Adaptive immunity in atherogenesis: new insights and therapeutic approaches

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Adaptive immunity in atherogenesis: new insights and therapeutic approaches is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1172/JCI63108
P932PMC publication ID3533280
P698PubMed publication ID23281407

P50authorChristoph J BinderQ54148886
Joseph L WitztumQ62567829
Sotirios TsimikasQ80167861
P2093author name stringAndrew H Lichtman
P2860cites workHuman B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-Q24594899
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B-cell aortic homing and atheroprotection depend on Id3.Q30422974
Dynamic T cell-APC interactions sustain chronic inflammation in atherosclerosisQ30425368
Circulating autoantibodies to oxidized LDL correlate with arterial accumulation and depletion of oxidized LDL in LDL receptor-deficient miceQ31807203
Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesionsQ33294845
Innate and adaptive immunity in atherosclerosisQ33659705
CD8+ T cell activation predominate early immune responses to hypercholesterolemia in Apoe⁻(/)⁻ miceQ33761718
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responsesQ33819043
Low density lipoprotein undergoes oxidative modification in vivoQ33838672
Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosisQ33839918
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FcgammaRIIB inhibits the development of atherosclerosis in low-density lipoprotein receptor-deficient mice.Q43185229
Resident intimal dendritic cells accumulate lipid and contribute to the initiation of atherosclerosis.Q43247649
Inhibition of IL-17A attenuates atherosclerotic lesion development in apoE-deficient miceQ43455128
Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient miceQ43633700
Oxidized low-density lipoprotein and atherosclerosisQ43816762
Interleukin-4 deficiency decreases atherosclerotic lesion formation in a site-specific manner in female LDL receptor-/- miceQ43909351
Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient miceQ44149442
B-lymphocyte deficiency increases atherosclerosis in LDL receptor-null miceQ44212443
Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouseQ44342113
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Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.Q46095021
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.Q46326610
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High levels of costimulatory receptors OX40 and 4-1BB characterize CD4+CD28null T cells in patients with acute coronary syndrome.Q53189579
CD137 (4-1BB) deficiency reduces atherosclerosis in hyperlipidemic mice.Q53340266
Induction of oral tolerance to HSP60 or an HSP60-peptide activates T cell regulation and reduces atherosclerosis.Q53524929
Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice.Q53591262
Induction of oral tolerance to oxidized low-density lipoprotein ameliorates atherosclerosis.Q53591922
Expression of circulatory dendritic cells and regulatory T-cells in patients with different subsets of coronary artery diseaseQ39597084
Human oxidation-specific antibodies reduce foam cell formation and atherosclerosis progressionQ39601696
Hypercholesterolemia is associated with a T helper (Th) 1/Th2 switch of the autoimmune response in atherosclerotic apo E-knockout miceQ39802780
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Interleukin-18 enhances atherosclerosis in apolipoprotein E(-/-) mice through release of interferon-gammaQ42162162
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Exogenous interferon-gamma enhances atherosclerosis in apolipoprotein E-/- miceQ42757050
A Critical Function of Th17 Proinflammatory Cells in the Development of Atherosclerotic Plaque in MiceQ42856694
CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosisQ43145952
Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule.Q53591929
Activation of Th17/Th1 and Th1, but not Th17, is associated with the acute cardiac event in patients with acute coronary syndrome.Q54375886
Conventional B2 B cell depletion ameliorates whereas its adoptive transfer aggravates atherosclerosis.Q54412663
Differential expression of interleukin-17 family cytokines in intact and complicated human atherosclerotic plaques.Q54449577
Fcgamma receptor deficiency confers protection against atherosclerosis in apolipoprotein E knockout mice.Q54463267
Interleukin 17: An unlikely marker of acute coronary syndrome?Q57515022
Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote AtherosclerosisQ57574579
Regulatory T-Cell Response to Apolipoprotein B100–Derived Peptides Reduces the Development and Progression of Atherosclerosis in MiceQ58148629
Natural regulatory T cells control the development of atherosclerosis in miceQ58149268
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Brodalumab, an Anti–Interleukin-17–Receptor Antibody for PsoriasisQ58992083
Interleukin-17A Deficiency Accelerates Unstable Atherosclerotic Plaque Formation in Apolipoprotein E-Deficient MiceQ62735590
