Impact of obesity on male fertility, sperm function and molecular composition

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Impact of obesity on male fertility, sperm function and molecular composition is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.4161/SPMG.21362
P932PMC publication ID3521747
P698PubMed publication ID23248766
P5875ResearchGate publication ID233942419

P2093author name stringTod Fullston
Michelle Lane
Nicole O Palmer
Hassan W Bakos
P2860cites workDoes weight loss improve semen quality and reproductive hormones? Results from a cohort of severely obese menQ21245035
Regulation of X-chromosome inactivation in development in mice and humansQ24548607
Functional relationship between obesity and male reproduction: from humans to animal modelsQ28236846
The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysisQ28263607
Contemporary concepts in the evaluation and management of male infertilityQ28303523
Oxidative DNA damage impairs global sperm DNA methylation in infertile menQ28392407
Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalanceQ28513538
Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo lossQ28566573
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertilityQ28586787
A survey of small RNAs in human spermQ28742953
Lifestyle impact and the biology of the human scrotumQ28757807
Role of leptin in the neuroendocrine response to fastingQ29618866
Human protamines and the developing spermatid: their structure, function, expression and relationship with male infertility.Q30336699
Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genesQ33347134
The Parkes Lecture. Heat and the testisQ33539688
Diet-induced obesity in male mice is associated with reduced fertility and potentiation of acrylamide-induced reproductive toxicityQ33573301
The epidemiology of obesityQ33708276
Body mass index in relation to semen quality, sperm DNA integrity, and serum reproductive hormone levels among men attending an infertility clinicQ33829506
Epigenetic programming in the preimplantation rat embryo is disrupted by chronic paternal cyclophosphamide exposureQ33833518
Mild Hypogonadotropic hypogonadism in obese men.Q48906328
Male obesity and age in relationship to semen parameters and sperm chromatin integrityQ50278780
Impact of body mass index on seminal oxidative stressQ50280337
Effect of heat stress on the fertility of male mice in vivo and in vitro.Q50645722
Mature human spermatozoa do not transcribe novel RNA.Q50659599
Reproductive biology: delivering spermatozoan RNA to the oocyte.Q50675073
Methylation status of imprinted genes and repetitive elements in sperm DNA from infertile males.Q51508916
Paternal diet-induced obesity impairs embryo development and implantation in the mouseQ51534386
Impact of body mass index values on sperm quantity and quality.Q51828783
Aberrant DNA methylation at imprinted genes in testicular sperm retrieved from men with obstructive azoospermia and undergoing vasectomy reversal.Q51886984
Adverse effects of 5-aza-2'-deoxycytidine on spermatogenesis include reduced sperm function and selective inhibition of de novo DNA methylation.Q52579930
Association between obesity and alteration of sperm DNA integrity and mitochondrial activity.Q53188211
The effect of male body mass index on sperm parameters.Q53349650
Male obesity and alteration in sperm parameters.Q53506969
A single, mild, transient scrotal heat stress causes DNA damage, subfertility and impairs formation of blastocysts in mice.Q55049620
Die Rolle des Gehirns in der Regulation des StoffwechselsQ56591805
Men's body mass index and infertilityQ57420033
DNA methylation in metabolic disordersQ58449821
DNA methylation imprinting marks and DNA methyltransferase expression in human spermatogenic cell stagesQ59654253
Diet and exercise in an obese mouse fed a high-fat diet improve metabolic health and reverse perturbed sperm functionQ59709679
Regulation of serum leptin levels by gonadal function in ratsQ60693607
Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesityQ61718690
High and low BMI increase the risk of miscarriage after IVF/ICSI and FETQ61841691
Is overweight a risk factor for reduced semen quality and altered serum sex hormone profile?Q61861008
Mouse sperm chromatin proteins: quantitative isolation and partial characterizationQ67691336
Investigation of the mechanism by which insulin-induced hypoglycemia decreases luteinizing hormone secretion in ovariectomized ewesQ68534661
Sequence-specific packaging of DNA in human sperm chromatinQ69004155
Enhanced conversion of androstenedione to estrogens in obese malesQ71332628
Lipectomy in the treatment of scrotal lipomatosisQ71506921
Early onset of reproductive function in normal female mice treated with leptinQ71920050
Control of human spermatogenesis by induced changes of intrascrotal temperatureQ72142962
Response of the seminiferous epithelium of the rat testis to withdrawal of androgen: evidence for direct effect upon intercellular spaces associated with Sertoli cell junctional complexesQ72613465
