The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors

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The propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1985PNAS...82.6109P
P356DOI10.1073/PNAS.82.18.6109
P932PMC publication ID390709
P698PubMed publication ID3875856
P5875ResearchGate publication ID19285795

P2093author name stringP A Price
L C Pan
P2860cites workPurification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-CelluloseQ24563043
Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseQ26778460
57 Sequencing end-labeled DNA with base-specific chemical cleavagesQ27860479
Efficient isolation of genes by using antibody probesQ27860543
Screening λgt Recombinant Clones by Hybridization to Single Plaques in SituQ27860770
3' non-coding region sequences in eukaryotic messenger RNAQ27860858
Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase IQ27860885
2 New M13 vectors for cloningQ27861042
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primersQ28131744
Chromogenic Immuno detection of Human Serum Albumin and α-l-Fucosidase Clones in a Human Hepatoma cDNA Expression LibraryQ28259647
Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residueQ28646345
Yeast RNA Polymerase II Genes: Isolation with Antibody ProbesQ29620173
Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coliQ34691657
Electrophoretic patterns of deadenylylated chorion and globin mRNAsQ35084856
The use of heparin as a simple cost-effective means of controlling background In nudeic acid hybridization proceduresQ35432023
The sequence of human serum albumin cDNA and its expression in E. coliQ35746030
Excessive mineralization with growth plate closure in rats on chronic warfarin treatmentQ36326661
Complete nucleotide sequence of a 23S ribosomal RNA gene from Escherichia coliQ36350964
Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasmaQ36364907
Sequence data handling by computerQ36580204
Cloning and sequencing of liver cDNA coding for bovine protein CQ36586896
Characterization of bovine prothrombin mRNA and its translation productQ36598827
Blood coagulation factor X mRNA encodes a single polypeptide chain containing a prepro leader sequenceQ36599093
Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor regionQ37587857
Compilation of published signal sequencesQ40183120
Isolation of a human anti-haemophilic factor IX cDNA clone using a unique 52-base synthetic oligonucleotide probe deduced from the amino acid sequence of bovine factor IX.Q40490963
Further procedures for sequence analysis by computerQ40572935
Translocation of proteins across membranes: the signal hypothesis and beyondQ41032385
Vitamin K-dependent carboxylase: Requirements for carboxylation of soluble peptide substrates and substrate specificityQ41480087
Parathyroid hormone-responsive clonal cell lines from rat osteosarcomaQ42800288
Similar amino acid sequences: chance or common ancestry?Q51198296
Developmental appearance of the vitamin K-dependent protein of bone during calcification. Analysis of mineralizing tissues in human, calf, and rat.Q52293877
How signal sequences maintain cleavage specificityQ57381692
Primary structure of monkey osteocalcin.Q64885098
Partial purification of bovine liver vitamin K-dependent carboxylase by immunospecific adsorption onto antifactor XQ67300902
The vitamin K-dependent bone protein is accumulated within cultured osteosarcoma cells in the presence of the vitamin K antagonist warfarinQ69865314
Concurrent warfarin treatment further reduces bone mineral levels in 1,25-dihydroxyvitamin D3-treated ratsQ70986872
Absence of the vitamin K-dependent bone protein in fetal rat mineral. Evidence for another gamma-carboxyglutamic acid-containing component in boneQ72073676
Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cells. Evidence for an intracellular precursorQ72077073
1,25-Dihydroxyvitamin D3 increases synthesis of the vitamin K-dependent bone protein by osteosarcoma cellsQ72082446
1,25-dihydroxyvitamin D3 increases serum levels of the vitamin K-dependent bone proteinQ72091052
Origin of the vitamin K-dependent bone protein found in plasma and its clearance by kidney and boneQ72098548
Blood coagulationQ72147522
Vitamin K dependent carboxylase: subcellular location of the carboxylase and enzymes involved in Vitamin K metabolism in rat liverQ72848541
P433issue18
P407language of work or nameEnglishQ1860
P921main subjectvitamin KQ182338
P304page(s)6109-6113
P577publication date1985-09-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleThe propeptide of rat bone gamma-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors
P478volume82

