynamics by phosphorylating tubulin cofactor BQ24522681
Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cellsQ24536196
p41-Arc subunit of human Arp2/3 complex is a p21-activated kinase-1-interacting substrateQ24537116
Regulation of localization and activity of the microtubule depolymerase MCAKQ24614530
Mitotic centromere-associated kinesin is important for anaphase chromosome segregationQ24670465
The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.Q24679500
A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilizationQ24685169
Vascular endothelial growth factor up-regulation via p21-activated kinase-1 signaling regulates heregulin-beta1-mediated angiogenesisQ28145115
p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer CellsQ28207743
Molecular dissection of the microtubule depolymerizing activity of mitotic centromere-associated kinesinQ28207897
p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cellsQ28216558
Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organizationQ28569064
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLCQ28574525
Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosisQ28633869
Biology of the p21-activated kinasesQ29616035
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activityQ30312108
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its functionQ30444314
Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylationQ30445470
Mammalian mitotic centromere-associated kinesin (MCAK): a new molecular target of sulfoquinovosylacylglycerols novel antitumor and immunosuppressive agentsQ31163475
Microtubule growth activates Rac1 to promote lamellipodial protrusion in fibroblastsQ33880071
Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A.Q34026716
MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachmentQ34267263
Regulation of microtubule destabilizing activity of Op18/stathmin downstream of Rac1.Q34279810
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.Q34462480
PLK1 phosphorylates mitotic centromere-associated kinesin and promotes its depolymerase activityQ34509576
Mitotic centromere-associated kinesin (MCAK): a potential cancer drug target.Q35764416
Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cellsQ36235929
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarityQ36739939
Targeting group II PAKs in cancer and metastasisQ37374517
Functional and spatial regulation of mitotic centromere-associated kinesin by cyclin-dependent kinase 1.Q39718774
Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosisQ42914663
Vav1 couples T cell receptor to serum response factor-dependent transcription via a MEK-dependent pathwayQ43891668
Rac-induced increase of phosphorylation of myosin regulatory light chain in HeLa cellsQ44898329
GPS: a novel group-based phosphorylation predicting and scoring method.Q45157343
Suppression of Rac activity induces apoptosis of human glioma cells but not normal human astrocytes.Q48641568
K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assemblyQ48661634
Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells.Q53455909
Nonredundant functions of Kinesin-13s during meiotic spindle assembly.Q53552320
Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer CellsQ57980204
P4510describes a project that usesImageJQ1659584
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages10
P304page(s)40560-40569
P577publication date2012-10-10
P1433published inJournal of Biological ChemistryQ867727
P1476titleSignaling-dependent phosphorylation of mitotic centromere-associated kinesin regulates microtubule depolymerization and its centrosomal localization
P478volume287

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cites work (P2860)
Q47094397A Cdk1 phosphomimic mutant of MCAK impairs microtubule end recognition
Q33618830Anti-cancer effect of novel PAK1 inhibitor via induction of PUMA-mediated cell death and p21-mediated cell cycle arrest
Q30656511Cdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.
Q51411634Deficiency of RITA results in multiple mitotic defects by affecting microtubule dynamics.
Q38856254Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells
Q38825915Molecular insight into the regulation and function of MCAK.
Q99630289P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer
Q30583150Rac1 and Aurora A regulate MCAK to polarize microtubule growth in migrating endothelial cells
Q28261026Small molecule inhibition of group I p21-activated kinases in breast cancer induces apoptosis and potentiates the activity of microtubule stabilizing agents
Q30658815Spatiotemporal dynamics of Aurora B-PLK1-MCAK signaling axis orchestrates kinetochore bi-orientation and faithful chromosome segregation.
Q38779105Structure, biochemistry, and biology of PAK kinases
Q27302867The KLP-7 Residue S546 Is a Putative Aurora Kinase Site Required for Microtubule Regulation at the Centrosome in C. elegans
Q41694208The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1

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