| P2093 | author name string | Dan Mercola | |
| | Noriko N Yokoyama | |
| | Xiaolin Zi | |
| | Mark Jordan | |
| | Edward M Uchio | |
| | Andria Denmon | |
| P2860 | cites work | A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice | Q21092211 |
| | Delayed and accelerated aging share common longevity assurance mechanisms | Q21145044 |
| | SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity | Q24294017 |
| | The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism | Q24305332 |
| | Extension of chronological life span in yeast by decreased TOR pathway signaling | Q24539948 |
| | Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys | Q24568041 |
| | Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity | Q24598427 |
| | Extending healthy life span--from yeast to humans | Q24599191 |
| | SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress | Q24599420 |
| | Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases | Q24608197 |
| | Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes | Q24616983 |
| | Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans | Q24618226 |
| | The histone deacetylase SIRT2 stabilizes Myc oncoproteins | Q24622277 |
| | The ancient drug salicylate directly activates AMP-activated protein kinase | Q24630758 |
| | Rapamycin fed late in life extends lifespan in genetically heterogeneous mice | Q24647805 |
| | Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span | Q24649811 |
| | Resveratrol: a review of preclinical studies for human cancer prevention | Q24675163 |
| | Benefits of short-term dietary restriction in mammals | Q26830788 |
| | Rapalogs in cancer prevention: anti-aging or anticancer? | Q26866151 |
| | Diabetes and cancer: a consensus report. | Q27686977 |
| | The hallmarks of aging | Q28131641 |
| | A prospective study of plasma C-peptide and colorectal cancer risk in men | Q28168133 |
| | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan | Q28203572 |
| | Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene | Q28205723 |
| | The sirtuin SIRT6 regulates lifespan in male mice | Q28260687 |
| | TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO | Q28266047 |
| | Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Q28274682 |
| | Substrate-specific activation of sirtuins by resveratrol | Q28305166 |
| | Metformin in obesity, cancer and aging: addressing controversies | Q28480735 |
| | Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 | Q28509079 |
| | Cancer chemoprevention: a rapidly evolving field. | Q37003415 |
| | Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues | Q37024437 |
| | SIRT1 promotes RGC survival and delays loss of function following optic nerve crush | Q37053162 |
| | A twenty-first century cancer epidemic caused by obesity: the involvement of insulin, diabetes, and insulin-like growth factors | Q37105231 |
| | Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients | Q37138421 |
| | Different dietary restriction regimens extend lifespan by both independent and overlapping genetic pathways in C. elegans | Q37187457 |
| | Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial | Q37217429 |
| | mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome | Q37256834 |
| | Prevention of cancer by inhibiting aging | Q37260020 |
| | Effects of salidroside on glioma formation and growth inhibition together with improvement of tumor microenvironment | Q37309461 |
| | Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3. | Q37361926 |
| | Calorie restriction and sirtuins revisited | Q37362543 |
| | AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer | Q37414462 |
| | AMP-activated protein kinase promotes human prostate cancer cell growth and survival | Q37415957 |
| | SIRT3: as simple as it seems? | Q37419458 |
| | Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. | Q37503122 |
| | Metformin inhibits skin tumor promotion in overweight and obese mice | Q37570847 |
| | Study design of ASPirin in Reducing Events in the Elderly (ASPREE): a randomized, controlled trial | Q37574486 |
| | Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance | Q37581235 |
| | Calories and carcinogenesis: lessons learned from 30 years of calorie restriction research | Q37647283 |
| | Concentration-Dependent Effects of Rhodiola Rosea on Long-Term Survival and Stress Resistance of Yeast Saccharomyces Cerevisiae: The Involvement of YAP 1 and MSN2/4 Regulatory Proteins | Q37651688 |
| | Binding to WGR domain by salidroside activates PARP1 and protects hematopoietic stem cells from oxidative stress | Q37667497 |
| | Rotifers as models for the biology of aging | Q37731742 |
| | AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network | Q37970212 |
| | The insulin and insulin-like growth factor receptor family in neoplasia: an update | Q37984217 |
| | Targeting metabolism for cancer treatment and prevention: metformin, an old drug with multi-faceted effects | Q38016107 |
| | Metabolic regulation by SIRT3: implications for tumorigenesis | Q38022918 |
| | A review of oral toxicity associated with mTOR inhibitor therapy in cancer patients. | Q38073361 |
| | mTOR in aging, metabolism, and cancer | Q38073906 |
| | Oral and intravenously administered mTOR inhibitors for metastatic renal cell carcinoma: pharmacokinetic considerations and clinical implications. | Q38078598 |
| | Development of PI3K inhibitors: lessons learned from early clinical trials | Q38080710 |
| | AMPK: a contextual oncogene or tumor suppressor? | Q38104227 |
| | Development of everolimus, a novel oral mTOR inhibitor, across a spectrum of diseases | Q38105361 |
| | A growing role for mTOR in promoting anabolic metabolism | Q38122221 |
| | The global burden of cancer | Q38165401 |
| | Metformin activates an ataxia telangiectasia mutated (ATM)/Chk2-regulated DNA damage-like response | Q84087887 |
