Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-α or TLR-9 agonist and GM-CSF with peptide vaccination

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Differing patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-α or TLR-9 agonist and GM-CSF with peptide vaccination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/CJI.0B013E318272569B
P932PMC publication ID3513773
P698PubMed publication ID23090079

P2093author name stringAhmad A Tarhini
William E Gooding
John M Kirkwood
Lisa H Butterfield
Yongli Shuai
Pawel Kalinski
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Tremelimumab (anti-CTLA4) mediates immune responses mainly by direct activation of T effector cells rather than by affecting T regulatory cellsQ43745656
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Tumor progression can occur despite the induction of very high levels of self/tumor antigen-specific CD8+ T cells in patients with melanomaQ45287769
Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206.Q46106546
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Identification of a New Subset of Myeloid Suppressor Cells in Peripheral Blood of Melanoma Patients With Modulation by a Granulocyte-Macrophage Colony-Stimulation Factor–Based Antitumor VaccineQ60311223
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Increased expression of human monocyte HLA-DR antigens and Fc gamma receptors in response to human interferon in vivoQ70163400
Vitiligo in patients with metastatic melanoma: a good prognostic signQ71105100
Mechanisms of immune suppression in patients with head and neck cancer: influence on the immune infiltrate of the cancerQ71258120
High-dose interferon alfa-2b significantly prolongs relapse-free and overall survival compared with the GM2-KLH/QS-21 vaccine in patients with resected stage IIB-III melanoma: results of intergroup trial E1694/S9512/C509801Q73825066
A unique subset of CD4+CD25highFoxp3+ T cells secreting interleukin-10 and transforming growth factor-beta1 mediates suppression in the tumor microenvironmentQ80726091
Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-signQ84256128
P433issue9
P921main subjectantibodyQ79460
toll-like receptorQ408004
metastatic melanomaQ18975855
P304page(s)702-710
P577publication date2012-11-01
P1433published inJournal of ImmunotherapyQ15763946
P1476titleDiffering patterns of circulating regulatory T cells and myeloid-derived suppressor cells in metastatic melanoma patients receiving anti-CTLA4 antibody and interferon-α or TLR-9 agonist and GM-CSF with peptide vaccination
P478volume35

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