32P-postlabeling analysis of DNA adducts in human sperm cells from smokers and nonsmokersQ72676294
Stage-dependent changes in spermatogenesis and Sertoli cells in relation to the onset of spermatogenic failure following withdrawal of testosteroneQ72963127
Regulated hyperacetylation of core histones during mouse spermatogenesis: involvement of histone deacetylasesQ73383734
Impact of parental BMI on the manifestation of overweight 5-7 year old childrenQ74445884
Novel association between sperm reactive oxygen species production, sperm morphological defects, and the sperm deformity indexQ76338086
Glucose availability modulates the timing of the luteinizing hormone surge in the eweQ77476897
The hypogonadal-obesity cycle: role of aromatase in modulating the testosterone-estradiol shunt--a major factor in the genesis of morbid obesityQ77794785
Protamine levels vary between individual sperm cells of infertile human males and correlate with viability and DNA integrityQ80000004
Persistent organochlorines, sedentary occupation, obesity and human male subfertilityQ81067520
Sperm DNA damage is associated with assisted reproductive technology pregnancyQ81151003
Obesity in men: the hypogonadal-estrogen receptor relationship and its effect on glucose homeostasisQ81158633
Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic developmentQ81611068
Scrotal thermoregulatory model and assessment of the impairment of scrotal temperature control in varicoceleQ82059348
Identification of diabetes- and obesity-associated proteomic changes in human spermatozoa by difference gel electrophoresisQ82291329
Selenium-enriched probiotics improves murine male fertility compromised by high fat dietQ83153899
Body mass index vis-à-vis total sperm count in attendees of a single andrology clinicQ83395936
Identification of human sperm transcripts as candidate markers of male fertilityQ83899515
[Leptin: a peptide with therapeutic potential in the obese]Q84530011
Obesity and age affect male fertility potentialQ84609424
Semen parameters and sperm DNA fragmentation as causes of recurrent pregnancy lossQ84667492
Oxidative deoxyribonucleic acid damage in sperm has a negative impact on clinical pregnancy rate in intrauterine insemination but not intracytoplasmic sperm injection cyclesQ84757821
SIRT6 in mouse spermatogenesis is modulated by diet-induced obesityQ84837235
The effect of obesity on sperm disorders and male infertilityQ37692815
Does low testosterone affect adaptive properties of adipose tissue in obese men?Q37809061
Diabetes mellitus and sperm parameters.Q37862912
Epigenetic programming by maternal nutrition: shaping future generationsQ37961763
The sperm epigenome and potential implications for the developing embryoQ38001971
Expression of functional leptin receptors in rodent Leydig cellsQ38319039
The stimulatory effect of leptin on the neuroendocrine reproductive axis of the monkeyQ38331850
Leptin treatment rescues the sterility of genetically obese ob/ob malesQ38348234
Diet-induced paternal obesity in the absence of diabetes diminishes the reproductive health of two subsequent generations of miceQ39649343
Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men.Q39697629
Male gonadal dysfunction.Q39847946
Current and future costs of cancer, heart disease and stroke attributable to obesity in Australia - a comparison of two birth cohorts.Q39991586
Intergenerational influences on childhood body mass index: the effect of parental body mass index trajectoriesQ40016227
Analysis of the methylation pattern of six gene promoters in sperm of men with abnormal protaminationQ42141035
Prenatal exposure to ethanol: a specific effect on the H19 gene in spermQ42747085
MicroRNAs control de novo DNA methylation through regulation of transcriptional repressors in mouse embryonic stem cellsQ42808496
Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expressionQ42831643
Associations between parental and offspring adiposity up to midlife: the contribution of adult lifestyle factors in the 1958 British Birth Cohort StudyQ42940264
Effect of obesity on sex hormone levels, antisperm antibodies, and fertility after vasectomy reversalQ43079696
Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men.Q43118139
Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogasterQ43156487
Elevated scrotal temperature, but not varicocele grade, reflects testicular oxidative stress-mediated apoptosisQ43298561
Paternal alcohol exposure affects sperm cytosine methyltransferase messenger RNA levelsQ43940297
Seminal reactive oxygen species as predictors of fertilization, embryo quality and pregnancy rates after conventional in vitro fertilization and intracytoplasmic sperm injectionQ44597373
Transient DNA strand breaks during mouse and human spermiogenesis new insights in stage specificity and link to chromatin remodelingQ44673891
Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.Q44685104
In vivo effects of histone-deacetylase inhibitor trichostatin-A on murine spermatogenesisQ45005818
Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technologyQ45106290
Effect of alcohol consumption on CpG methylation in the differentially methylated regions of H19 and IG-DMR in male gametes: implications for fetal alcohol spectrum disorders.Q45972891
Assisted reproductive technology surveillance--United States, 2006.Q45977156
Semen parameters and hormonal profile in obese fertile and infertile males.Q46021529
Associations between andrological measures, hormones and semen quality in fertile Australian men: inverse relationship between obesity and sperm outputQ46058269
Semen quality and reproductive hormones according to birthweight and body mass index in childhood and adult life: two decades of follow-upQ46071019
Subfecundity in overweight and obese couplesQ46124909
Sperm parameters and male fertility after bariatric surgery: three case seriesQ46229664
An exploration of the association between male body mass index and semen qualityQ46232683
Is semen quality affected by male body fat distribution?Q46787792
Effect of body weight on testosterone/estradiol ratio in oligozoospermic patientsQ46916896
Do reproductive hormones explain the association between body mass index and semen quality?Q46925311
Effect of body weight on sperm concentration in normozoospermic malesQ47374272
Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parametersQ47393915
Serum sex-hormone-binding globulin is related to hepatic and peripheral insulin sensitivity but not to beta-cell function in men and women with Type 2 diabetes mellitusQ47957008
Influence of female bodyweight on IVF outcome: a longitudinal multicentre cohort study of 487 infertile couples.Q48666358
The effect of paternal diet-induced obesity on sperm function and fertilization in a mouse modelQ48694486
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspringQ34144838
Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studiesQ34152384
The essential role of the aromatase/p450aromQ34158697
Overweight men: clinical pregnancy after ART is decreased in IVF but not in ICSI cyclesQ34247398
Understanding transgenerational epigenetic inheritance via the gametes in mammalsQ34250734
Chromatin replication and epigenome maintenanceQ34256428
Transgenerational epigenetic inheritance: more questions than answers.Q34341597
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistanceQ34386993
RNA-mediated non-mendelian inheritance of an epigenetic change in the mouseQ34530513
Physical activity and semen quality among men attending an infertility clinicQ34594287
Germline histone dynamics and epigeneticsQ34623835
Diet-induced obesity in rats leads to a decrease in sperm motilityQ34743620
Great balls of fire and the vicious cycle: a study of the effects of cycling on male fertilityQ34990450
Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal modelsQ35238366
Sperm methylation profiles reveal features of epigenetic inheritance and evolution in primatesQ35499095
The effect of preconception paternal alcohol exposure on epigenetic remodeling of the h19 and rasgrf1 imprinting control regions in mouse offspringQ35771472
The developmental origins of chronic adult disease.Q36035921
Non-coding RNAs: new players in eukaryotic biologyQ36235823
Predictive value of DNA integrity analysis in idiopathic recurrent pregnancy loss following spontaneous conception.Q36295612
DNA integrity is compromised in protamine-deficient human spermQ36314491
Oxidative stress, sperm survival and fertility controlQ36368002
Polycystic ovary syndrome and maternal obesity affect oocyte size in in vitro fertilization/intracytoplasmic sperm injection cyclesQ36935621
Diminished paternity and gonadal function with increasing obesity in menQ37003117
Do heat stress and deficits in DNA repair pathways have a negative impact on male fertility?Q37050787
Diabetes and the impairment of reproductive function: possible role of mitochondria and reactive oxygen species.Q37065906
The metabolic syndrome and male infertilityQ37068386
The effects of acquired paternal obesity on the next generation.Q37084348
Paternal contributions: new functional insights for spermatozoal RNAQ37130381
Hormonal regulation of spermatogenesis and spermiogenesisQ37133546
Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in PomeraniaQ37317410
Parental smoking and childhood leukemiaQ37358022
Spermatozoal RNAs: what about their functions?Q37414143
From meiosis to postmeiotic events: the secrets of histone disappearance.Q37656482
Hormonal regulation of male germ cell development.Q37690032
P433issue4
P921main subjectobesityQ12174
P304page(s)253-263
P577publication date2012-10-01
P1433published inSpermatogenesisQ26842428
P1476titleImpact of obesity on male fertility, sperm function and molecular composition
P478volume2

Reverse relations

cites work (P2860)
Q38429957Abnormalities of Reproductive Function in Male Obesity Before and After Bariatric Surgery-A Comprehensive Review
Q34422367Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress
Q55422786Adipokines in Semen: Physiopathology and Effects on Spermatozoas.
