| scholarly article | Q13442814 |
| P2093 | author name string | Kyoungho Suk | |
| Sangmin Jeon | |||
| Mithilesh Kumar Jha | |||
| P2860 | cites work | Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase | Q24291531 |
| Diversity of the pyruvate dehydrogenase kinase gene family in humans | Q24304379 | ||
| Pyruvate dehydrogenase activation and kinase expression in human skeletal muscle during fasting | Q24308031 | ||
| Pyruvate dehydrogenase kinase-4 structures reveal a metastable open conformation fostering robust core-free basal activity | Q24317423 | ||
| Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells | Q24320179 | ||
| Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex | Q24320270 | ||
| Cloning and characterization of PDK4 on 7q21.3 encoding a fourth pyruvate dehydrogenase kinase isoenzyme in human | Q24321423 | ||
| Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex | Q24530636 | ||
| The in vivo neuron-to-astrocyte lactate shuttle in human brain: evidence from modeling of measured lactate levels during visual stimulation | Q24648293 | ||
| Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer | Q24652941 | ||
| Metabolic and hemodynamic events after changes in neuronal activity: current hypotheses, theoretical predictions and in vivo NMR experimental findings | Q24655314 | ||
| Supply and demand in cerebral energy metabolism: the role of nutrient transporters | Q24671074 | ||
| Structure of pyruvate dehydrogenase kinase. Novel folding pattern for a serine protein kinase | Q24671402 | ||
| Lactate metabolism: a new paradigm for the third millennium | Q24677962 | ||
| Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1 | Q24681460 | ||
| Junctions between intimately apposed cell membranes in the vertebrate brain | Q24682725 | ||
| Structure of rat BCKD kinase: Nucleotide-induced domain communication in a mitochondrial protein kinase | Q27634871 | ||
| Expression, purification, and characterization of the dihydrolipoamide dehydrogenase-binding protein of the pyruvate dehydrogenase complex from Saccharomyces cerevisiae | Q27930889 | ||
| Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation | Q28116674 | ||
| Tetrameric assembly and conservation in the ATP-binding domain of rat branched-chain alpha-ketoacid dehydrogenase kinase | Q28141279 | ||
| Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs | Q28188766 | ||
| Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study | Q28235582 | ||
| Structure-function relationships in dihydrolipoamide acyltransferases | Q28247047 | ||
| Mitochondrial alpha-ketoacid dehydrogenase kinases: a new family of protein kinases | Q28252413 | ||
| Glycolysis inhibition for anticancer treatment | Q28256222 | ||
| Metabolic modulation of glioblastoma with dichloroacetate | Q28282255 | ||
| A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth | Q28283339 | ||
| HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia | Q28300406 | ||
| Fuel-sensing mechanisms integrating lipid and carbohydrate utilization | Q43610154 | ||
| Control of pyruvate dehydrogenase kinase gene expression | Q43625199 | ||
| Oxidative damage is the earliest event in Alzheimer disease | Q43696731 | ||
| Selective modification of pyruvate dehydrogenase kinase isoform expression in rat pancreatic islets elicited by starvation and activation of peroxisome proliferator-activated receptor-alpha: implications for glucose-stimulated insulin secretion | Q43808948 | ||
| Regulation of pyruvate dehydrogenase kinase expression by peroxisome proliferator-activated receptor-alpha ligands, glucocorticoids, and insulin | Q43867510 | ||
| Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice | Q43917396 | ||
| Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis | Q43954468 | ||
| Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus | Q44305130 | ||
| Dynamic changes in local cerebral glucose utilization following cerebral concussion in rats: evidence of a hyper- and subsequent hypometabolic state | Q44465748 | ||
| Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury | Q44645680 | ||
| Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease | Q44722605 | ||
| Effects of aerobic training on pyruvate dehydrogenase and pyruvate dehydrogenase kinase in human skeletal muscle | Q44799807 | ||
| Increased cerebral uptake and oxidation of exogenous betaHB improves ATP following traumatic brain injury in adult rats | Q44980202 | ||
| Reduction of brain lipid peroxidation by CSF drainage in Alzheimer's disease patients. | Q45042831 | ||
| Mitochondrial alpha-ketoglutarate dehydrogenase complex generates reactive oxygen species. | Q45050765 | ||
| Over-estimation of glucose-6-phosphatase activity in brain in vivo. Apparent difference in rates of [2-3H]glucose and [U-14C]glucose utilization is due to contamination of precursor pool with 14C-labeled products and incomplete recovery of 14C-label | Q45109328 | ||
| Comparative homology modeling of pyruvate dehydrogenase kinase isozymes from Xenopus tropicalis reveals structural basis for their subfunctionalization | Q45798292 | ||
| Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: a mechanism of dysregulated glucose metabolism. | Q46018156 | ||
| Impaired cerebral mitochondrial function after traumatic brain injury in humans | Q46127691 | ||
| Nonischemic energy metabolic crisis in acute brain injury | Q46350521 | ||
| Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice | Q46737335 | ||
