Functional analysis of the relationship between Vpx and the restriction factor SAMHD1.

scientific article

Functional analysis of the relationship between Vpx and the restriction factor SAMHD1. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.403816
P932PMC publication ID3510820
P698PubMed publication ID23076149

P50authorJocelyn TurpinQ41881598
Renaud MahieuxQ60975730
Andrea CimarelliQ63707555
P2093author name stringKevin Tartour
Gregory Berger
Stéphanie Cordeil
Xuan-Nhi Nguyen
P2860cites workSAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infectionQ21089603
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutationsQ24310328
The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infectionQ24318267
Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune responseQ24338296
Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx proteinQ24605807
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by VpxQ24605940
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphatesQ24624362
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 proteinQ24635842
Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infectionQ28472652
HIV-1 accessory proteins--ensuring viral survival in a hostile environmentQ29619538
Major nucleolar proteins shuttle between nucleus and cytoplasmQ29620425
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Q30421200
Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restrictionQ33331396
Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytesQ33782594
Basic residues in human immunodeficiency virus type 1 nucleocapsid promote virion assembly via interaction with RNA.Q33800960
APOBEC3A is a specific inhibitor of the early phases of HIV-1 infection in myeloid cells.Q34037651
HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1.Q34256688
Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptaseQ34313399
Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferonQ35089155
The nucleolus directly regulates p53 export and degradationQ35208462
Vpx is critical for SIVmne infection of pigtail macaquesQ35965316
Tight interplay among SAMHD1 protein level, cellular dNTP levels, and HIV-1 proviral DNA synthesis kinetics in human primary monocyte-derived macrophagesQ36052320
Role of SAMHD1 nuclear localization in restriction of HIV-1 and SIVmacQ36136752
The interaction of HIV with dendritic cells: outcomes and pathwaysQ36976708
Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cellsQ36994727
Characterization of the behavior of functional viral genomes during the early steps of human immunodeficiency virus type 1 infection.Q37256671
Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?Q37728096
Characterization of restrictions to human immunodeficiency virus type 1 infection of monocytesQ37730431
The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx.Q39405160
Kinetics of human immunodeficiency virus type 1 reverse transcription in blood mononuclear phagocytes are slowed by limitations of nucleotide precursorsQ40039220
SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cellsQ40185026
With a little help from a friend: increasing HIV transduction of monocyte-derived dendritic cells with virion-like particles of SIV(MAC).Q40307361
Conserved amino acids of the human immunodeficiency virus type 2 Vpx nuclear localization signal are critical for nuclear targeting of the viral preintegration complex in non-dividing cellsQ40344399
Phosphorylation by MAPK regulates simian immunodeficiency virus Vpx protein nuclear import and virus infectivityQ40489476
A novel nuclear export signal and a REF interaction domain both promote mRNA export by the Epstein-Barr virus EB2 protein.Q40693893
Vpx association with mature core structures of HIV-2.Q41211919
A simple, versatile and efficient method to genetically modify human monocyte-derived dendritic cells with HIV-1-derived lentiviral vectorsQ84261542
P433issue49
P407language of work or nameEnglishQ1860
P1104number of pages8
P304page(s)41210-41217
P577publication date2012-10-17
P1433published inJournal of Biological ChemistryQ867727
P1476titleFunctional analysis of the relationship between Vpx and the restriction factor SAMHD1.
P478volume287