Q41696142Adult exercise effects on oxidative stress and reproductive programming in male offspring of obese rats.
Q48151285Association between body mass index and sperm quality and sperm DNA integrity. A large population study.
Q44054633Basic diagnostics in andrology
Q37195768Characterisation of mouse epididymosomes reveals a complex profile of microRNAs and a potential mechanism for modification of the sperm epigenome.
Q46319237Combined aerobic and resistance exercise training for improving reproductive function in infertile men: a randomized controlled trial
Q64259342Comprehensive and Systematic Analysis of Gene Expression Patterns Associated with Body Mass Index
Q33893456Control of Germline Stem Cell Lineages by Diet and Physiology
Q38552992Deleterious effects of obesity upon the hormonal and molecular mechanisms controlling spermatogenesis and male fertility
Q54946745Di-(2-Ethylhexyl) Phthalate Increases Obesity-Induced Damage to the Male Reproductive System in Mice.
Q38883667Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies
Q35897949Direct effects of leptin and adiponectin on peripheral reproductive tissues: a critical review
Q89287791Downregulation of leptin receptor and kisspeptin/GPR54 in the murine hypothalamus contributes to male hypogonadism caused by high-fat diet-induced obesity
Q39545379Effect of Astaxanthin, Vitamin E, and Vitamin C in Combination with Calorie Restriction on Sperm Quality and Quantity in Male Rats.
Q89821376Effect of Different Exercise Loads on Testicular Oxidative Stress and Reproductive Function in Obese Male Mice
Q92353215Effect of low sperm quality on progeny: a study on zebrafish as model species
Q92476213Effect of postnatal overfeeding on the male and female Wistar rat reproductive parameters
Q48155973Effects of Chronic Musculoskeletal Pain on Fertility Potential in Lean and Overweight Male Patients
Q44241259Effects of leptin on sperm count and morphology in Sprague-Dawley rats and their reversibility following a 6-week recovery period.
Q38226585Epigenetic effects of paternal diet on offspring: emphasis on obesity
Q57066109Estrogen Modulates Glycerol Permeability in Sertoli Cells through Downregulation of Aquaporin-9
Q55256840Evaluation of Diabetogenic Mechanism of High Fat Diet in Combination with Arsenic Exposure in Male Mice.
Q35231264Exploration of the association between obesity and semen quality in a 7630 male population
Q41159217Fathers that are born small program alterations in the next-generation preimplantation rat embryos.
Q35599495Female offspring sired by diet induced obese male mice display impaired blastocyst development with molecular alterations to their ovaries, oocytes and cumulus cells
Q90379238High-intensity interval training modulates male factor infertility through anti-inflammatory and antioxidative mechanisms in infertile men: A randomized controlled trial
Q58090524Impact of Bariatric Surgery on Male Sex Hormones and Sperm Quality: a Systematic Review and Meta-Analysis
Q41222931Intergenerational Transmission of Paternal Epigenetic Marks: Mechanisms Influencing Susceptibility to Post-Concussion Symptomology in a Rodent Model
Q41698910Intra- and inter-individual differences in human sperm DNA methylation
Q40970865Is There an Association Between the Body Mass Index and Interpersonal Violent Behavior?
