Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6. (scientific article)

A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member of the family of hyaluronate binding proteins, closely related to the adhesion receptor CD44

Q24297519

TSG-6 binds via its CUB_C domain to the cell-binding domain of fibronectin and increases fibronectin matrix assembly

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TSG-6, an arthritis-associated hyaluronan binding protein, forms a stable complex with the serum protein inter-alpha-inhibitor

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Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-alpha-stimulated gene-6) in murine models of experimental arthritis

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Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections

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Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients

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PTX3 in small-vessel vasculitides: an independent indicator of disease activity produced at sites of inflammation

Q34106947

A novel allelic variant of the human TSG-6 gene encoding an amino acid difference in the CUB module. Chromosomal localization, frequency analysis, modeling, and expression

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The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner.

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Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

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Biochemical and functional characterization of the interaction between pentraxin 3 and C1q.

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TSG-6: a multifunctional protein associated with inflammation

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PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization

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Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction

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TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo

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The TSG-6 and I alpha I interaction promotes a transesterification cleaving the protein-glycosaminoglycan-protein (PGP) cross-link.

Q34384870

Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility

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TSG-6: an IL-1/TNF-inducible protein with anti-inflammatory activity

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Interferon-gamma inhibits expression of the long pentraxin PTX3 in human monocytes

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TSG-6: a pluripotent inflammatory mediator?

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Induction of the hyaluronic acid-binding protein, tumor necrosis factor-stimulated gene-6, in cervical smooth muscle cells by tumor necrosis factor-alpha and prostaglandin E(2).

Q35788881

TSG-6 potentiates the antitissue kallikrein activity of inter-alpha-inhibitor through bikunin release.

Q35855257

Differential expression of RANK, RANK-L, and osteoprotegerin by synovial fluid neutrophils from patients with rheumatoid arthritis and by healthy human blood neutrophils

Q35868974

The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps

Q36229261

TSG-6: a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis

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TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation

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The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells

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Characterization of complexes formed between TSG-6 and inter-alpha-inhibitor that act as intermediates in the covalent transfer of heavy chains onto hyaluronan.

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Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells

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Inflammatory cells and bone loss in rheumatoid arthritis

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Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

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Inhibitory effects of TSG-6 Link module on leukocyte-endothelial cell interactions in vitro and in vivo.

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Hyaluronan binding properties of a CD44 chimera containing the link module of TSG-6.

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Cartilage-specific constitutive expression of TSG-6 protein (product of tumor necrosis factor alpha-stimulated gene 6) provides a chondroprotective, but not antiinflammatory, effect in antigen-induced arthritis

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Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice

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Molecular heterogeneity of the SHAP-hyaluronan complex. Isolation and characterization of the complex in synovial fluid from patients with rheumatoid arthritis

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Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

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Decidual stromal cell response to paracrine signals from the trophoblast: amplification of immune and angiogenic modulators

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Hyaluronan cross-linking: a protective mechanism in inflammation?

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The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing.

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Distinct transcriptional programs activated by interleukin-10 with or without lipopolysaccharide in dendritic cells: induction of the B cell-activating chemokine, CXC chemokine ligand 13.

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PTX3 interacts with inter-alpha-trypsin inhibitor: implications for hyaluronan organization and cumulus oophorus expansion

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Knockout of pentraxin 3, a downstream target of growth differentiation factor-9, causes female subfertility

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Defect in SHAP-hyaluronan complex causes severe female infertility. A study by inactivation of the bikunin gene in mice.

Q50720014

Complexity and complementarity of outer membrane protein A recognition by cellular and humoral innate immunity receptors.

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Overexpression, purification, and refolding of link module from human TSG-6 in Escherichia coli: effect of temperature, media, and mutagenesis on lysine misincorporation at arginine AGA codons.

Q54584125

Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction

Q56942653

Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice

Q56942821

Elevated maternal levels of the long pentraxin 3 (PTX3) in preeclampsia and intrauterine growth restriction

Q56942827

Regulation of PTX3, a key component of humoral innate immunity in human dendritic cells: stimulation by IL-10 and inhibition by IFN-

Q56942888

Expression and production of the long pentraxin PTX3 in rheumatoid arthritis (RA)

Q56943278

Gene Expression Profiling of Human Endometrial-Trophoblast Interaction in a Coculture Model

Q57375148

Complement Dependent Amplification of the Innate Response to a Cognate Microbial Ligand by the Long Pentraxin PTX3

Q59510820

Enhanced neutrophil extravasation and rapid progression of proteoglycan-induced arthritis in TSG-6-knockout mice

Q61658616

TSG-6, a glycoprotein associated with arthritis, and its ligand hyaluronan exert opposite effects in a murine model of inflammation

Q71343820

Amelioration of collagen-induced arthritis in DBA/1J mice by recombinant TSG-6, a tumor necrosis factor/interleukin-1-inducible protein

Q73363913

Reduced susceptibility to collagen-induced arthritis in DBA/1J mice expressing the TSG-6 transgene

Q78301199

Microarray analysis of lipopolysaccharide-treated human neutrophils

Q78700518

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

white blood cell

Q42395

P304

page(s)

123-132

P577

publication date

2009-04-23

P1433

published in

Journal of Leukocyte Biology

Q1524048

P1476

title

Coregulation in human leukocytes of the long pentraxin PTX3 and TSG-6.

P478

volume

Reverse relations

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