| Mitochondrial Abeta: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease | Q47714762 | ||
| A possible contribution by glial cells to neuronal energy production: enzyme-histochemical studies in the developing rat cerebellum | Q48091043 | ||
| Lactate, not pyruvate, is neuronal aerobic glycolysis end product: an in vitro electrophysiological study | Q48140865 | ||
| Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury | Q48159946 | ||
| Energy on demand | Q48283930 | ||
| Mitochondrial dysfunction after experimental and human brain injury and its possible reversal with a selective N-type calcium channel antagonist (SNX-111). | Q48695643 | ||
| Pyruvate carboxylase activity in primary cultures of astrocytes and neurons | Q48719469 | ||
| Ion homeostasis in brain cells: differences in intracellular ion responses to energy limitation between cultured neurons and glial cells | Q48720755 | ||
| Controlled cortical impact injury and craniotomy result in divergent alterations of pyruvate metabolizing enzymes in rat brain | Q48758815 | ||
| Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury | Q48805479 | ||
| The astrocyte--neuron lactate shuttle: a debated but still valuable hypothesis for brain imaging | Q48921655 | ||
| Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. | Q51192756 | ||
| The abundance of mRNAs for pyruvate dehydrogenase kinase isoenzymes in brain regions of young and aged rats. | Q52140076 | ||
| Abundant expression of GLUT1 and GLUT3 in rat embryo during the early organogenesis period. | Q52208965 | ||
| Stoichiometry, organisation and catalytic function of protein X of the pyruvate dehydrogenase complex from bovine heart | Q71047860 | ||
| The hormonal regulation of pyruvate dehydrogenase complex | Q71682906 | ||
| Glycogen in astrocytes: possible function as lactate supply for neighboring cells | Q72558138 | ||
| Starvation increases the amount of pyruvate dehydrogenase kinase in several mammalian tissues | Q73043566 | ||
| Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures | Q73128987 | ||
| Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia | Q77366399 | ||
| The interplay between MYC and HIF in the Warburg effect | Q82039379 | ||
| Human skeletal muscle pyruvate dehydrogenase kinase activity increases after a low-carbohydrate diet | Q93914688 | ||
| HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption | Q28300415 | ||
| PDH activation during in vitro muscle contractions in PDH kinase 2 knockout mice: effect of PDH kinase 1 compensation | Q28307470 | ||
| Evidence that pyruvate dehydrogenase kinase belongs to the ATPase/kinase superfamily | Q28510166 | ||
| Primary structure of pyruvate dehydrogenase kinase establishes a new family of eukaryotic protein kinases | Q28575548 | ||
| Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney | Q28576322 | ||
| Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia | Q29397661 | ||
| Alzheimer's disease is a synaptic failure | Q29547670 | ||
| Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization | Q29620724 | ||
| Astrocytes are poised for lactate trafficking and release from activated brain and for supply of glucose to neurons | Q30479376 | ||
| Proteomic analysis of mitochondria reveals a metabolic switch from fatty acid oxidation to glycolysis in the failing heart | Q30915732 | ||
| Astrocyte-neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions--in silico study supported by in vitro expression data | Q31034673 | ||
| A quantitative overview of glucose dynamics in the gliovascular unit | Q31119991 | ||
| Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes? | Q31119994 | ||
| Towards a genome-scale kinetic model of cellular metabolism | Q33527111 | ||
| Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. | Q33545914 | ||
| Response to 'comment on recent modeling studies of astrocyte-neuron metabolic interactions': much ado about nothing. | Q33852904 | ||
| Neuron-glia metabolic coupling and plasticity | Q33996201 | ||
| Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. | Q34043021 | ||
| The mitochondrial spiral. An adequate cause of dementia in the Alzheimer's syndrome. | Q34148933 | ||
| Brain lactate kinetics: Modeling evidence for neuronal lactate uptake upon activation | Q34160702 | ||
| Glucose transporter 1 and monocarboxylate transporters 1, 2, and 4 localization within the glial cells of shark blood-brain-barriers. | Q34184563 | ||
| Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation | Q34279293 | ||
| Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models | Q34284137 | ||
| Molecular cloning of the p45 subunit of pyruvate dehydrogenase kinase | Q34325800 | ||
| Do active cerebral neurons really use lactate rather than glucose? | Q34384249 | ||
| Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms | Q34408068 | ||
| Astrocyte-mediated control of cerebral blood flow | Q34481040 | ||
| Oxidative and nonoxidative metabolism of excited neurons and astrocytes | Q34504180 | ||
| Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction. | Q34562025 | ||
| Regulation of the pyruvate dehydrogenase complex | Q34565754 | ||
| Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases | Q34572847 | ||
| Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer | Q34575904 | ||
| Metabolic targeting as an anticancer strategy: dawn of a new era? | Q34617961 | ||
| Activity-dependent regulation of energy metabolism by astrocytes: an update | Q34656867 | ||
