Mitoxantrone-induced DNA damage in leukemia cells is enhanced by treatment with high-dose arabinosylcytosine

scientific article

Mitoxantrone-induced DNA damage in leukemia cells is enhanced by treatment with high-dose arabinosylcytosine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/BF00273412
P698PubMed publication ID3165725

P2093author name stringW Plunkett
V Heinemann
D Murray
R E Meyn
R Walters
P2860cites workHigh-dose cytosine arabinoside: treatment and cellular pharmacology of chronic myelogenous leukemia blast crisisQ33452103
A pilot study of high-dose 1-beta-D-arabinofuranosylcytosine for acute leukemia and refractory lymphoma: clinical response and pharmacology.Q33483006
Application of arabinofuranosyl cytosine in the kinetic analysis and quantitation of DNA repair in human cells after ultraviolet irradiationQ34252372
Applicability of the alkaline elution procedure as modified for the measurement of DNA damage and its repair in nonradioactively labeled cellsQ35074646
Improved microfluorometric DNA determination in biological material using 33258 HoechstQ36895188
NADPH cytochrome P-450 reductase activation of quinone anticancer agents to free radicalsQ37316864
Kinetics of Inhibition of Deoxynucleotide-Polymerizing Enzyme Activities from Normal and Leukemic Human Cells by 9-beta-D-Arabinofuranosyladenine 5'-Triphosphate and 1-beta-D-Arabinofuranosylcytosine 5'-TriphosphateQ40661875
Phase I-II clinical and pharmacologic studies of high-dose cytosine arabinoside in refractory leukemiaQ40805621
The effect of cytosine arabinoside on the frequency of single-strand breaks in DNA of mammalian cells following irradiation or chemical treatmentQ41290809
Saturation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate accumulation in leukemia cells during high-dose 1-beta-D-arabinofuranosylcytosine therapyQ41324222
Experimental antitumor activity of aminoanthraquinonesQ41487334
High-dose cytosine arabinoside and mitoxantrone: a highly effective regimen in refractory acute myeloid leukemiaQ42216165
High-dose cytosine arabinoside therapy for refractory leukemiaQ42244165
DNA-binding specificity and RNA polymerase inhibitory activity of bis(aminoalkyl)anthraquinones and bis(methylthio)vinylquinolinium iodidesQ42262844
Relationship between cytotoxicity and DNA damage in mammalian cells treated with anthracenedione derivativesQ45283553
Treatment of poor risk acute leukemia with sequential high-dose ARA-C and asparaginase.Q53553679
Mitozantrone-induced toxicity and DNA strand breaks in leukaemic cells.Q54415532
Interactions of a new antitumor agent, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-9,10-anthracenedione, with nucleic acidsQ62590663
Schedule-dependent synergism for the combination of 1-beta-D-arabinofuranosylcytosine and daunorubicinQ69733644
Phase I-II trial of mitoxantrone in acute leukemiaQ69832560
Mitozantrone and high-dose cytarabine in refractory adult acute myeloid leukaemiaQ69868917
The antitumor agent mitoxantrone binds cooperatively to DNA: evidence for heterogeneity in DNA conformationQ69879901
Mitoxantrone affects topoisomerase activities in human breast cancer cellsQ70139548
Mitoxantrone as a single agent and in combination chemotherapy in patients with refractory acute leukemiaQ70385124
The efficiency of DNA strand-break repair in two fibrosarcoma tumors and in normal tissues of mice irradiated in vivo with X raysQ70391667
Variation in normal and tumor tissue sensitivity of mice to ionizing radiation-induced DNA strand breaks in vivoQ71096758
Lethal effects of 1-beta-D-arabinofuranosylcytosine incorporation into deoxyribonucleic acid during ultraviolet repairQ71280277
Correlation of cytotoxicity with incorporation of ara-C into DNAQ71302520
Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopyQ71306385
DNA strand breaks caused by inhibitors of DNA synthesis: 1-beta-D-arabinofuranosylcytosine and aphidicolinQ71614063
Studies in mouse L-cells on the incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and on inhibition of DNA polymerase by 1-beta-D-arabinofuranosylcytosine 5'-triphosphateQ71726732
Phase II trial of mitoxantrone in refractory acute leukemiaQ71733423
Accumulation of leukemic cell DNA strand breaks with adriamycin and cytosine arabinosideQ71745518
Quantitation of 1-beta-D-arabinofuranosylcytosine 5'-triphosphate in the leukemic cells from bone marrow and peripheral blood of patients receiving 1-beta-D-arabinofuranosylcytosine therapyQ71998653
Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenineQ72310743
Fluorometric quantitation of single-stranded DNA: A method applicable to the technique of alkaline elutionQ72691303
Enhancement of the DNA breakage and cytotoxic effects of intercalating agents by treatment with sublethal doses of 1-beta-D-arabinofuranosylcytosine or hydroxyurea in L1210 cellsQ72750026
P433issue3
P921main subjectDNA damageQ5205747
P304page(s)205-210
P577publication date1988-01-01
P1433published inCancer Chemotherapy and PharmacologyQ326137
P1476titleMitoxantrone-induced DNA damage in leukemia cells is enhanced by treatment with high-dose arabinosylcytosine
P478volume22

Reverse relations

cites work (P2860)
Q41843895Assessment of Drug Sensitivity in Hematopoietic Stem and Progenitor Cells from Acute Myelogenous Leukemia and Myelodysplastic Syndrome Ex Vivo
Q73209536Dose-escalation study of single dose mitoxantrone in combination with timed sequential chemotherapy in patients with refractory or relapsing acute myelogenous leukemia
Q73269119Early secondary acute myelogenous leukemia in breast cancer patients after treatment with mitoxantrone, cyclophosphamide, fluorouracil and radiation therapy
Q62022698FLANG salvage chemotherapy is an effective regimen that offers a safe bridge to transplantation for patients with relapsed or refractory acute myeloid leukemia
Q41132585Lack of involvement of reactive oxygen in the cytotoxicity of mitoxantrone, CI941 and ametantrone in MCF-7 cells: comparison with doxorubicin
Q48724165Mitoxantrone-induced DNA strand breaks in cell-cultures of malignant human astrocytoma and glioblastoma tumors
Q36657495Mitoxantrone. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in the chemotherapy of cancer
Q41120664Mitoxantrone: a review of its pharmacological properties and use in acute nonlymphoblastic leukaemia
Q34288371Nucleoside analogues: mechanisms of drug resistance and reversal strategies.
Q54220320Quantification of topoisomerase-DNA complexes in leukemia cells from patients undergoing therapy with a topoisomerase-directed agent.
Q36761725Timed-sequential chemotherapy as induction and/or consolidation regimen for younger adults with acute myelogenous leukemia
Q41055118Treatment of childhood acute myeloid leukaemia
Q33332473Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen

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