| scholarly article | Q13442814 |
| P356 | DOI | 10.1080/03602530600569810 |
| P698 | PubMed publication ID | 16684647 |
| P50 | author | Nick Plant | Q42717895 |
| P2093 | author name string | Anna Phillips | |
| G Gordon Gibson | |||
| Sihem Aouabdi | |||
| Kate Plant | |||
| P2860 | cites work | 2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin | Q24294476 |
| The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions | Q24310512 | ||
| TRANSFAC: a database on transcription factors and their DNA binding sites | Q24545748 | ||
| Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms | Q24548411 | ||
| Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia | Q24558647 | ||
| Genomic analysis of the nuclear receptor family: new insights into structure, regulation, and evolution from the rat genome | Q24598049 | ||
| The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity | Q24630723 | ||
| Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction | Q24646162 | ||
| Alternatively spliced isoforms of the human constitutive androstane receptor | Q24679627 | ||
| The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity | Q27632611 | ||
| The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands | Q27641458 | ||
| Generation of multiple farnesoid-X-receptor isoforms through the use of alternative promoters | Q28204305 | ||
| Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin | Q28211706 | ||
| Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital | Q28212942 | ||
| Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes | Q28213013 | ||
| Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels | Q28217854 | ||
| PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators | Q28281902 | ||
| A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro | Q28374353 | ||
| Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands | Q28375193 | ||
| Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene | Q30732627 | ||
| Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury | Q33838275 | ||
| Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR). | Q34161577 | ||
| Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes | Q34184221 | ||
| Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man. | Q34604457 | ||
| Liver X receptor agonists as potential therapeutic agents for dyslipidemia and atherosclerosis | Q35077373 | ||
| Beyond the human genome: examples of nuclear receptor analysis in model organisms and potential for drug discovery | Q35566790 | ||
| Virtual gating and nuclear transport: the hole picture | Q35587487 | ||
| Induction of drug metabolism: the role of nuclear receptors. | Q35600898 | ||
| Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR. | Q35974420 | ||
| Nuclear receptors and drug disposition gene regulation | Q36109707 | ||
| Structure and function of the human nuclear xenobiotic receptor PXR. | Q36230608 | ||
| Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression. | Q37120639 | ||
| Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue | Q38360929 | ||
| Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR. | Q40358831 | ||
| Statins and transcriptional regulation: the FXR connection | Q40399071 | ||
| Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. | Q40440482 | ||
| Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression | Q40496439 | ||
| Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver | Q40519268 | ||
| Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene | Q40564436 | ||
| Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region | Q40601663 | ||
| Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5'-flanking region | Q40609924 | ||
| Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor | Q40768989 | ||
| Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450. | Q40785589 | ||
| Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor | Q43779017 | ||
| Induction of cytochrome P450 3A4 in primary human hepatocytes and activation of the human pregnane X receptor by tamoxifen and 4-hydroxytamoxifen | Q43957743 | ||
| Insights from a three-dimensional model into ligand binding to constitutive active receptor | Q44094332 | ||
| Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element | Q44094369 | ||
| Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification | Q44104285 | ||
| Receptor-dependent regulation of the CYP3A4 gene | Q44264829 | ||
| Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development | Q44458169 | ||
| Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells | Q44534142 | ||
| CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor | Q44717276 | ||
| A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification | Q44741483 | ||
| Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice | Q45201689 | ||
| Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C. | Q45264564 | ||
| Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice | Q45279418 | ||
| Clofibrate and perfluorodecanoate both upregulate the expression of the pregnane X receptor but oppositely affect its ligand-dependent induction on cytochrome P450 3A23. | Q46434680 | ||
| 5' diversity of human hepatic PXR (NR1I2) transcripts and identification of the major transcription initiation site | Q46597568 | ||
| Functionally conserved xenobiotic responsive enhancer in cytochrome P450 3A7. | Q48383368 | ||
| Interaction networks: coordinating responses to xenobiotic exposure | Q58417446 | ||
| A canonical structure for the ligand-binding domain of nuclear receptors | Q61818643 | ||
| Rat pregnane X receptor: molecular cloning, tissue distribution, and xenobiotic regulation | Q78025580 | ||
| Molecular modelling of the human glucocorticoid receptor (hGR) ligand-binding domain (LBD) by homology with the human estrogen receptor alpha (hERalpha) LBD: quantitative structure-activity relationships within a series of CYP3A4 inducers where indu | Q78644003 | ||
| P433 | issue | 1-2 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 31-49 | |
| P577 | publication date | 2006-01-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Drug Metabolism Reviews | Q5308857 |
| P1476 | title | Transcriptional regulation of the human pregnane-X receptor | |
| P478 | volume | 38 |
| Q28477056 | A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile |
| Q33742134 | Activation of xenobiotic receptors: driving into the nucleus |
| Q43064767 | Comparison of the induction profile for drug disposition proteins by typical nuclear receptor activators in human hepatic and intestinal cells |
| Q36288161 | Corepressors of agonist-bound nuclear receptors |
| Q47158582 | Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics |
| Q37033102 | Long-range regulatory synergy is required to allow control of the TAC1 locus by MEK/ERK signalling in sensory neurones |
| Q89140618 | Mathematical Models in the Description of Pregnane X Receptor (PXR)-Regulated Cytochrome P450 Enzyme Induction |
| Q37557625 | Nuclear receptors: the controlling force in drug metabolism of the liver? |
| Q28397689 | Optimization of stress response through the nuclear receptor-mediated cortisol signalling network |
| Q39542449 | Rifampin and digoxin induction of MDR1 expression and function in human intestinal (T84) epithelial cells. |
| Q36788404 | Role of signalling systems in the effects of dietary factors on the expression of mammalian CYPs |
| Q93054292 | The 3'-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids |
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