Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts

scientific article

Molecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/MCP.M112.019984
P932PMC publication ID3518138
P698PubMed publication ID22964225
P5875ResearchGate publication ID230828861

P2093author name stringJann N Sarkaria
Forest M White
Mark A Schroeder
Amanda M Del Rosario
Hannah Johnson
Bryan D Bryson
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Epidermal growth factor receptor signaling intensity determines intracellular protein interactions, ubiquitination, and internalizationQ30164745
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Identification of differentially expressed proteins in human glioblastoma cell lines and tumorsQ31136179
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Analysis of phosphotyrosine signaling in glioblastoma identifies STAT5 as a novel downstream target of ΔEGFR.Q34629812
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastomaQ34655394
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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicityQ35660849
Multiple reaction monitoring for robust quantitative proteomic analysis of cellular signaling networksQ35749545
Phosphotyrosine signaling analysis of site-specific mutations on EGFRvIII identifies determinants governing glioblastoma cell growthQ35793511
EGFRvIII undergoes activation-dependent downregulation mediated by the Cbl proteinsQ36508737
Eps15 mediates vesicle trafficking from the trans-Golgi network via an interaction with the clathrin adaptor AP-1.Q36796883
The protein tyrosine phosphatase SHP-2 is required for EGFRvIII oncogenic transformation in human glioblastoma cells.Q37300370
The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signalingQ38349130
The major vault protein mediates resistance to epidermal growth factor receptor inhibition in human hepatoma cellsQ39409582
SIRPalpha1 receptors interfere with the EGFRvIII signalosome to inhibit glioblastoma cell transformation and migration.Q39703419
Carbonic anhydrase III promotes transformation and invasion capability in hepatoma cells through FAK signaling pathwayQ39987247
EGFRvIII escapes down-regulation due to impaired internalization and sorting to lysosomesQ40156909
Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.Q40232913
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathwayQ40410769
Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiformeQ40512036
Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFRQ40619097
Transfection of S100A4 produces metastatic variants of an orthotopic model of bladder cancerQ40751670
Identification of TrkB autophosphorylation sites and evidence that phospholipase C-gamma 1 is a substrate of the TrkB receptorQ41486682
Specific tyrosine phosphorylations mediate signal-dependent stimulation of SHIP2 inositol phosphatase activity, while the SH2 domain confers an inhibitory effect to maintain the basal activityQ42455252
YB-1 facilitates basal and 5-fluorouracil-inducible expression of the human major vault protein (MVP) geneQ42475185
The role of S100 genes in breast cancer progressionQ42481244
Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptorQ42799161
Expression of oncogenic epidermal growth factor receptor family kinases induces paclitaxel resistance and alters beta-tubulin isotype expressionQ42803600
Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene.Q42812982
Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII.Q43200792
Requirement of autophosphorylated tyrosine 992 of EGF receptor and its docking protein phospholipase C gamma 1 for membrane ruffle formationQ44314949
Growth suppression of intracranial xenografted glioblastomas overexpressing mutant epidermal growth factor receptors by systemic administration of monoclonal antibody (mAb) 806, a novel monoclonal antibody directed to the receptor.Q45943467
Intratumoral patterns of genomic imbalance in glioblastomas.Q48230300
The Paragon Algorithm, a next generation search engine that uses sequence temperature values and feature probabilities to identify peptides from tandem mass spectra.Q50993792
Oligodendrogliomas result from the expression of an activated mutant epidermal growth factor receptor in a RAS transgenic mouse astrocytoma model.Q55472981
Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomasQ55480632
P433issue12
P921main subjectglioblastomaQ282142
xenograftQ64148587
tumour xenograftQ112042499
P304page(s)1724-1740
P577publication date2012-09-10
P1433published inMolecular & Cellular ProteomicsQ6895932
P1476titleMolecular characterization of EGFR and EGFRvIII signaling networks in human glioblastoma tumor xenografts
P478volume11

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