| Regulation of the activity of the pyruvate dehydrogenase complex | Q34747160 | ||
| A mitocentric view of Alzheimer's disease suggests multi-faceted treatments | Q34902708 | ||
| Energy metabolism in the brain | Q34991023 | ||
| Genetic pathways to primary and secondary glioblastoma | Q35757144 | ||
| Nutrition during brain activation: does cell-to-cell lactate shuttling contribute significantly to sweet and sour food for thought? | Q35774454 | ||
| Protection against ischemic brain injury by inhibition of mitochondrial oxidative stress | Q35891881 | ||
| Neurobarrier coupling in the brain: a partner of neurovascular and neurometabolic coupling? | Q36022927 | ||
| Mitochondria take center stage in aging and neurodegeneration | Q36264218 | ||
| Neuronal-glial glucose oxidation and glutamatergic-GABAergic function. | Q36366441 | ||
| Hippocampal hypometabolism predicts cognitive decline from normal aging | Q36725261 | ||
| Compartmentalization of brain energy metabolism between glia and neurons: insights from mathematical modeling | Q36894705 | ||
| Activation of c-Jun-N-terminal kinase and decline of mitochondrial pyruvate dehydrogenase activity during brain aging | Q37167897 | ||
| Declining brain glucose metabolism in normal individuals with a maternal history of Alzheimer disease | Q37180524 | ||
| Astrocytes as the glucose shunt for glutamatergic neurons at high activity: an in silico study | Q37190449 | ||
| Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease | Q37321251 | ||
| FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease | Q37415324 | ||
| Molecular biology and biochemistry of pyruvate dehydrogenase complexes. | Q37978313 | ||
| The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases | Q37982890 | ||
| A new level of architectural complexity in the human pyruvate dehydrogenase complex | Q38274657 | ||
| The pharmacology of dichloroacetate | Q38300732 | ||
| Glutamine Synthetase: Glial Localization in Brain | Q39138188 | ||
| Fuel selection in animals | Q39748853 | ||
| Regulation of pyruvate metabolism in mammalian tissues | Q39843260 | ||
| Mitochondrial dysfunction early after traumatic brain injury in immature rats | Q40227736 | ||
| Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression | Q40301497 | ||
| Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. | Q40362310 | ||
| Structural correlates of cognition in dementia: quantification and assessment of synapse change. | Q41443879 | ||
| Function of phosphorylation sites on pyruvate dehydrogenase | Q41667973 | ||
| Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease | Q41945324 | ||
| Evaluation of the role of peroxisome-proliferator-activated receptor alpha in the regulation of cardiac pyruvate dehydrogenase kinase 4 protein expression in response to starvation, high-fat feeding and hyperthyroidism | Q42048511 | ||
| Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart | Q42159479 | ||
| Molecular mechanisms underlying the long-term impact of dietary fat to increase cardiac pyruvate dehydrogenase kinase: regulation by insulin, cyclic AMP and pyruvate | Q42441840 | ||
| Evidence for an important role of CIDEA in human cancer cachexia | Q42806317 | ||
| Role of protein synthesis and of fatty acid metabolism in the longer-term regulation of pyruvate dehydrogenase kinase | Q42835053 | ||
| PDK1 plays a critical role in regulating cardiac function in mice and human | Q42842800 | ||
| Hormonal regulation of glycolytic enzyme gene and pyruvate dehydrogenase kinase/phosphatase gene transcription | Q43286186 | ||
| P433 | issue | 4 | |
| P304 | page(s) | 393-403 | |
| P577 | publication date | 2012-12-01 | |
| P1433 | published in | Current Neuropharmacology | Q20181354 |
| P1476 | title | Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders | |
| P478 | volume | 10 |
| Q34012029 | Alpha-lipoic acid as a pleiotropic compound with potential therapeutic use in diabetes and other chronic diseases |
| Q36109558 | BACE1 activity impairs neuronal glucose oxidation: rescue by beta-hydroxybutyrate and lipoic acid. |
| Q41484322 | Compulsive methamphetamine taking in the presence of punishment is associated with increased oxytocin expression in the nucleus accumbens of rats |
| Q37061310 | Differentiation-Dependent Energy Production and Metabolite Utilization: A Comparative Study on Neural Stem Cells, Neurons, and Astrocytes |
| Q41476817 | Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model |
| Q92127373 | Loss-of-Function Mutation in Thiamine Transporter 1 in a Family With Autosomal Dominant Diabetes |
| Q64087728 | Melatonin Therapy Modulates Cerebral Metabolism and Enhances Remyelination by Increasing PDK4 in a Mouse Model of Multiple Sclerosis |
| Q48072091 | Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis. |
| Q37284060 | Purinergic signaling and energy homeostasis in psychiatric disorders |
| Q36674750 | Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy |
| Q91955533 | Pyruvate dehydrogenase complex in cerebral ischemia-reperfusion injury |
| Q33635374 | Pyruvate dehydrogenase kinase as a potential therapeutic target for malignant gliomas |
| Q58730034 | Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism |
| Q65002045 | The Effects of Sodium Dichloroacetate on Mitochondrial Dysfunction and Neuronal Death Following Hypoglycemia-Induced Injury. |
| Q37586141 | The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility |
| Q47397920 | Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein |
Search more.