Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB

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Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/MNFR.201000576
P932PMC publication ID3516994
P698PubMed publication ID21520490
P5875ResearchGate publication ID51077397

P50authorVenkatesh L HegdeQ74712749
P2093author name stringMitzi Nagarkatti
Narendra P Singh
Hongbing Guan
Prakash S Nagarkatti
Udai P Singh
Lorne Hofseth
P2860cites workSirtuins: Sir2-related NAD-dependent protein deacetylasesQ21092883
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseQ24293656
Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptorQ24616079
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegansQ28131824
The Sir2 family of protein deacetylasesQ28266179
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alphaQ28274682
Cancer chemopreventive activity of resveratrol, a natural product derived from grapesQ28300555
Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicityQ28373210
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growthQ33328513
Activation of SIRT1 by resveratrol induces KLF2 expression conferring an endothelial vasoprotective phenotypeQ33573661
Resveratrol (trans-3,5,4'-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulfate sodium-induced colitisQ33714931
Resveratrol, an activator of SIRT1, upregulates sarcoplasmic calcium ATPase and improves cardiac function in diabetic cardiomyopathyQ33727613
Progress in cancer chemoprevention: development of diet-derived chemopreventive agentsQ33866231
Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models.Q34095558
Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapesQ34136974
SIRT1 and p53, effect on cancer, senescence and beyondQ34341091
Molecular targets of dietary agents for prevention and therapy of cancerQ34505253
Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?Q34749734
Calorie restriction, SIRT1 and metabolism: understanding longevityQ36071224
Role of alterations in the apoptotic machinery in sensitivity of cancer cells to treatmentQ36683578
Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptorQ36700407
Deregulation of apoptosis in acute myeloid leukemiaQ36710499
Resveratrol in prevention and treatment of common clinical conditions of agingQ36897454
Sirtuins: critical regulators at the crossroads between cancer and agingQ36908428
SIRT1, is it a tumor promoter or tumor suppressor?Q37073490
Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant miceQ37097951
Trans-resveratrol: a magical elixir of eternal youth?Q37239695
Activation of SIRT1 by resveratrol represses transcription of the gene for the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) by deacetylating hepatic nuclear factor 4alphaQ37447875
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinomaQ38494370
Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventionsQ39330044
Resveratrol confers resistance against taxol via induction of cell cycle arrest in human cancer cell linesQ39697029
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.Q39718199
Inhibition of mammalian S6 kinase by resveratrol suppresses autophagyQ39739155
Resveratrol enhances perforin expression and NK cell cytotoxicity through NKG2D-dependent pathwaysQ39750834
The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.Q39832644
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivationQ40004324
Resveratrol-induced apoptosis in human T-cell acute lymphoblastic leukaemia MOLT-4 cellsQ40080473
SIRT1 is significantly elevated in mouse and human prostate cancer.Q40105577
Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expressionQ40238356
Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.Q40351494
Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators.Q40474534
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilizationQ40708852
Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signaling-dependent apoptosis in human tumor cellsQ41021779
Wine as a biological fluid: history, production, and role in disease preventionQ41591057
Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancerQ41841905
Antitumor and immunomodulatory activity of resveratrol on experimentally implanted tumor of H22 in Balb/c miceQ42204516
SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrolQ42798510
Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic ratsQ43120253
Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells.Q43640339
Protective effects of resveratrol on hydrogen peroxide-induced apoptosis in rat pheochromocytoma (PC12) cellsQ43733589
Resveratrol inhibits the growth and induces the apoptosis of both normal and leukemic hematopoietic cells.Q44084996
Treatment of mice with 2,3,7,8-tetrachlorodibenzo-p-dioxin leads to aryl hydrocarbon receptor-dependent nuclear translocation of NF-kappaB and expression of Fas ligand in thymic stromal cells and consequent apoptosis in T cells.Q44911522
Resveratrol induces FasL-related apoptosis through Cdc42 activation of ASK1/JNK-dependent signaling pathway in human leukemia HL-60 cells.Q44951931
Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.Q53343691
Potential pro-inflammatory action of resveratrol in vascular smooth muscle cells from normal and diabetic ratsQ59385199
P433issue8
P921main subjectNF-κBQ411114
P304page(s)1207-1218
P577publication date2011-04-26
P1433published inMolecular Nutrition and Food ResearchQ15751861
P1476titleResveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB
P478volume55

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cites work (P2860)
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Q37684132The multiple mechanisms of cell death triggered by resveratrol in lymphoma and leukemia

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