4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry

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4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S11419-015-0287-4
P932PMC publication ID4705136
P698PubMed publication ID26793277
P5875ResearchGate publication ID282538511

P50authorMarilyn HuestisQ60467738
P2093author name stringAriane Wohlfarth
Kayla N Ellefsen
Madeleine J Swortwood
Xingxing Diao
Marta Concheiro
P2860cites workDeath following recreational use of designer drug "bath salts" containing 3,4-Methylenedioxypyrovalerone (MDPV).Q36548946
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Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' productsQ36610017
Suspected impaired driving case involving α-pyrrolidinovalerophenone, methylone and ethyloneQ38248827
Seizures associated with synthetic cathinone exposures in the pediatric populationQ40207751
Three fatal intoxications due to methyloneQ40286882
New recreational drug 1-phenyl-2-(1-pyrrolidinyl)-1-pentanone (alpha-PVP) activates central nervous system via dopaminergic neuronQ42707453
New designer drug of abuse: 3,4-Methylenedioxypyrovalerone (MDPV). Findings from apprehended drivers in FinlandQ42743410
Mephedrone (4-methylmethcathinone)-related deathsQ42744621
The detection of mephedrone (4-methylmethcathinone) in 4 fatalities in ScotlandQ42946688
Acute methylone intoxication in an accidental drowning--a case reportQ43595279
Sudden cardiac death associated with methylone use.Q44011078
Establishment of drug codes for 26 substances. Final ruleQ46271509
Analysis of 4-MEC in biological and non-biological material--three case reportsQ50056262
Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-α-PVP, and phenethylamine derivative 4-methylbuphedrine frQ56689548
In silico and in vitro metabolism studies support identification of designer drugs in human urine by liquid chromatography/quadrupole-time-of-flight mass spectrometryQ61037219
The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humansQ73197234
An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletionQ80859486
Testing for designer stimulants: metabolic profiles of 16 synthetic cathinones excreted free in human urineQ87518537
Schedules of controlled substances: temporary placement of 10 synthetic cathinones into Schedule I. Final orderQ95563786
Recreational use of mephedrone (4-methylmethcathinone, 4-MMC) with associated sympathomimetic toxicityQ24631444
Metabolism of the new designer drug α-pyrrolidinopropiophenone (PPP) and the toxicological detection of PPP and 4′-methyl-α-pyrrolidinopropiophenone (MPPP) studied in rat urine using gas chromatography-mass spectrometryQ28212734
3,4-methylenedioxypyrovalerone (MDPV): chemistry, pharmacology and toxicology of a new designer drug of abuse marketed onlineQ28250709
Pharmacological characterization of designer cathinones in vitroQ28273207
Beta-keto amphetamines: studies on the metabolism of the designer drug mephedrone and toxicological detection of mephedrone, butylone, and methylone in urine using gas chromatography-mass spectrometryQ28277604
Mephedrone: use, subjective effects and health risks.Q30402845
Studies on the metabolism and toxicological detection of the new designer drug 4'-methyl-alpha-pyrrolidinopropiophenone in urine using gas chromatography-mass spectrometryQ31057190
Multiple-drug toxicity caused by the coadministration of 4-methylmethcathinone (mephedrone) and heroinQ34111094
Pharmacology of novel synthetic stimulants structurally related to the "bath salts" constituent 3,4-methylenedioxypyrovalerone (MDPV).Q34122902
Drugs for youth via Internet and the example of mephedroneQ34156700
The pharmacology and toxicology of the synthetic cathinone mephedrone (4-methylmethcathinone).Q34200334
Clinical experience with and analytical confirmation of "bath salts" and "legal highs" (synthetic cathinones) in the United StatesQ34206558
Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomesQ34269371
Psychosis from a bath salt product containing flephedrone and MDPV with serum, urine, and product quantificationQ34270487
In vitro metabolism studies on mephedrone and analysis of forensic casesQ34273882
Analysis of synthetic cathinones commonly found in bath salts in human performance and postmortem toxicology: method development, drug distribution and interpretation of resultsQ34325173
Pentylindole/Pentylindazole Synthetic Cannabinoids and Their 5-Fluoro Analogs Produce Different Primary Metabolites: Metabolite Profiling for AB-PINACA and 5F-AB-PINACAQ34464722
Two Fatal Intoxications with the New Designer Drug Methedrone (4-Methoxymethcathinone)Q34625141
New designer drug alpha-pyrrolidinovalerophenone (PVP): studies on its metabolism and toxicological detection in rat urine using gas chromatographic/mass spectrometric techniquesQ34951585
P921main subjectin silicoQ192572
metabolite identificationQ116678277
P304page(s)61-75
P577publication date2015-08-05
P1433published inForensic ToxicologyQ15724497
P1476title4-Methoxy-α-PVP: in silico prediction, metabolic stability, and metabolite identification by human hepatocyte incubation and high-resolution mass spectrometry
P478volume34

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