| | Diabetes and cancer | Q84262739 |
| | Cancer and diabetes: are we ready for prime time? | Q84408315 |
| | Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus | Q84819258 |
| | Circulating IGF system and treatment outcome in epithelial ovarian cancer | Q86839911 |
| | Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls | Q87415716 |
| | The effects of metformin on the survival of colorectal cancer patients with diabetes mellitus | Q95383722 |
| | SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism | Q28587694 |
| | Comparative genetics of longevity and cancer: insights from long-lived rodents | Q28652609 |
| | Mammalian sirtuins: biological insights and disease relevance | Q29614496 |
| | Ras, PI(3)K and mTOR signalling controls tumour cell growth | Q29614734 |
| | IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice | Q29616382 |
| | Understanding the odd science of aging | Q29617341 |
| | Rapamycin extends murine lifespan but has limited effects on aging | Q30541884 |
| | One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue | Q31059752 |
| | The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis | Q33584802 |
| | Aspirin is associated with reduced cardiovascular and all-cause mortality in type 2 diabetes in a primary prevention setting: the Fremantle Diabetes study | Q33602214 |
| | Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster | Q33665807 |
| | Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans | Q33696446 |
| | Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2 | Q33790225 |
| | Circadian clock: linking epigenetics to aging | Q33803472 |
| | Rapamycin extends maximal lifespan in cancer-prone mice | Q33816255 |
| | The GH/IGF-1 axis in ageing and longevity | Q33817029 |
| | The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer | Q33893799 |
| | The effect of lithocholic acid on proliferation and apoptosis during the early stages of colon carcinogenesis: differential effect on apoptosis in the presence of a colon carcinogen | Q33899722 |
| | OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. | Q33919545 |
| | Rhodiola rosea: a possible plant adaptogen. | Q33951772 |
| | Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity | Q33976655 |
| | Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. | Q33993373 |
| | Plant adaptogens increase lifespan and stress resistance in C. elegans | Q34012117 |
| | Emerging role of sirtuins on tumorigenesis: possible link between aging and cancer | Q34049423 |
| | Plasma insulin-like growth factor-I and prostate cancer risk: a prospective study | Q34065827 |
| | Calorie restriction: decelerating mTOR-driven aging from cells to organisms (including humans). | Q34097445 |
| | Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function. | Q34136335 |
| | Resveratrol and life extension. | Q34160523 |
| | Theanine and glutamate transporter inhibitors enhance the antitumor efficacy of chemotherapeutic agents | Q34279610 |
| | Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies. | Q34322163 |
| | High absorption but very low bioavailability of oral resveratrol in humans | Q34343815 |
| | Metformin improves healthspan and lifespan in mice | Q34360789 |
| | Role of aspirin in cancer prevention | Q34376832 |
| | Over-expressions of AMPK subunits in ovarian carcinomas with significant clinical implications | Q34381790 |
| | Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer | Q34418424 |
| | Inhibition of lung tumor growth by targeting EGFR/VEGFR-Akt/NF-κB pathways with novel theanine derivatives | Q34483660 |
| | Suppression of proliferation and migration in highly-metastatic lung cancer cells as well as tumor growth by a new synthesized compound TBrC and its molecular mechanisms of action | Q34534784 |
| | Wine, alcohol, platelets, and the French paradox for coronary heart disease | Q34538674 |
| | Resveratrol is a peroxidase-mediated inactivator of COX-1 but not COX-2: a mechanistic approach to the design of COX-1 selective agents. | Q34546310 |
| | Frequency and spectrum of cancers in the Peutz-Jeghers syndrome | Q34567595 |
| | Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission | Q34611836 |
| | Diabetes mellitus and risk of breast cancer: a meta-analysis | Q34614029 |
| | Growth hormone abolishes beneficial effects of calorie restriction in long-lived Ames dwarf mice. | Q34614325 |
| | Resveratrol: challenges in translation to the clinic--a critical discussion | Q34673721 |
| | Extension of Drosophila lifespan by Rhodiola rosea through a mechanism independent from dietary restriction | Q34737725 |
| | Resveratrol in mammals: effects on aging biomarkers, age-related diseases, and life span | Q34820212 |
| | Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB | Q34995412 |
| | Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging | Q35080610 |
| | Rhodiola rosea extracts and salidroside decrease the growth of bladder cancer cell lines via inhibition of the mTOR pathway and induction of autophagy | Q35131862 |
| | Caloric restriction reduces growth of mammary tumors and metastases | Q35190787 |
| | The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun | Q35458082 |
| | Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer | Q35511314 |
| | Lower risk of cancer in patients on metformin in comparison with those on sulfonylurea derivatives: results from a large population-based follow-up study | Q35620231 |
| | Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. | Q35629996 |
| | Targeting the PI3K/Akt/mTOR pathway--beyond rapalogs | Q35640098 |
| | Molecular damage in cancer: an argument for mTOR-driven aging | Q35740772 |
| | Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models. | Q35835794 |