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cites work (P2860)
Q38569603A conformational investigation of propeptide binding to the integral membrane protein γ-glutamyl carboxylase using nanodisc hydrogen exchange mass spectrometry
Q37360472A mutation in the propeptide of Factor IX leads to warfarin sensitivity by a novel mechanism
Q21245726BGLAP is expressed in pancreatic cancer cells and increases their growth and invasion
Q44064526Carboxylator: incorporating solvent-accessible surface area for identifying protein carboxylation sites
Q34587707Cloning and characterization of human liver cDNA encoding a protein S precursor
Q28566370Cloning and sequence analysis of rat bone sialoprotein (osteopontin) cDNA reveals an Arg-Gly-Asp cell-binding sequence
Q45884902Defective propeptide processing and abnormal activation underlie the molecular pathology of factor IX Troed-y-Rhiw
Q43109200Dietary phylloquinone intakes and metabolic syndrome in US young adults
Q64105176Engineering, and production of functionally active human Furin in N. benthamiana plant: In vivo post-translational processing of target proteins by Furin in plants
Q24556563Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site
Q36528455Expression of bovine vitamin K-dependent carboxylase activity in baculovirus-infected insect cells
Q40986665Expression of dentin sialoprotein (DSP) and other molecular determinants by a new cell line from dental papillae, MDPC-23.
Q67992187Expression of mRNA of parathyroid hormone-related peptide in fetal bones of the rat
Q67991380Fracture healing induces expression of the proto-oncogene c-fos in vivo. Possible involvement of the Fos protein in osteoblastic differentiation
Q39074534Functional Study of the Vitamin K Cycle Enzymes in Live Cells
Q38860655Functional expression of the human coagulation factor IX using heterologous signal peptide and propeptide sequences in mammalian cell line.
Q24527353Gamma-carboxyglutamate-containing proteins and the vitamin K-dependent carboxylase
Q38748938Gla-containing proteins of bone
Q42157386Group D prothrombin activators from snake venom are structural homologues of mammalian blood coagulation factor Xa.
Q77297028Growth hormone and the expression of mRNAs for matrix proteins and oncogenes in bone
Q28308080Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants
Q37431804Identification and purification to near homogeneity of the vitamin K-dependent carboxylase
Q93111419In silico analysis of missense mutations in exons 1-5 of the F9 gene that cause hemophilia B
Q41739457Induction of matrix Gla protein synthesis during prolonged 1,25-dihydroxyvitamin D3 treatment of osteosarcoma cells
Q34174956Investigation and identification of protein γ-glutamyl carboxylation sites
Q24308815Isolation and molecular cloning of a novel bone phosphoprotein related in sequence to the cystatin family of thiol protease inhibitors
Q41833637Isolation of the human gene for bone gla protein utilizing mouse and rat cDNA clones
Q28114955Modification of the N-terminus of human factor IX by defective propeptide cleavage or acetylation results in a destabilized calcium-induced conformation: effects on phospholipid binding and activation by factor XIa
Q37711728Molecular basis of gamma-carboxylation. Role of the propeptide in the vitamin K-dependent proteins
Q37393881Molecular basis of hemophilia B: a defective enzyme due to an unprocessed propeptide is caused by a point mutation in the factor IX precursor
Q24632512Molecular cloning of matrix Gla protein: implications for substrate recognition by the vitamin K-dependent gamma-carboxylase
Q42858479No evidence for vitamin K-dependent carboxylation of canine surfactant apoproteins, 28-36 kDa
Q41643108Nucleotide sequence of prothrombin gene in abnormal prothrombin-producing hepatocellular carcinoma cell lines
Q22254871Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation
Q31664403On a potential global role for vitamin K-dependent gamma-carboxylation in animal systems. Evidence for a gamma-glutamyl carboxylase in Drosophila
Q38494725Osteogenic activity of bone marrow-derived mesenchymal stem cells (BMSCs) seeded on irradiated allogenic bone
Q28271279Processive post-translational modification. Vitamin K-dependent carboxylation of a peptide substrate
Q47708314Proprotein convertase furin regulates osteocalcin and bone endocrine function
Q37100463Purification and identification of bovine liver gamma-carboxylase
Q39761459Recent advances in hepatic vitamin K metabolism and function
Q44625034Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats.
Q28086880Structural and functional insights into enzymes of the vitamin K cycle
Q73674227The active site region of the vitamin K-dependent carboxylase includes both the amino-terminal hydrophobic and carboxy-terminal hydrophilic domains of the protein
Q40515691The cDNA and derived amino acid sequences of human and bovine bone Gla protein
Q34322156The first gamma-carboxyglutamic acid-containing contryphan. A selective L-type calcium ion channel blocker isolated from the venom of Conus marmoreus
Q52527775The gamma-carboxylation recognition site is sufficient to direct vitamin K-dependent carboxylation on an adjacent glutamate-rich region of thrombin in a propeptide-thrombin chimera.
Q73257800The propeptide binding site of the bovine gamma-glutamyl carboxylase
Q40391746The propeptide region of clotting factor IX is a signal for a vitamin K dependent carboxylase: evidence from protein engineering of amino acid -4.
Q77841219The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase
Q74190477The putative vitamin K-dependent gamma-glutamyl carboxylase internal propeptide appears to be the propeptide binding site
Q28274345The vitamin K cycle
Q34591421Vitamin K-dependent carboxylase: possible role of the substrate "propeptide" as an intracellular recognition site
Q35738080Vitamin K-dependent carboxylation of the carboxylase
Q28274366Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification
Q28276544cDNA and Gene Structure for a Human Subtilisin-Like Protease with Cleavage Specificity for Paired Basic Amino Acid Residues
Q33251549cDNA and deduced amino acid sequence of mouse matrix gla protein: One of five glutamic acid residues potentially modified to gla is not conserved in the mouse sequence
Q33893219trans-10,cis-12 CLA promotes osteoblastogenesis via SMAD mediated mechanism in bone marrow mesenchymal stem cells
Q36351185trans-10,cis-12 conjugated linoleic acid promotes bone formation by inhibiting adipogenesis by peroxisome proliferator activated receptor-γ-dependent mechanisms and by directly enhancing osteoblastogenesis from bone marrow mesenchymal stem cells

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