Primary amines protect against retinal degeneration in mouse models of retinopathies

scientific article

Primary amines protect against retinal degeneration in mouse models of retinopathies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NCHEMBIO.759
P932PMC publication ID3518042
P698PubMed publication ID22198730
P5875ResearchGate publication ID51924440

P50authorKrzysztof PalczewskiQ6440188
Grazyna PalczewskaQ91150768
Akiko MaedaQ104508262
Tadao MaedaQ117279559
Kiichiro OkanoQ117279564
Hideo KohnoQ117279565
Satomi ShioseQ125252067
Marcin GolczakQ88520679
P2093author name stringYu Chen
William Harte
Kaede Ishikawa
P2860cites workIdentification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinolQ22253851
A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophyQ24324625
Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo.Q24537573
Retinopathy in mice induced by disrupted all-trans-retinal clearanceQ24646826
Hydrolytic stability of hydrazones and oximesQ24655081
Noninvasive two-photon imaging reveals retinyl ester storage structures in the eyeQ25255844
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Retinitis pigmentosa caused by a homozygous mutation in the Stargardt disease gene ABCRQ28117716
Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout miceQ28140171
Autosomal recessive retinitis pigmentosa and cone-rod dystrophy caused by splice site mutations in the Stargardt's disease gene ABCRQ28262021
Binding of N-retinylidene-PE to ABCA4 and a model for its transport across membranesQ28284843
Pregabalin may represent a novel class of anxiolytic agents with a broad spectrum of activityQ28345790
Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degenerationQ28505587
Metabolic basis of visual cycle inhibition by retinoid and nonretinoid compounds in the vertebrate retinaQ28587431
Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesisQ28593582
Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epitheliumQ28610021
Role of the C terminus of the photoreceptor ABCA4 transporter in protein folding, function, and retinal degenerative diseases.Q30373731
Three-dimensional architecture of murine rod outer segments determined by cryoelectron tomographyQ30480467
Ophthalmic fundus imaging: today and beyondQ33199285
Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degenerationQ33269883
Phospholipid meets all-trans-retinal: the making of RPE bisretinoidsQ33577803
Positively charged retinoids are potent and selective inhibitors of the trans-cis isomerization in the retinoid (visual) cycleQ33852276
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degenerationQ33905581
Palmitoylation stabilizes unliganded rod opsinQ33929444
Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in miceQ33931582
The biochemical and structural basis for trans-to-cis isomerization of retinoids in the chemistry of visionQ33938844
Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in miceQ34013457
All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light?Q34032765
The ATP-binding cassette transporter ABCA4: structural and functional properties and role in retinal diseaseQ34092691
Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening ConsortiumQ34142148
Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degenerationQ34157723
G protein-coupled receptor rhodopsinQ35017269
Light-induced damage to the retina: role of rhodopsin chromophore revisitedQ36239631
Redundant and unique roles of retinol dehydrogenases in the mouse retinaQ36288722
Diseases caused by defects in the visual cycle: retinoids as potential therapeutic agentsQ36591612
Amino-retinoid compounds in the human retinal pigment epitheliumQ36717086
Reactive carbonyls and oxidative stress: potential for therapeutic interventionQ36849897
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors.Q36887564
Involvement of all-trans-retinal in acute light-induced retinopathy of miceQ37200892
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.Q37415751
Lecithin:retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycleQ40363400
Multienzyme analysis of visual cycleQ41993589
Compositional studies of human RPE lipofuscinQ42880056
ABCR, the ATP-binding cassette transporter responsible for Stargardt macular dystrophy, is an efficient target of all-trans-retinal-mediated photooxidative damage in vitro. Implications for retinal diseaseQ43559716
On the mechanism of isomerization of all-trans-retinol esters to 11-cis-retinol in retinal pigment epithelial cells: 11-fluoro-all-trans-retinol as substrate/inhibitor in the visual cycleQ46515871
Potent and stereospecific anticonvulsant activity of 3-isobutyl GABA relates to in vitro binding at a novel site labeled by tritiated gabapentinQ48369138
The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.Q50511473
Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding proteinQ74620335
Severe autosomal recessive retinitis pigmentosa maps to chromosome 1p13.3-p21.2 between D1S2896 and D1S457 but outside ABCA4Q81273667
P433issue2
P921main subjectretinal degenerationQ3043268
all-trans-retinalQ28529715
P304page(s)170-178
P577publication date2011-12-25
P1433published inNature Chemical BiologyQ904026
P1476titlePrimary amines protect against retinal degeneration in mouse models of retinopathies
P478volume8