| | Increase in circulating levels of IGF-1 and IGF-1/IGFBP-3 molar ratio over a decade is associated with colorectal adenomatous polyps | Q35857006 |
| | Aging, longevity, inflammation, and cancer | Q36138584 |
| | Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging | Q36141285 |
| | L-Theanine extends lifespan of adult Caenorhabditis elegans | Q36164928 |
| | Are sirtuins viable targets for improving healthspan and lifespan? | Q36385747 |
| | The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses | Q36436005 |
| | The effect of resveratrol on lifespan depends on both gender and dietary nutrient composition in Drosophila melanogaster | Q36528271 |
| | Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor | Q36696132 |
| | Frequent homozygous deletion of the LKB1/STK11 gene in non-small cell lung cancer | Q36740152 |
| | Three-gene immunohistochemical panel adds to clinical staging algorithms to predict prognosis for patients with esophageal adenocarcinoma | Q36763844 |
| | Resveratrol directly targets COX-2 to inhibit carcinogenesis. | Q36926520 |
| | What are the roles of calorie restriction and diet quality in promoting healthy longevity? | Q38167571 |
| | Sirtuins and cancer: new insights and cell signaling | Q38168292 |
| | Targeting PI3K/Akt/mTOR Signaling in Cancer | Q38208314 |
| | Prevention and treatment of cancer with aspirin: where do we stand? | Q38229399 |
| | Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome | Q38312576 |
| | Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation. | Q38969133 |
| | Metformin is synthetically lethal with glucose withdrawal in cancer cells. | Q39312255 |
| | Salidroside inhibits migration and invasion of human fibrosarcoma HT1080 cells | Q39462192 |
| | mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. | Q39616865 |
| | Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids | Q40061657 |
| | Antiangiogenic and apoptotic properties of a novel amphiphilic folate-heparin-lithocholate derivative having cellular internality for cancer therapy | Q40167498 |
| | Theanine, a specific glutamate derivative in green tea, reduces the adverse reactions of doxorubicin by changing the glutathione level | Q40531021 |
| | The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans | Q41711470 |
| | Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism. | Q41823360 |
| | A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology | Q41959039 |
| | SIRT3 reverses aging-associated degeneration | Q42029936 |
| | Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells | Q42149700 |
| | Effect of different doses of metformin on serum testosterone and insulin in non-diabetic women with breast cancer: a randomized study. | Q42506632 |
| | Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria | Q42848863 |
| | Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial | Q42920181 |
| | Clinical outcomes after radical prostatectomy in diabetic patients treated with metformin | Q42971655 |
| | Rhodiola algida improves chemotherapy-induced oral mucositis in breast cancer patients | Q43107256 |
| | Diabetes mellitus and risk of prostate cancer: a meta-analysis | Q44236570 |
| | Sirt1 regulates aging and resistance to oxidative stress in the heart | Q44830459 |
| | Metformin therapy in a transgenic mouse model of Huntington's disease. | Q45303200 |
| | Effect of dietary macronutrient composition on AMPK and SIRT1 expression and activity in human skeletal muscle | Q45326878 |
| | Altered expression of SIRT gene family in head and neck squamous cell carcinoma. | Q45416449 |
| | Introduction: sirtuins in aging and diseases | Q45879485 |
| | Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. | Q45919186 |
| | Urothelial overexpression of insulin-like growth factor-1 increases susceptibility to p-cresidine-induced bladder carcinogenesis in transgenic mice. | Q46025424 |
| | Use of microarray biomarkers to identify longevity therapeutics | Q46101205 |
| | SIRT2: tumour suppressor or tumour promoter in operable breast cancer? | Q46191642 |
| | Biomedicine. A putative antiaging drug takes a step from mice to men. | Q46418325 |
| | Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth | Q46603046 |
| | A gain-of-function screen identifies wdb and lkb1 as lifespan-extending genes in Drosophila | Q47071654 |
| | Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway | Q47907595 |
| | Health span extension through green chemoprevention | Q48562314 |
| | Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans | Q48632135 |
| | Insulin-like growth factor I and risk of breast cancer by age and hormone receptor status-A prospective study within the EPIC cohort. | Q53082610 |
| | Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205. | Q53184000 |
| | Reduced longevity in untreated patients with isolated growth hormone deficiency. | Q53920851 |
| | Hepatic gene expression profile of lipid metabolism in rats: Impact of caloric restriction and growth hormone/insulin-like growth factor-1 suppression. | Q53934255 |
| | Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice. | Q54407754 |
| | Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. | Q54606528 |
| | [The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research)] | Q72322817 |
| | Dietary restriction reduces insulin-like growth factor I levels, which modulates apoptosis, cell proliferation, and tumor progression in p53-deficient mice | Q73838225 |
| | L-theanine . Monograph | Q81911428 |
| | Why women live longer. Stress alone does not explain the longevity gap | Q82223641 |
| P433 | issue | 6 | |
| P304 | page(s) | 420-433 | |
| P577 | publication date | 2015-04-14 | |
| P1433 | published in | Current pharmacology reports | Q27726236 |
| P1476 | title | When Anti-Aging Studies Meet Cancer Chemoprevention: Can Anti-Aging Agent Kill Two Birds with One Blow? | |
| P478 | volume | 1 | |