Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats

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Vitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1139/APNM-2014-0302
P932PMC publication ID4713234
P698PubMed publication ID25761734

P50authorJohn ThyfaultQ37837332
P2093author name stringMatthew J Picklo
P2860cites workReduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or MetforminQ22250892
Antioxidants prevent health-promoting effects of physical exercise in humansQ24646248
Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokinesQ27001148
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Nicotinamide nucleotide transhydrogenase (Nnt) links the substrate requirement in brain mitochondria for hydrogen peroxide removal to the thioredoxin/peroxiredoxin (Trx/Prx) systemQ34075997
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Muscle-derived ROS and thiol regulation in muscle fatigueQ34714163
Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance.Q34733232
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Excess Lipid Availability Increases Mitochondrial Fatty Acid Oxidative Capacity in MuscleQ54986901
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Exercise and detraining: effect on food intake, adiposity and lipogenesis in Osborne-Mendel rats made obese by a high fat dietQ71262198
Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletionQ73779040
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Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.Q36144737
Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant miceQ36330856
High-fat diets cause insulin resistance despite an increase in muscle mitochondriaQ36693972
Multivitamin-multimineral supplements: who uses them?Q36701918
S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese ratsQ36724505
Cessation of daily wheel running differentially alters fat oxidation capacity in liver, muscle, and adipose tissueQ37086221
Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and NntQ37097498
Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2.Q37341488
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Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet.Q38326204
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistanceQ40028148
Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stressQ40218034
Metabolic clearance of the antioxidant ascorbic acid in surgical patientsQ40399109
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Increased levels of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (PGC-1alpha) improve lipid utilisation, insulin signalling and glucose transport in skeletal muscle of lean and insulin-resistant obese Zucker ratsQ43057678
Antioxidant supplementation does not alter endurance training adaptationQ43216585
The deletion variant of nicotinamide nucleotide transhydrogenase (Nnt) does not affect insulin secretion or glucose toleranceQ43244153
Nicotinamide nucleotide transhydrogenase mRNA expression is related to human obesityQ43428621
EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humansQ44355331
Time course of high-fat diet-induced reductions in adipose tissue mitochondrial proteins: potential mechanisms and the relationship to glucose intoleranceQ46379414
Antioxidants preserve redox balance and inhibit c-Jun-N-terminal kinase pathway while improving insulin signaling in fat-fed rats: evidence for the role of oxidative stress on IRS-1 serine phosphorylation and insulin resistanceQ46628645
Mitochondrial capacity in skeletal muscle is not stimulated by weight loss despite increases in insulin action and decreases in intramyocellular lipid contentQ46770144
Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes.Q46961703
Effects of physical activity and weight loss on skeletal muscle mitochondria and relationship with glucose control in type 2 diabetes.Q47286039
Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesityQ47298918
Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesityQ47398932
Changes in visceral adipose tissue mitochondrial content with type 2 diabetes and daily voluntary wheel running in OLETF rats.Q53391635
A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.Q53853490
Tissue-specific control of mitochondrial respiration in obesity-related insulin resistance and diabetes.Q54328647
Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial.Q54379916
P433issue4
P921main subjectobesityQ12174
vitamin CQ199678
P304page(s)343-352
P577publication date2014-12-09
P1433published inApplied Physiology, Nutrition, and MetabolismQ4781559
P1476titleVitamin E and vitamin C do not reduce insulin sensitivity but inhibit mitochondrial protein expression in exercising obese rats
P478volume40

Reverse relations

cites work (P2860)
Q46976040Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats
Q41437011Chronic Eccentric Exercise and Antioxidant Supplementation: Effects on Lipid Profile and Insulin Sensitivity
Q28389360Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?
Q89958204Effect of Stem Cells, Ascorbic Acid and SERCA1a Gene Transfected Stem Cells in Experimentally Induced Type I Diabetic Myopathy
Q90257618Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet
Q33639120Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
Q37693728Exercise, oxidants, and antioxidants change the shape of the bell-shaped hormesis curve
Q55093247Lipidomic Impacts of an Obesogenic Diet Upon Lewis Lung Carcinoma in Mice.
Q64259080Next-Generation Sequencing Identifies Polyunsaturated Fatty Acid Responsive Genes in the Juvenile Rat Cerebellum
Q48148044Prior Endurance Training Enhances Beta-Adrenergic Signaling in Epidydimal Adipose from Mice Fed a High-Fat Diet
Q39833484Prior exercise training blunts short-term high-fat diet-induced weight gain
Q46639762Supplementation with vitamin A enhances oxidative stress in the lungs of rats submitted to aerobic exercise.
Q33852069Vitamin E Modifies High-Fat Diet-Induced Increase of DNA Strand Breaks, and Changes in Expression and DNA Methylation of Dnmt1 and MLH1 in C57BL/6J Male Mice.

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