Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature

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Role for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..10919846M
P356DOI10.1073/PNAS.1211517109
P932PMC publication ID3511761
P698PubMed publication ID23150555
P5875ResearchGate publication ID233412128

P2093author name stringHemalini Williams
Naomi E Rance
Melinda A Mittelman-Smith
Nathaniel T McMullen
Sally J Krajewski-Hall
P2860cites workThe hop phytoestrogen, 8-prenylnaringenin, reverses the ovariectomy-induced rise in skin temperature in an animal model of menopausal hot flushesQ24673333
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Minireview: kisspeptin/neurokinin B/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretionQ28283342
Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weightQ30419024
An Improved Method for Recording Tail Skin Temperature in the Rat Reveals Changes During the Estrous Cycle and Effects of Ovarian SteroidsQ30429936
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Hypertrophy and Increased Gene Expression of Neurons Containing Neurokinin-B and Substance-P Messenger Ribonucleic Acids in the Hypothalami of Postmenopausal Women*Q33262631
Single cell transcriptomics of hypothalamic warm sensitive neurons that control core body temperature and fever response Signaling asymmetry and an extension of chemical neuroanatomyQ33726456
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TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproductionQ34902985
Hot flushesQ35024871
Ambient temperature and 17β-estradiol modify Fos immunoreactivity in the median preoptic nucleus, a putative regulator of skin vasomotion.Q35046872
Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat.Q35590767
Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproductionQ35607255
Thermoregulatory phenotype of the Trpv1 knockout mouse: thermoeffector dysbalance with hyperkinesis.Q36197937
A thermosensory pathway that controls body temperatureQ36711440
Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedbackQ37076705
Symptoms of menopause: hot flushesQ37234305
The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not.Q37391727
Concepts to utilize in describing thermoregulation and neurophysiological evidence for how the system works.Q37625878
Thermal biology of the laboratory ratQ37948510
Luteinizing hormone releasing factor in pituitary stalk plasma from long-term ovariectomized rats: effects of steroidsQ38356772
Parallel preoptic pathways for thermoregulationQ40379118
Roles of two preoptic cell groups in tonic and febrile control of rat tail sympathetic fibersQ40397347
Rat tail skin temperature monitored noninvasively by radiotelemetry: characterization by examination of vasomotor responses to thermomodulatory agentsQ40569895
The rostral raphe pallidus nucleus mediates pyrogenic transmission from the preoptic area.Q40581445
LH, FSH and skin temperaure during the menopausal hot flashQ41630669
Menopausal Flushes: a Neuroendocrine Link with Pulsatile Luteinizing Hormone SecretionQ41710684
Neurokinin B and dynorphin A in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat.Q42467752
Effects of estrogen on thermoregulatory tail vasomotion and heat-escape behavior in freely moving female ratsQ43569467
Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient ratsQ43604541
Estrogen receptor-beta immunoreactivity in luteinizing hormone-releasing hormone neurons of the rat brainQ43646714
Rat tail skin temperature regulation by estrogen, phytoestrogens and tamoxifenQ43968242
Oestradiol and mirtazapine restore the disturbed tail-temperature of oestrogen-deficient ratsQ44683186
Simultaneous telemetric monitoring of tail-skin and core body temperature in a rat model of thermoregulatory dysfunctionQ46168849
Effects of estrogen on thermoregulatory evaporation in rats exposed to heatQ46224327
Regulation of Kiss1 gene expression in the brain of the female mouse.Q46513180
Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminenceQ46605330
Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouseQ47418352
Hypertrophy and increased kisspeptin gene expression in the hypothalamic infundibular nucleus of postmenopausal women and ovariectomized monkeysQ48174465
The effects of hormone replacement therapy on hypothalamic neuropeptide gene expression in a primate model of menopauseQ48184173
Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent modelsQ48361261
Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: Morphologic evidence of interrelated function within the arcuate nucleusQ48443918
Pharmacokinetic and pharmacodynamic profiles of the novel serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized Sprague-Dawley ratsQ48503316
In situ hybridization analysis of the distribution of neurokinin-3 mRNA in the rat central nervous systemQ48939897
Activation of gonadotropin-releasing hormone neurons by kisspeptin as a neuroendocrine switch for the onset of puberty.Q50745717
The inhibitory effects of neurokinin B on GnRH pulse generator frequency in the female rat.Q51385117
Projections of arcuate nucleus and rostral periventricular kisspeptin neurons in the adult female mouse brain.Q51476822
Inactivating KISS1 mutation and hypogonadotropic hypogonadismQ55671569
Effects of Ovariectomy on the Neuroendocrine Axes Regulating Reproduction and Energy Balance in Young Cynomolgus MacaquesQ62073288
Estrogen replacement in middle-aged women: thermoregulatory responses to exercise in the heatQ67590076
Neurokinin B gene expression is increased in the arcuate nucleus of ovariectomized ratsQ71668975
Selected contribution: ambient temperature for experiments in rats: a new method for determining the zone of thermal neutralityQ74115204
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectestrogenQ277954
dynorphinQ324076
vasodilationQ14859627
P304page(s)19846-19851
P577publication date2012-11-12
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRole for kisspeptin/neurokinin B/dynorphin (KNDy) neurons in cutaneous vasodilatation and the estrogen modulation of body temperature
P478volume109

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