Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma

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Integrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma is …
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scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-11-1431
P932PMC publication ID3523177
P698PubMed publication ID22328562
P5875ResearchGate publication ID221826893

P2093author name stringLin Lin
David G Beer
William W Lockwood
Kelsie L Thu
Larissa A Pikor
Raj Chari
Wan L Lam
P2860cites workLarge-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approachQ24297923
Barrett's oesophagus and oesophageal adenocarcinoma: time for a new synthesisQ24602426
E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpointsQ24672780
Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinomaQ24681972
Epidemiology and pathogenesis of esophageal cancerQ28213313
Cancer statistics, 2009Q29547625
Assessing the significance of chromosomal aberrations in cancer: methodology and application to gliomaQ30014823
Comparative genomic hybridization of esophageal and gastroesophageal adenocarcinomas shows consensus areas of DNA gain and lossQ30472348
Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequenceQ30837765
Integrative genomic analyses identify BRF2 as a novel lineage-specific oncogene in lung squamous cell carcinomaQ33644421
Integrative analysis of array-comparative genomic hybridisation and matched gene expression profiling data reveals novel genes with prognostic significance in oesophageal adenocarcinomaQ33866777
Single nucleotide polymorphism-based genome-wide chromosome copy change, loss of heterozygosity, and aneuploidy in Barrett's esophagus neoplastic progressionQ33902184
The molecular and cellular biology of HER2/neu gene amplification/overexpression and the clinical development of herceptin (trastuzumab) therapy for breast cancer.Q34007817
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancersQ34460542
Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomasQ34578434
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursorsQ35163647
A comprehensive analysis of common copy-number variations in the human genomeQ35616521
Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinomaQ37198249
Chromosomal abnormalities and novel disease-related regions in progression from Barrett's esophagus to esophageal adenocarcinomaQ37398079
Genome-wide catalogue of chromosomal aberrations in barrett's esophagus and esophageal adenocarcinoma: a high-density single nucleotide polymorphism array analysis.Q37599640
Direct recruitment of N-myc to target gene promotersQ38306777
Identification of target genes of the p16INK4A-pRB-E2F pathway.Q38351396
Analysis of the premalignant stages of Barrett's oesophagus through to adenocarcinoma by comparative genomic hybridizationQ38454443
Clonal analysis of a case of multifocal oesophageal (Barrett's) adenocarcinoma by comparative genomic hybridizationQ38467829
Replication factor C3 of Schizosaccharomyces pombe, a small subunit of replication factor C complex, plays a role in both replication and damage checkpointsQ38615231
DNA amplification is a ubiquitous mechanism of oncogene activation in lung and other cancers.Q39902217
The knockdown of endogenous replication factor C4 decreases the growth and enhances the chemosensitivity of hepatocellular carcinoma cellsQ40089822
Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repressionQ40263007
Comparative genomic hybridization of esophageal adenocarcinoma and squamous cell carcinoma cell linesQ40338740
A 4-gene signature predicts survival of patients with resected adenocarcinoma of the esophagus, junction, and gastric cardiaQ42973684
Mutational and expressional analysis of RFC3, a clamp loader in DNA replication, in gastric and colorectal cancersQ43646679
ATP utilization by yeast replication factor C. III. The ATP-binding domains of Rfc2, Rfc3, and Rfc4 are essential for DNA recognition and clamp loadingQ43658427
Expression profiles of SV40-immortalization-associated genes upregulated in various human cancersQ44710652
Genetic profiles of gastroesophageal cancer: combined analysis using expression array and tiling array--comparative genomic hybridizationQ46246189
Progression of Barrett's metaplasia to adenocarcinoma is associated with the suppression of the transcriptional programs of epidermal differentiation.Q53358861
Genomic alterations in malignant transformation of Barrett's esophagus.Q53399672
DNA copy number alterations correlate with survival of esophageal adenocarcinoma patients.Q54514233
Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism ArraysQ57742895
Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arraysQ60056792
DNA copy number profiling in esophageal Barrett adenocarcinoma: comparison with gastric adenocarcinoma and esophageal squamous cell carcinomaQ74025303
A tiling resolution DNA microarray with complete coverage of the human genomeQ76380637
Comparative genomic hybridization of cancer of the gastroesophageal junction: deletion of 14Q31-32.1 discriminates between esophageal (Barrett's) and gastric cardia adenocarcinomasQ78109218
The replication factor C clamp loader requires arginine finger sensors to drive DNA binding and proliferating cell nuclear antigen loadingQ80276217
The role of overdiagnosis and reclassification in the marked increase of esophageal adenocarcinoma incidenceQ81290009
Identification of candidate molecular markers of nasopharyngeal carcinoma by tissue microarray and in situ hybridizationQ82352444
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectgenomicsQ222046
adenocarcinomaQ356033
P304page(s)1936-1946
P577publication date2012-02-10
P1433published inClinical Cancer ResearchQ332253
P1476titleIntegrative genomics identified RFC3 as an amplified candidate oncogene in esophageal adenocarcinoma
P478volume18

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cites work (P2860)
Q47792677A unique gene expression signature is significantly differentially expressed in tumor-positive or tumor-negative sentinel lymph nodes in patients with melanoma
Q51039462Detection of coding microsatellite frameshift mutations in DNA mismatch repair-deficient mouse intestinal tumors.
Q52624753Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.
Q88993477HNRNPLL stabilizes mRNA for DNA replication proteins and promotes cell cycle progression in colorectal cancer cells
Q42030667Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties
Q57144495Identification of RFC5 as a novel potential prognostic biomarker in lung cancer through bioinformatics analysis
Q54324221Identification of a subset of patients with acute myeloid leukemia characterized by long-term in vitro proliferation and altered cell cycle regulation of the leukemic cells.
Q55347847Identification of key pathways and genes in the progression of cervical cancer using bioinformatics analysis.
Q91994556Key Molecular Events in Cervical Cancer Development
Q34636473Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer
Q34820809MALDI imaging on large-scale tissue microarrays identifies molecular features associated with tumour phenotype in oesophageal cancer.
Q35871650Multi-Scale Genomic, Transcriptomic and Proteomic Analysis of Colorectal Cancer Cell Lines to Identify Novel Biomarkers
Q58804597Multifaceted regulation and functions of replication factor C family in human cancers
Q44496287Overexpression of RFC3 is correlated with ovarian tumor development and poor prognosis
Q38925416Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.
Q39210861SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling
Q36095110ShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation
Q90350507Targeting Hippo coactivator YAP1 through BET bromodomain inhibition in esophageal adenocarcinoma
Q37439591Up-Regulation of RFC3 Promotes Triple Negative Breast Cancer Metastasis and is Associated With Poor Prognosis Via EMT.
Q37649231YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway.
Q90054171pathCHEMO, a generalizable computational framework uncovers molecular pathways of chemoresistance in lung adenocarcinoma

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