Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma

scientific article

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.15252/EMMM.201505505
P932PMC publication ID4718155
P698PubMed publication ID26666269
P5875ResearchGate publication ID287203983

P50authorEvelyn UllrichQ57151918
Michel MittelbronnQ66360687
Jens SchittenhelmQ40386452
Patrick N. HarterQ47167318
P2093author name stringAlexander Scholz
Jörg Trojan
Matthias Meinhardt
Christian Braun
Roland Goldbrunner
Ulrich Herrlinger
Karl H Plate
Joachim P Steinbach
Martina Deckert
Astrid Weyerbrock
Dietmar Krex
Marco Timmer
Yvonne Reiss
Martin Glas
Oliver Bähr
Peter Baumgarten
Sebastian Cremer
Jochen T Frueh
Maiko Yamaji
Mariangela Di Tacchio
Burak H Yalcin
Kathleen Sommer
Stefanie Gurnik
P2860cites workDouble antiangiogenic protein, DAAP, targeting VEGF-A and angiopoietins in tumor angiogenesis, metastasis, and vascular leakageQ24295214
Anti-PlGF inhibits growth of VEGF(R)-inhibitor-resistant tumors without affecting healthy vesselsQ24299513
VEGF-Trap: a VEGF blocker with potent antitumor effectsQ24535043
Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vesselsQ24644150
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1Q24651548
The 2007 WHO classification of tumours of the central nervous systemQ24685772
Profile of trebananib (AMG386) and its potential in the treatment of ovarian cancerQ26991997
Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapyQ27690653
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancerQ27860681
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastomaQ27860910
Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homingQ28247010
Angiopoietin signaling in the vasculatureQ28287317
Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2Q28570936
Molecular mechanisms and clinical applications of angiogenesisQ29547314
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Microenvironmental regulation of tumor progression and metastasisQ29615504
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesisQ29619677
A randomized trial of bevacizumab for newly diagnosed glioblastomaQ30410163
Epidemiology and etiology of gliomasQ30981828
A novel angiopoietin-2 selective fully human antibody with potent anti-tumoral and anti-angiogenic efficacy and superior side effect profile compared to Pan-Angiopoietin-1/-2 inhibitorsQ31110832
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial.Q33416502
Spatio-temporal deleted in colorectal cancer (DCC) and netrin-1 expression in human foetal brain development.Q33626908
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growthQ33732486
Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumorsQ33765767
Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancerQ34266010
Angiopoietin-2-driven vascular remodeling in airway inflammationQ34358380
Antiangiogenic therapy for glioblastoma: current status and future prospectsQ34523319
Macrophage regulation of tumor responses to anticancer therapiesQ34649588
CSF-1R inhibition alters macrophage polarization and blocks glioma progressionQ34993852
Angiopoietin-2 impairs revascularization after limb ischemiaQ80412365
VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cellsQ82264553
Angiopoietin-2 promotes myeloid cell infiltration in a β₂-integrin-dependent mannerQ84831062
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibitionQ85428242
Anti-angiopoietin therapy with trebananib for recurrent ovarian cancer (TRINOVA-1): a randomised, multicentre, double-blind, placebo-controlled phase 3 trialQ88123697
Context-Dependent Role of Angiopoietin-1 Inhibition in the Suppression of Angiogenesis and Tumor Growth: Implications for AMG 386, an Angiopoietin-1/2–Neutralizing PeptibodyQ35604097
Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasisQ35842980
Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapyQ36378276
Patients With Proneural Glioblastoma May Derive Overall Survival Benefit From the Addition of Bevacizumab to First-Line Radiotherapy and Temozolomide: Retrospective Analysis of the AVAglio TrialQ37240846
Perivascular M2 Macrophages Stimulate Tumor Relapse after ChemotherapyQ37258307
On-site education of VEGF-recruited monocytes improves their performance as angiogenic and arteriogenic accessory cells.Q37322198
Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie systemQ37398561
FDA drug approval summary: bevacizumab (Avastin) as treatment of recurrent glioblastoma multiformeQ37629395
Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapyQ38087230
Tumor-associated macrophages: functional diversity, clinical significance, and open questionsQ38105286
Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancerQ38125964
Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammationQ38379274
Lack of evidence for PlGF mediating the tumor resistance after anti-angiogenic therapy in malignant gliomasQ38942748
VEGF regulates region-specific localization of perivascular bone marrow-derived cells in glioblastomaQ38995812
Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacyQ39085620
MEDI3617, a human anti-angiopoietin 2 monoclonal antibody, inhibits angiogenesis and tumor growth in human tumor xenograft modelsQ39397775
Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.Q39582827
Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growthQ39608133
PlGF blockade does not inhibit angiogenesis during primary tumor growthQ39718360
Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells.Q40100311
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases.Q40479307
Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesisQ41836015
Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.Q43041612
A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical modelsQ44277060
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.Q45866300
Identification and analysis of in vivo VEGF downstream markers link VEGF pathway activity with efficacy of anti-VEGF therapies.Q45981705
An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapyQ46538900
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastomaQ46796397
Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammationQ46931416
In situ expression of angiopoietins in astrocytomas identifies angiopoietin-2 as an early marker of tumor angiogenesisQ48100987
Angiopoietin-2 levels are associated with disease progression in metastatic malignant melanoma.Q51812262
Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain.Q52646854
Serum angiopoietin-2 as a clinical marker for lung cancer.Q53570593
Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.Q54597476
Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.Q55072288
Flt-1 signaling in macrophages promotes glioma growth in vivo.Q55465812
Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.Q55476886
P433issue1
P921main subjectendotheliumQ111140
bevacizumabQ413299
P304page(s)39-57
P577publication date2015-12-14
P1433published inEMBO Molecular MedicineQ15817279
P1476titleEndothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma
P478volume8

