A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans

scientific article

A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1534/GENETICS.112.143727
P8608Fatcat IDrelease_ytqd2uxvmfdutb7gavzlnh4yk4
P932PMC publication ID3522167
P698PubMed publication ID22887819

P2093author name stringDiane G Morton
Kenneth J Kemphues
Wendy A Hoose
P2860cites workComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeQ21245891
MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasmQ24296287
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRADQ24305094
The genetics of Caenorhabditis elegansQ24533408
Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stabilityQ24535623
WormBase: a comprehensive resource for nematode researchQ24642944
The Pfam protein families databaseQ24644670
SMART 6: recent updates and new developmentsQ24655795
Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin-conjugating enzymes, ubiquitin-activating enzymes, and ubiquitin-like proteinsQ24802049
Basic local alignment search toolQ25938991
Systematic functional analysis of the Caenorhabditis elegans genome using RNAiQ27860839
Ubc9p is the conjugating enzyme for the ubiquitin-like protein Smt3pQ27930030
Microtubules induce self-organization of polarized PAR domains in Caenorhabditis elegans zygotesQ28116344
A serine/threonine kinase gene defective in Peutz-Jeghers syndromeQ28119198
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinaseQ28258611
C. elegans PAR proteins function by mobilizing and stabilizing asymmetrically localized protein complexesQ28265914
Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegansQ28270015
Proteasome-independent functions of ubiquitin in endocytosis and signalingQ28282959
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryoQ28506665
Expression of Melk, a new protein kinase, during early mouse developmentQ28511671
LKB1 and SAD kinases define a pathway required for the polarization of cortical neuronsQ28591764
Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi libraryQ28770084
P bodies and the control of mRNA translation and degradationQ29547253
Specific interference by ingested dsRNAQ29617516
Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegansQ29618535
Stabilization of cell polarity by the C. elegans RING protein PAR-2.Q30478491
SUMO regulates the assembly and function of a cytoplasmic intermediate filament protein in C. elegansQ30492693
Symmetry breaking and polarization of the C. elegans zygote by the polarity protein PAR-2Q30494245
Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryoQ30496455
The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryoQ30497313
The SAD-1 kinase regulates presynaptic vesicle clustering and axon terminationQ31965163
SUMO, ubiquitin's mysterious cousinQ33939449
par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesisQ33959251
Control of cleavage spindle orientation in Caenorhabditis elegans: the role of the genes par-2 and par-3.Q33964428
Cell polarity in eggs and epithelia: parallels and diversityQ34118022
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetryQ34507504
LKB1-dependent signaling pathwaysQ34535140
Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.Q34543848
Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryosQ47069466
Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle alignment in early C. elegans embryosQ47069501
Depletion of the co-chaperone CDC-37 reveals two modes of PAR-6 cortical association in C. elegans embryosQ47069512
C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress responseQ47069557
Genetic requirements for PIE-1 localization and inhibition of gene expression in the embryonic germ lineage of Caenorhabditis elegansQ47683015
Embryonic lethality caused by mutations in basement membrane collagen of C. elegansQ48235123
Identification of a heat-shock pseudogene from Caenorhabditis elegansQ48300028
Cell cycle regulation of pEg3, a new Xenopus protein kinase of the KIN1/PAR-1/MARK family.Q48871311
Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1.Q51546346
Cell lineages and developmental defects of temperature-sensitive embryonic arrest mutants in Caenorhabditis elegans.Q52298755
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos.Q53495600
An analysis of the role of microfilaments in the establishment and maintenance of asymmetry in Caenorhabditis elegans zygotesQ68123078
Identification of genes required for cytoplasmic localization in early C. elegans embryosQ68273724
Asymmetric movements of cytoplasmic components in Caenorhabditis elegans zygotesQ69227141
Parental effects and phenotypic characterization of mutations that affect early development in Caenorhabditis elegansQ71183744
Generation of asymmetry and segregation of germ-line granules in early C. elegans embryosQ71236703
Systematic, RNA-interference-mediated identification of mus-101 modifier genes in Caenorhabditis elegansQ34572464
A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegansQ35038681
Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegansQ35222713
par-2, a gene required for blastomere asymmetry in Caenorhabditis elegans, encodes zinc-finger and ATP-binding motifsQ35553959
The Caenorhabditis elegans septin complex is nonpolarQ35914622
Programmed elimination of cells by caspase-independent cell extrusion in C. elegansQ36157242
Ubiquitylation and cell signalingQ36251951
Characterization of alpha1(IV) collagen mutations in Caenorhabditis elegans and the effects of alpha1 and alpha2(IV) mutations on type IV collagen distributionQ36262065
Immunofluorescence visualization of germ-line-specific cytoplasmic granules in embryos, larvae, and adults of Caenorhabditis elegansQ36285245
The Caenorhabditis elegans vab-10 spectraplakin isoforms protect the epidermis against internal and external forcesQ36381451
PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.Q36491719
Acto-myosin reorganization and PAR polarity in C. elegansQ36730900
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cellsQ36731904
Two conserved regulatory cytoplasmic poly(A) polymerases, GLD-4 and GLD-2, regulate meiotic progression in C. elegansQ37152250
The art and design of genetic screens: RNA interference.Q37180850
Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1Q37310263
MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryoQ37425052
Elaborating polarity: PAR proteins and the cytoskeletonQ37838101
Role of LKB1-SAD/MARK pathway in neuronal polarizationQ37854547
The multifaceted roles of USP7: new therapeutic opportunitiesQ37862125
The Ccr4--not complexQ37949473
Pseudocleavage is dispensable for polarity and development in C. elegans embryosQ38467112
PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryosQ39758007
LKB1/STRAD promotes axon initiation during neuronal polarization.Q40136806
Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryoQ40483476
Mutations in ooc-5 and ooc-3 disrupt oocyte formation and the reestablishment of asymmetric PAR protein localization in two-cell Caenorhabditis elegans embryosQ41699806
Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phasesQ42149368
The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryoQ43849657
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryosQ44057731
PAR-1 is required for morphogenesis of the Caenorhabditis elegans vulvaQ44254664
The C. elegans MELK ortholog PIG-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions.Q44846511
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.Q45211998
LGL can partition the cortex of one-cell Caenorhabditis elegans embryos into two domainsQ45401297
OOC-3, a novel putative transmembrane protein required for establishment of cortical domains and spindle orientation in the P(1) blastomere of C. elegans embryosQ47068753
PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos.Q47068779
C. elegans STRADalpha and SAD cooperatively regulate neuronal polarity and synaptic organizationQ47068978
par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Q47068999
C. elegans PAR-3 and PAR-6 are required for apicobasal asymmetries associated with cell adhesion and gastrulation.Q47069009
Neuronal polarity is regulated by a direct interaction between a scaffolding protein, Neurabin, and a presynaptic SAD-1 kinase in Caenorhabditis elegansQ47069032
CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.Q47069038
The non-canonical Hop protein from Caenorhabditis elegans exerts essential functions and forms binary complexes with either Hsc70 or Hsp90.Q47069319
Differential requirements for STRAD in LKB1-dependent functions in C. elegans.Q47069379
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectCaenorhabditis elegansQ91703
P1104number of pages14
P304page(s)929-942
P577publication date2012-08-10
P1433published inGeneticsQ3100575
P1476titleA genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans
P478volume192

