Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamate

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Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamate is …
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scholarly articleQ13442814

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P356DOI10.1152/JAPPLPHYSIOL.00912.2012
P932PMC publication ID3524670
P698PubMed publication ID22984242
P5875ResearchGate publication ID230864905

P50authorEduardo ColombariQ43281373
P2093author name stringGlenn M Toney
Leonardo M Cardoso
P2860cites workWater deprivation activates a glutamatergic projection from the hypothalamic paraventricular nucleus to the rostral ventrolateral medullaQ30436344
gamma-Aminobutyric acid (GABA)--A function and binding in the paraventricular nucleus of the hypothalamus in chronic renal-wrap hypertensionQ32072187
In vivo discharge properties of hypothalamic paraventricular nucleus neurons with axonal projections to the rostral ventrolateral medullaQ33593562
Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertensionQ34085600
What does the brain know about blood pressure?Q34446723
Selective modulation of NMDA responses by reduction and oxidationQ34517730
Inhibitory-excitatory synaptic balance is shifted toward increased excitation in magnocellular neurosecretory cells of heart failure rats.Q35217638
Redox signaling in central neural regulation of cardiovascular functionQ35652375
Enhanced activation of RVLM-projecting PVN neurons in rats with chronic heart failureQ35900932
H2O2: a dynamic neuromodulatorQ35975966
Transient receptor potential vanilloid type 1-dependent regulation of liver-related neurons in the paraventricular nucleus of the hypothalamus diminished in the type 1 diabetic mouseQ35976725
Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questionsQ36107869
The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunctionQ81274545
Central antioxidant therapy inhibits parasympathetic baroreflex control in conscious ratsQ82786870
Switch to glutamate receptor 2-lacking AMPA receptors increases neuronal excitability in hypothalamus and sympathetic drive in hypertensionQ36594018
Organum vasculosum laminae terminalis contributes to increased sympathetic nerve activity induced by central hyperosmolalityQ36617591
Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleusQ36632153
Angiotensin II excites paraventricular nucleus neurons that innervate the rostral ventrolateral medulla: an in vitro patch-clamp study in brain slicesQ36921929
Cardiovascular responses to hydrogen peroxide into the nucleus tractus solitariusQ37298425
Neurobiology of overeating and obesity: the role of melanocortins and beyond.Q37835897
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptorsQ38333365
Glutamate and aspartate immunoreactivity in hypothalamic presynaptic axonsQ39243492
Role of the hypothalamic PVN in the reflex reduction in mesenteric blood flow elicited by hyperthermiaQ40406690
Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat.Q41742578
Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failureQ41860459
Identification and characterization of two functionally distinct groups of spinal cord-projecting paraventricular nucleus neurons with sympathetic-related activityQ42440195
Mitochondrial dysfunction and mitochondrial-produced reactive oxygen species: new targets for neurogenic hypertension?Q43116432
Oxygen free radicals regulate NMDA receptor function via a redox modulatory siteQ43512207
AT(1)-receptor blockade in the hypothalamic PVN reduces central hyperosmolality-induced renal sympathoexcitationQ43797576
Reduced endogenous GABA-mediated inhibition in the PVN on renal nerve discharge in rats with heart failureQ43917405
The renin-angiotensin-aldosterone system excites hypothalamic paraventricular nucleus neurons in heart failureQ44027053
Superoxide mediates the actions of angiotensin II in the central nervous system.Q44232559
Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptorsQ44538268
Alteration of NMDA NR1 receptors within the paraventricular nucleus of hypothalamus in rats with heart failureQ44630419
Hypertension caused by angiotensin II infusion involves increased superoxide production in the central nervous systemQ44932501
Hypothalamic paraventricular nucleus differentially supports lumbar and renal sympathetic outflow in water-deprived ratsQ45195691
Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neuronsQ45244950
Role of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors in the cardiovascular effects of L-glutamate microinjection into the hypothalamic paraventricular nucleus of unanesthetized ratsQ46115974
Median preoptic neurones projecting to the hypothalamic paraventricular nucleus respond to osmotic, circulating Ang II and baroreceptor input in the rat.Q46635642
Hydraulically coupled microejection technique for precise local solution delivery in tissuesQ46952345
Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytesQ48135996
Endogenous hydrogen peroxide in paraventricular nucleus mediating cardiac sympathetic afferent reflex and regulating sympathetic activityQ48227983
Endogenous hydrogen peroxide in paraventricular nucleus mediates sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive ratsQ48233757
Glutamatergic inputs in the hypothalamic paraventricular nucleus maintain sympathetic vasomotor tone in hypertensionQ48268840
Local glutamatergic and GABAergic synaptic circuits and metabotropic glutamate receptors in the hypothalamic paraventricular and supraoptic nucleiQ48279064
A comparison of hypotensive and non-hypotensive hemorrhage on Fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla.Q48285903
AT(1) and glutamatergic receptors in paraventricular nucleus support blood pressure during water deprivationQ48329753
Reduced GABA inhibition of sympathetic function in renal-wrapped hypertensive ratsQ48365582
Fos, RVLM-projecting neurons, and spinally projecting neurons in the PVN following hypertonic saline infusionQ48369653
Control of sympathetic outflows by the hypothalamic paraventricular nucleusQ48425663
Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamusQ48459076
Increased osmolality of conscious water-deprived rats supports arterial pressure and sympathetic activity via a brain actionQ48502384
Dose- and time-dependent effect of an acute 3-amino-1,2,4-triazole injection on rat brain catalase activityQ48689710
Physiological Evidence for Local Excitatory Synaptic Circuits in the Rat HypothalamusQ48692854
Inhibition of central angiotensin II-induced pressor responses by hydrogen peroxideQ60441380
Hyperoxia increases H2O2 production by brain in vivoQ69221867
Hydrogen peroxide induces a long-lasting inhibition of the Ca(2+)-dependent glutamate release in cerebrocortical synaptosomes without interfering with cytosolic Ca2+Q72261178
Mechanisms underlying H(2)O(2)-mediated inhibition of synaptic transmission in rat hippocampal slicesQ73134780
Production of catalase changes in animals with 3-amino-1, 2, 4-triazoleQ73806304
The reaction between aminotriazole and catalaseQ79032182
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)1423-1431
P577publication date2012-09-13
P1433published inJournal of Applied PhysiologyQ1091719
P1476titleEndogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamate
P478volume113

Reverse relations

cites work (P2860)
Q42005488Ang II-salt hypertension depends on neuronal activity in the hypothalamic paraventricular nucleus but not on local actions of tumor necrosis factor-α.
Q95933778Anti-hypertensive effect of hydrogen peroxide acting centrally
Q42412882H₂O₂ induces delayed hyperexcitability in nucleus tractus solitarii neurons.
Q61812348Moxibustion Modulates Sympathoexcitatory Cardiovascular Reflex Responses Through Paraventricular Nucleus
Q28070007Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

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