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cites work (P2860)
Q51731320A Chimeric Antibody against ACKR3/CXCR7 in Combination with TMZ Activates Immune Responses and Extends Survival in Mouse GBM Models.
Q41574359A Review of Anti-Angiogenic Targets for Monoclonal Antibody Cancer Therapy
Q88095611An In Vivo Blood-brain Barrier Permeability Assay in Mice Using Fluorescently Labeled Tracers
Q50216662Angiopoietin-2 as a Biomarker and Target for Immune Checkpoint Therapy
Q27322343Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling
Q28070234Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems
Q37138981Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2.
Q91670709CAR-Engineered NK Cells for the Treatment of Glioblastoma: Turning Innate Effectors Into Precision Tools for Cancer Immunotherapy
Q90699218Comprehensive review of targeted therapy for colorectal cancer
Q64055896Differential Effects of Ang-2/VEGF-A Inhibiting Antibodies in Combination with Radio- or Chemotherapy in Glioma
Q38707904Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade.
Q55012033Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer.
Q55190117Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges.
Q48093248Functional morphology of the blood-brain barrier in health and disease.
Q64912516Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation.
Q94410269Highlights from the Literature
Q55456947IDH-mutation Status is Associated with Distinct Vascular Gene Expression Signatures in Lower Grade Gliomas.
Q52719932IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma.
Q50055217Improving immunotherapy outcomes with anti-angiogenic treatments and vice versa
Q92998941Intravital 2-photon imaging reveals distinct morphology and infiltrative properties of glioblastoma-associated macrophages
Q38765212Limited role for transforming growth factor-β pathway activation-mediated escape from VEGF inhibition in murine glioma models.
Q33853991Macrophage migration inhibitory factor downregulation: a novel mechanism of resistance to anti-angiogenic therapy
Q39433862Microenvironmental regulation of tumour angiogenesis
Q55349951Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial.
Q90356200Mutual concessions and compromises between stromal cells and cancer cells: driving tumor development and drug resistance
Q94599572N-AS-triggered SPMs are direct regulators of microglia in a model of Alzheimer's disease
Q39022941New Directions in Anti-Angiogenic Therapy for Glioblastoma
Q38736319Novel TIE-2 inhibitor BAY-826 displays in vivo efficacy in experimental syngeneic murine glioma models
Q92334728Optimized antiangiogenic reprogramming of the tumor microenvironment potentiates CD40 immunotherapy
Q28070053Pericytes, an overlooked player in vascular pathobiology
Q48369496Phase 2 and biomarker study of trebananib, an angiopoietin-blocking peptibody, with and without bevacizumab for patients with recurrent glioblastoma.
Q90347558Resistance Mechanisms to Anti-angiogenic Therapies in Cancer
Q52579594Resistance to Anti-Angiogenic Therapy in Cancer-Alterations to Anti-VEGF Pathway.
Q92772956Risk of Adverse Vascular Events in Patients with Malignant Glioma Treated with Bevacizumab Plus Irinotecan: A Systematic Review and Meta-Analysis
Q53082876Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality.
Q92446657Targeting Angiogenesis in Prostate Cancer
Q37567174The brain-penetrating CXCR4 antagonist, PRX177561, increases the antitumor effects of bevacizumab and sunitinib in preclinical models of human glioblastoma
Q38675589The contribution of tumor-associated macrophages in glioma neo-angiogenesis and implications for anti-angiogenic strategies
Q90911537The pro-tumorigenic host response to cancer therapies
Q52645823The role of tumor microenvironment in resistance to anti-angiogenic therapy.
Q39321127Therapeutic targeting of the angiopoietin-TIE pathway
Q90173116Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma
Q90632936Tumor Endothelial Heterogeneity in Cancer Progression
Q91997710Vessel co-option in cancer

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