Q42706670Lactobacillus rhamnosus PB01 (DSM 14870) supplementation affects markers of sperm kinematic parameters in a diet-induced obesity mice model
Q54969898Lifestyle causes of male infertility.
Q38167119Lifestyle, environment, and male reproductive health
Q41471343Long non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity
Q37710206Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice.
Q38675176Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis
Q92924243Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
Q42226730Male Infertility: The Effect of Natural Antioxidants and Phytocompounds on Seminal Oxidative Stress
Q97420637Male Obesity Associated Gonadal Dysfunction and the Role of Bariatric Surgery
Q28396945Mammalian sperm nuclear organization: resiliencies and vulnerabilities
Q39275828Management of weight loss in obesity-associated male infertility: a spotlight on bariatric surgery
Q41694715Maternal obesity and overnutrition increase oxidative stress in male rat offspring reproductive system and decrease fertility
Q35533819Mechanisms linking obesity to male infertility
Q39638677Metabolic syndrome in white European men presenting for primary couple's infertility: investigation of the clinical and reproductive burden
Q89882026Metformin treatment of high-fat diet-fed obese male mice restores sperm function and fetal growth, without requiring weight loss
Q92455034Mitochondrial Involvement in the Adaptive Response to Chronic Exposure to Environmental Pollutants and High-Fat Feeding in a Rat Liver and Testis
Q64106518Non-genetic inheritance via the male germline in mammals
Q64912455Obesity and Hypogonadism-A Narrative Review Highlighting the Need for High-Quality Data in Adolescents.
Q33604664Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort
Q47801247Obesity-Induced Infertility in Male Mice Is Associated With Disruption of Crisp4 Expression and Sperm Fertilization Capacity.
Q38989466Obesogens and male fertility.
Q33888343Overweight in young males reduce fertility in rabbit model.
Q57033514Oxidative Stress in the Male Germline: A Review of Novel Strategies to Reduce 4-Hydroxynonenal Production
Q46496814Parental programming: how can we improve study design to discern the molecular mechanisms?
Q33685949Paternal obesity modifies the effect of an antenatal lifestyle intervention in women who are overweight or obese on newborn anthropometry
Q36748533Peroxisome proliferator-activated receptor gamma signaling in human sperm physiology
Q48585275Preconception diet or exercise intervention in obese fathers normalizes sperm microRNA profile and metabolic syndrome in female offspring.
Q39305273Protective effect of doxycycline on germinal epithelial loss caused by a high-fat diet.
Q49588425Protective effects of rutin against obesity-induced reproductive impairment in male mice
Q28077644Recent advances in understanding & managing male infertility
Q38255588Recent scenario of obesity and male fertility
Q39406203Serum microRNAs in male subfertility-biomarkers and a potential pathogenetic link to metabolic syndrome
Q38826558Sex chromosome-dependent differential viability of human spermatozoa during prolonged incubation.
Q94394629Sperm DNA fragmentation
Q37419363Spermatozoal cell death-inducing DNA fragmentation factor-α-like effector A (CIDEA) gene expression and DNA fragmentation in infertile men with metabolic syndrome and normal seminogram.
Q34209074Sugar-sweetened beverage intake in relation to semen quality and reproductive hormone levels in young men
Q90574192Sulforaphane Protects the Male Reproductive System of Mice from Obesity-Induced Damage: Involvement of Oxidative Stress and Autophagy
Q90175362Testicular volume and clinical correlates of hypothalamic-pituitary-testicular function: A cross-sectional study in obese men
Q92050934The Effect of Macronutrients on Reproductive Hormones in Overweight and Obese Men: A Pilot Study
Q53160248The metabolic response to a high-fat diet reveals obesity-prone and -resistant phenotypes in mice with distinct mRNA-seq transcriptome profiles.
Q46675379The microRNA signature of mouse spermatozoa is substantially modified during epididymal maturation.
Q92983713The relationship between diet, energy balance and fertility in men
Q38213424The role of early life nutrition in programming of reproductive function
Q91783089Transgenerational Epigenetics: A Window into Paternal Health Influences on Offspring
Q93102029Understanding the molecular mechanisms of bisphenol A action in spermatozoa
Q47127834Vitamin D Receptor Gene Haplotype and Late-Onset Obesity in Iranian Azeri Turkish Women

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