Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides

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Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1039/C5MD00351B
P932PMC publication ID4723106
P698PubMed publication ID26811741

P50authorJonathan R. ChekanQ56994422
P2093author name stringSatish K Nair
Dillon P Cogan
P2860cites workRapid vacuolar sequestration: the horseweed glyphosate resistance mechanismQ24611203
InterPro in 2011: new developments in the family and domain prediction databaseQ24620144
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detailQ24628981
Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparumQ24653974
Molecular basis for the herbicide resistance of Roundup Ready cropsQ24678302
How the mutation glycine96 to alanine confers glyphosate insensitivity to 5-enolpyruvyl shikimate-3-phosphate synthase from Escherichia coliQ27639960
Structure and mechanism of the glycerol-3-phosphate transporter from Escherichia coliQ27641769
A new view of the mechanisms of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) and 5-enolpyruvylshikimate-3-phosphate synthase (AroA) derived from X-ray structures of their tetrahedral reaction intermediate statesQ27642065
Structure of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a quaternary complex with a magnesium ion, NADPH and the antimalarial drug fosmidomycinQ27645328
Structure and mechanism of the genomically encoded fosfomycin resistance protein, FosX, from Listeria monocytogenesQ27645727
Structural Basis of Glyphosate Resistance Resulting from the Double Mutation Thr97 -> Ile and Pro101 -> Ser in 5-Enolpyruvylshikimate-3-phosphate Synthase from Escherichia coliQ27653747
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasitesQ27684806
Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycinQ27734363
Site-directed mutagenesis of a conserved region of the 5-enolpyruvylshikimate-3-phosphate synthase active siteQ56904397
Functional Genomics Analysis of Horseweed (Conyza canadensis) with Special Reference to the Evolution of Non–Target-Site Glyphosate ResistanceQ57052693
Detection and characterization of a phospholactoyl-enzyme adduct in the reaction catalyzed by UDP-N-acetylglucosamine enolpyruvoyl transferase, MurZQ72160243
Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycinQ72160246
Phosphonomycin, a New Antibiotic Produced by Strains of StreptomycesQ72475705
Phosphonomycin: structure and synthesisQ72531472
The Site of the Inhibition of the Shikimate Pathway by Glyphosate: II. INTERFERENCE OF GLYPHOSATE WITH CHORISMATE FORMATION IN VIVO AND IN VITROQ83254956
Growth inhibition of Mycobacterium smegmatis by prodrugs of deoxyxylulose phosphate reducto-isomerase inhibitors, promising anti-mycobacterial agentsQ83616690
Transition state analysis of acid-catalyzed hydrolysis of an enol ether, enolpyruvylshikimate 3-phosphate (EPSP)Q84526528
Evolution of a double amino acid substitution in the 5-enolpyruvylshikimate-3-phosphate synthase in Eleusine indica conferring high-level glyphosate resistanceQ86832731
Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)Q95423351
The Site of the Inhibition of the Shikimate Pathway by Glyphosate: I. INHIBITION BY GLYPHOSATE OF PHENYLPROPANOID SYNTHESIS IN BUCKWHEAT (FAGOPYRUM ESCULENTUM MOENCH)Q95449569
The shikimate pathway and aromatic amino Acid biosynthesis in plantsQ28265882
Phenylpropanoid biosynthesisQ28268774
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilisQ28359895
Lipophilic prodrugs of FR900098 are antimicrobial against Francisella novicida in vivo and in vitro and show GlpT independent efficacyQ28484402
1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycinQ28486452
Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptakeQ33335973
Gene amplification confers glyphosate resistance in Amaranthus palmeri.Q33666914
Interaction of fosfomycin with the glycerol 3-phosphate transporter of Escherichia coliQ34203685
The mechanism of action of fosfomycin (phosphonomycin)Q34214482
The herbicide glyphosate is a potent inhibitor of 5-enolpyruvyl-shikimic acid-3-phosphate synthaseQ34286370
Glyphosate resistance: state of knowledgeQ34659035
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogsQ35546983
Resistance to the antimicrobial agent fosmidomycin and an FR900098 prodrug through mutations in the deoxyxylulose phosphate reductoisomerase gene (dxr).Q35678194
Biological costs and mechanisms of fosfomycin resistance in Escherichia coliQ35685710
Resistance of Francisella novicida to fosmidomycin associated with mutations in the glycerol-3-phosphate transporterQ36159482
Transport of antibiotics and metabolite analogs by systems under cyclic AMP control: positive selection of Salmonella typhimurium cya and crp mutantsQ36417093
Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterizationQ36628727
Isolation and Characterization of a Phosphonomycin-Resistant Mutant of Escherichia coli K-12Q36776831
Evidence that the fosfomycin target Cys115 in UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is essential for product releaseQ37866109
Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens.Q37957839
E. coli MEP synthase: steady-state kinetic analysis and substrate bindingQ38293440
Trends in pesticide use on soybean, corn and cotton since the introduction of major genetically modified crops in the United StatesQ38982779
Formation of an adduct between fosfomycin and glutathione: a new mechanism of antibiotic resistance in bacteriaQ39832506
Tn292l, a transposon encoding fosfomycin resistanceQ39984364
Characterization of the horseweed (Conyza canadensis) transcriptome using GS-FLX 454 pyrosequencing and its application for expression analysis of candidate non-target herbicide resistance genesQ42935500
A secondary kinetic isotope effect study of the 1-deoxy-D-xylulose-5-phosphate reductoisomerase-catalyzed reaction: evidence for a retroaldol-aldol rearrangementQ43170082
Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coliQ43195414
Glyphosate-resistant goosegrass. Identification of a mutation in the target enzyme 5-enolpyruvylshikimate-3-phosphate synthaseQ44062043
Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants ofEscherichia coliQ44603208
The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformationQ45164979
YbiV from Escherichia coli K12 is a HAD phosphataseQ45229449
Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosaQ45291346
Catalytic residues and an electrostatic sandwich that promote enolpyruvyl shikimate 3-phosphate synthase (AroA) catalysisQ46094902
Alteration of a single amino acid residue reverses fosfomycin resistance of recombinant MurA from Mycobacterium tuberculosisQ47904411
Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre surveyQ48044137
Genome-wide analysis of substrate specificities of the Escherichia coli haloacid dehalogenase-like phosphatase familyQ48698153
An Altered aroA Gene Product Confers Resistance to the Herbicide GlyphosateQ50211083
Glyphosate, paraquat and ACCase multiple herbicide resistance evolved in a Lolium rigidum biotype.Q50787112
Substitution of Gly-96 to Ala in the 5-enolpyruvylshikimate-3-phosphate synthase of Klebsiella pneumoniae results in a greatly reduced affinity for the herbicide glyphosate.Q54312429
In vitro and in vivo antibacterial activities of FR-31564, a new phosphonic acid antibiotic.Q54560458
Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin.Q54590227
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectherbicide resistanceQ23470985
P304page(s)28-36
P577publication date2015-10-12
P1433published inMedChemCommQ3303881
P1476titleMolecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides
P478volume7

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cites work (P2860)
Q37650512Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads.
Q90293831Production of β-Lactamase Inhibitors by Streptomyces Species

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