New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice

scientific article

New Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1158/1535-7163.MCT-14-0470
P932PMC publication ID4710371
P698PubMed publication ID25646014
P5875ResearchGate publication ID272083963

P50authorHuamin WangQ100431736
P2093author name stringCraig D Logsdon
Thiruvengadam Arumugam
Laura Bover
Vijaya Ramachandran
Defeng Deng
P2860cites workAdrenomedullin is expressed in pancreatic cancer and stimulates cell proliferation and invasion in an autocrine manner via the adrenomedullin receptor, ADMR.Q40158363
Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- miceQ41977500
Modulation of epidermal differentiation by epiligrin and integrin alpha 3 beta 1.Q42486320
Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancerQ42599265
Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancerQ44010069
The newt ortholog of CD59 is implicated in proximodistal identity during amphibian limb regenerationQ44199567
Distinct distribution of laminin and its integrin receptors in the pancreasQ44251852
The three-fingered protein domain of the human genomeQ45181692
Cloning of the gene gob-4, which is expressed in intestinal goblet cells in miceQ47976756
High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines.Q53633944
Global gene expression profiling of circulating tumor cells.Q54658711
Positional identity of adult stem cells in salamander limb regenerationQ59595267
Upregulation of C4.4A expression during progression of melanomaQ73443709
The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skinQ78021811
Tumour cell expression of C4.4A, a structural homologue of the urokinase receptor, correlates with poor prognosis in non-small cell lung cancerQ80811993
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycanQ24294965
AGR2 gene function requires a unique endoplasmic reticulum localization motifQ24300169
The protein disulfide isomerase AGR2 is essential for production of intestinal mucusQ24314611
Gapped BLAST and PSI-BLAST: a new generation of protein database search programsQ24545170
The metastasis-associated anterior gradient 2 protein is correlated with poor survival of breast cancer patientsQ24644189
Significance of the metastasis-inducing protein AGR2 for outcome in hormonally treated breast cancer patientsQ24651922
C4.4A as a candidate marker in the diagnosis of colorectal cancerQ24652981
Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein familyQ28254595
Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migrationQ28570491
Cloning and functional characterization of a new phosphatidyl-inositol anchored molecule of a metastasizing rat pancreatic tumorQ28575062
AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and DQ30532006
Cloning of the human homologue of the metastasis-associated rat C4.4A.Q30652851
Human homologue of cement gland protein, a novel metastasis inducer associated with breast carcinomasQ31167775
hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell linesQ31990261
AGR2, an androgen-inducible secretory protein overexpressed in prostate cancerQ34411990
Anterior specification of embryonic ectoderm: the role of the Xenopus cement gland-specific gene XAG-2.Q34463160
The GPI-anchor and protein sortingQ34507752
The adenocarcinoma-associated antigen, AGR2, promotes tumor growth, cell migration, and cellular transformationQ34736863
Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survivalQ34842379
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancerQ35230326
Role of pro-oncogenic protein disulfide isomerase (PDI) family member anterior gradient 2 (AGR2) in the control of endoplasmic reticulum homeostasis.Q35639952
AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasiaQ36449039
The urokinase receptor and its structural homologue C4.4A in human cancer: expression, prognosis and pharmacological inhibitionQ37294301
Regulation of cell signalling by uPAR.Q37660895
Anterior gradient 2: a novel player in tumor cell biologyQ37849416
Membrane-bound and exosomal metastasis-associated C4.4A promotes migration by associating with the α(6)β(4) integrin and MT1-MMP.Q39376527
Suppression of urokinase plasminogen activator receptor inhibits proliferation and migration of pancreatic adenocarcinoma cells via regulation of ERK/p38 signaling.Q39852991
P433issue4
P304page(s)941-951
P577publication date2015-02-02
P1433published inMolecular Cancer TherapeuticsQ2363144
P1476titleNew Blocking Antibodies against Novel AGR2-C4.4A Pathway Reduce Growth and Metastasis of Pancreatic Tumors and Increase Survival in Mice
P478volume14

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cites work (P2860)
Q38714801AGR2 associates with HER2 expression predicting poor outcome in subset of estrogen receptor negative breast cancer patients.
Q40143097AGR2 oncoprotein inhibits p38 MAPK and p53 activation through a DUSP10-mediated regulatory pathway
Q90706001AGR2 silencing contributes to metformin-dependent sensitization of colorectal cancer cells to chemotherapy
Q91866534AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting
Q35799421Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients
Q26765222C4.4A as a biomarker of head and neck squamous cell carcinoma and correlated with epithelial mesenchymal transition
Q36893729C4.4A gene ablation is compatible with normal epidermal development and causes modest overt phenotypes
Q38697147Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis
Q90092778Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain
Q49542602De novo synthesis of C4.4A in hepatocellular carcinoma promotes migration and invasion of tumor cells
Q90705714Extracellular AGR3 regulates breast cancer cells migration via Src signaling
Q58573397Genomic Network-Based Analysis Reveals Pancreatic Adenocarcinoma Up-Regulating Factor-Related Prognostic Markers in Cervical Carcinoma
Q93080668Leveraging the Role of the Metastatic Associated Protein Anterior Gradient Homologue 2 in Unfolded Protein Degradation: A Novel Therapeutic Biomarker for Cancer
Q90695386Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis
Q35995869Mechanism of Action of Secreted Newt Anterior Gradient Protein
Q50086998Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling
Q37083246Secretion of protein disulphide isomerase AGR2 confers tumorigenic properties
Q36621607The metastasis-inducing protein AGR2 is O-glycosylated upon secretion from mammary epithelial cells
Q45325474The prognostic value of AGR2 expression in solid tumours: a systematic review and meta-analysis
Q50020631The sequence-specific peptide-binding activity of the protein sulfide isomerase AGR2 directs its' stable binding to the oncogenic receptor EpCAM.

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