Reverse relations

cites work (P2860)
Q54210803'Goldilocks' suppressor screen identifies web of polarity regulators.
Q35621410A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis
Q36643905Caenorhabditis elegans PIG-1/MELK acts in a conserved PAR-4/LKB1 polarity pathway to promote asymmetric neuroblast divisions
Q57980365Cell Polarity in One-Cell C. elegans Embryos: Ensuring an Accurate and Precise Spatial Axis During Development
Q27329642Deubiquitylation machinery is required for embryonic polarity in Caenorhabditis elegans
Q43491720LET-99 functions in the astral furrowing pathway, where it is required for myosin enrichment in the contractile ring
Q33973337Noncanonical cell death in the nematode Caenorhabditis elegans
Q27309993PAR-4 and anillin regulate myosin to coordinate spindle and furrow position during asymmetric division.
Q99568699PIG-1 MELK-dependent phosphorylation of nonmuscle myosin II promotes apoptosis through CES-1 Snail partitioning
Q39242272Size Matters: How C. elegans Asymmetric Divisions Regulate Apoptosis
Q26860998The PAR network: redundancy and robustness in a symmetry-breaking system
Q91433684The kinases PIG-1 and PAR-1 act in redundant pathways to regulate asymmetric division in the EMS blastomere of C. elegans
Q38161449Wnt-signaling and planar cell polarity genes regulate axon guidance along the anteroposterior axis in C. elegans

Search more.