Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells

scientific article

Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPRENAL.00692.2011
P932PMC publication ID3517630
P698PubMed publication ID22952279
P5875ResearchGate publication ID230804832

P2093author name stringDarren P Wallace
Cibele S Pinto
Corey White
Emily Nivens
Gail A Reif
P2860cites workCa2+-calmodulin-dependent phosphodiesterase (PDE1): current perspectivesQ28239432
Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cellsQ28505110
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Impaired water reabsorption in mice deficient in the type VI adenylyl cyclase (AC6)Q28590267
Co-assembly of polycystin-1 and -2 produces unique cation-permeable currentsQ29615755
The cytoplasmic C-terminal fragment of polycystin-1 regulates a Ca2+-permeable cation channelQ31484726
Characterization of vasopressin-responsive collecting duct adenylyl cyclases in the mouseQ33783994
Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct.Q33912091
Regulation and role of adenylyl cyclase isoformsQ33939373
Tissue specificity and physiological relevance of various isoforms of adenylyl cyclaseQ34019710
Histopathological analysis of renal cystic epithelia in the Pkd2WS25/- mouse model of ADPKD.Q34212778
Molecular biological approaches to unravel adenylyl cyclase signaling and functionQ34263887
Adenylate cyclase 6 determines cAMP formation and aquaporin-2 phosphorylation and trafficking in inner medullaQ34457128
Regulation and organization of adenylyl cyclases and cAMP.Q34648713
Cyclic AMP-mediated cyst expansionQ34850793
Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous systemQ35073678
Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approachQ35216906
Ouabain activates the Na-K-ATPase signalosome to induce autosomal dominant polycystic kidney disease cell proliferationQ35326185
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cellsQ35372931
Expression and localization of the water channels in human autosomal dominant polycystic kidney diseaseQ73153449
[The effect of hypervolemia on electrolyte level and and level of volume regulating hormones in patients with autosomal dominant polycystic kidney disease]Q73180314
cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathwayQ73664706
The expression of water channels AQP1 and AQP2 in a large series of ADPKD kidneysQ74133107
Chloride and fluid secretion in polycystic kidney diseaseQ74575440
Effective treatment of an orthologous model of autosomal dominant polycystic kidney diseaseQ76390332
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Increased water intake decreases progression of polycystic kidney disease in the PCK ratQ79810674
Cyclic AMP, at the hub of the cystic cycleQ80487963
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Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cellsQ81555343
Vasopressin-2 receptor antagonists in autosomal dominant polycystic kidney disease: from man to mouse and backQ84626176
Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressinQ35543229
Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice.Q35652098
Inhibitors of membranous adenylyl cyclasesQ35740305
Polycystins: from mechanosensation to gene regulationQ35839650
AKAP (A-kinase anchoring protein) domains: beads of structure-function on the necklace of G-protein signallingQ35922931
Compartmentalization of adenylate cyclase and cAMP signallingQ36295428
Vasopressin directly regulates cyst growth in polycystic kidney diseaseQ36667140
Vasopressin antagonists in polycystic kidney diseaseQ36697096
Chloride and fluid secretion by cultured human polycystic kidney cellsQ36828895
Organization and Ca2+ regulation of adenylyl cyclases in cAMP microdomainsQ36872222
Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alphaV-integrin receptorQ36977390
Cyclic nucleotide signaling in polycystic kidney diseaseQ37051278
G-protein-coupled receptor-associated A-kinase anchoring proteins AKAP5 and AKAP12: differential signaling to MAPK and GPCR recyclingQ37052266
Functional expression of the olfactory signaling system in the kidneyQ37100981
Immunolocalization of ion transport proteins in human autosomal dominant polycystic kidney epithelial cellsQ37331486
Adenylyl cyclase--A-kinase anchoring protein complexes: the next dimension in cAMP signalingQ37415827
Capturing adenylyl cyclases as potential drug targetsQ37428727
Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Q37882447
Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular systemQ37950792
Activation and inhibition of adenylyl cyclase isoforms by forskolin analogs.Q40026894
Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotypeQ40533652
Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases.Q40824993
Complexity and diversity of mammalian adenylyl cyclasesQ41048221
Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney diseaseQ41078952
The effect of caffeine on renal epithelial cells from patients with autosomal dominant polycystic kidney diseaseQ42527229
A timely characterization of vasopressin-sensitive adenylyl cyclase isoforms in the mouse inner medullary collecting ductQ42842170
Differential expression of adenylyl cyclases in the rat nephronQ43725710
Human airway smooth muscle expresses 7 isoforms of adenylyl cyclase: a dominant role for isoform V.Q43737965
Increased expression of adenylyl cyclase isoforms in the adrenal gland of diabetic Goto-Kakizaki rat.Q44329653
Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneysQ44445058
Duration of effects on clinical parameters and referred hyperalgesia in rats after abdominal surgery and multiple doses of analgesic.Q46700132
Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat.Q46945053
Regulation of cAMP production in initial and terminal inner medullary collecting ductsQ47906259
Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease.Q51789472
Histogenesis of the renal cysts in adult (autosomal dominant) polycystic kidney disease: a histochemical study.Q52848651
The diagnosis and prognosis of autosomal dominant polycystic kidney diseaseQ68564176
A new method for studying human polycystic kidney disease epithelia in cultureQ68979200
Renal epithelial fluid secretion and cyst growth: the role of cyclic AMPQ69117270
Expansion of extracellular volume in early polycystic kidney diseaseQ69534599
AVP-sensitive cAMP production is dependent on calmodulin in both MTAL and MCTQ69842538
Localization of mRNAs encoding Ca2+-inhibitable adenylyl cyclases along the renal tubule. Functional consequences for regulation of the cAMP contentQ71245747
A role for CFTR in human autosomal dominant polycystic kidney diseaseQ71441585
P433issue10
P921main subjectautosomal dominant polycystic kidneyQ2732398
P304page(s)F1412-24
P577publication date2012-09-05
P1433published inAmerican Journal of Physiology - Renal PhysiologyQ2610177
P1476titleCalmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and Cl- secretion by human autosomal dominant polycystic kidney cells
P478volume303

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cites work (P2860)
Q55403111Activation of Calcium-Sensing Receptor increases intracellular calcium and decreases cAMP and mTOR in PKD1 deficient cells.
Q47638249Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease
Q37524076Adenylyl cyclase 6 deficiency ameliorates polycystic kidney disease
Q39158851International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.
Q28246354Nedd9 restrains renal cystogenesis in Pkd1-/- mice
Q27011660Novel role of ouabain as a cystogenic factor in autosomal dominant polycystic kidney disease
Q27000075Pathophysiology of childhood polycystic kidney diseases: new insights into disease-specific therapy
Q36746073Phosphodiesterase Isoform Regulation of Cell Proliferation and Fluid Secretion in Autosomal Dominant Polycystic Kidney Disease
Q91832389Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2
Q91130409Simple renal cysts are associated with increased arterial stiffness in a Taiwanese population
Q26824644The Role of Calcium and Cyclic AMP in PKD
Q93134163The pathobiology of polycystic kidney disease from a metabolic viewpoint
Q40471569The zebrafish Kupffer's vesicle as a model system for the molecular mechanisms by which the lack of Polycystin-2 leads to stimulation of CFTR.
Q33660700Vasopressin-2 receptor signaling and autosomal dominant polycystic kidney disease: from bench to bedside and back again

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