Atherosclerotic lesions in humans. In situ immunophenotypic analysis suggesting an immune mediated responseQ69742103
Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaqueQ69990504
Transfer of CD4(+) T cells aggravates atherosclerosis in immunodeficient apolipoprotein E knockout miceQ73288555
Costimulatory molecules in human atherosclerotic plaques: an indication of antigen specific T lymphocyte activationQ73701453
Role of interleukin-17 and interleukin-17-induced cytokines interleukin-6 and interleukin-8 in unstable coronary artery diseaseQ79374759
CD137 is expressed in human atherosclerosis and promotes development of plaque inflammation in hypercholesterolemic miceQ80733397
The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cellsQ81161461
A functional role for inducible costimulator (ICOS) in atherosclerosisQ81822869
Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to the pathogenesis of atherosclerosisQ82102394
Increased Th17 cells in coronary artery disease are associated with neutrophilic inflammationQ83176229
Effect of oral atorvastatin on CD4+CD25+ regulatory T cells, FoxP3 expression, and prognosis in patients with ST-segment elevated myocardial infarction before primary percutaneous coronary interventionQ83378943
Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic miceQ83491273
Targeting T cell costimulation to prevent atherothrombosisQ83683620
To be 17 again--anti-interleukin-17 treatment for psoriasisQ83759147
Counterregulation rules in atherothrombosisQ83874223
CD4+LAP + and CD4 +CD25 +Foxp3 + regulatory T cells induced by nasal oxidized low-density lipoprotein suppress effector T cells response and attenuate atherosclerosis in ApoE-/- miceQ84061197
Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wallQ85054596
Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)Q85063666
Interleukin-17 and interferon-gamma are produced concomitantly by human coronary artery-infiltrating T cells and act synergistically on vascular smooth muscle cellsQ33967700
B cell depletion reduces the development of atherosclerosis in miceQ34044387
Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in miceQ34082315
Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammationQ34125054
The immune system in atherosclerosisQ34164644
Re-evaluation of the risk for major adverse cardiovascular events in patients treated with anti-IL-12/23 biological agents for chronic plaque psoriasis: a meta-analysis of randomized controlled trialsQ34189897
TAP1-deficiency does not alter atherosclerosis development in Apoe-/- miceQ34221791
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoproteinQ34390132
Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice.Q34582934
Contributions of PD-1/PD-L1 pathway to interactions of myeloid DCs with T cells in atherosclerosisQ34601335
The inhibitory FcγRIIb modulates the inflammatory response and influences atherosclerosis in male apoE(-/-) miceQ34644753
Oxidized phospholipids, lipoprotein(a), lipoprotein-associated phospholipase A2 activity, and 10-year cardiovascular outcomes: prospective results from the Bruneck studyQ34654209
Defective leptin/leptin receptor signaling improves regulatory T cell immune response and protects mice from atherosclerosisQ34661745
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cellsQ34709777
Immunization of low density lipoprotein (LDL) receptor-deficient rabbits with homologous malondialdehyde-modified LDL reduces atherogenesisQ34737721
Protective immunity against atherosclerosis carried by B cells of hypercholesterolemic miceQ34789613
Innate and acquired immunity in atherogenesisQ34986341
Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammationQ35013382
Role of interleukin 17 in inflammation, atherosclerosis, and vascular function in apolipoprotein e-deficient miceQ35050827
Deleting TCR alpha beta+ or CD4+ T lymphocytes leads to opposite effects on site-specific atherosclerosis in female apolipoprotein E-deficient miceQ35103567
Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemiaQ35133174
Psoriasis and vascular disease-risk factors and outcomes: a systematic review of the literatureQ35168945
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- miceQ35187080
Antigen presentation to naive CD4 T cells in the lymph node.Q35187925
Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk StudyQ35212898
Attenuated atherosclerotic lesions in apoE-Fcγ-chain-deficient hyperlipidemic mouse model is associated with inhibition of Th17 cells and promotion of regulatory T cellsQ35566640
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in miceQ35572404
Oxidized phospholipids on apoB-100-containing lipoproteins: a biomarker predicting cardiovascular disease and cardiovascular eventsQ35592510
Cancer immunotherapy comes of ageQ35666338
Autoimmune and inflammatory mechanisms in atherosclerosisQ35698466
The role of interleukin-4 and interleukin-12 in the progression of atherosclerosis in apolipoprotein E-deficient miceQ35792034
Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.Q35833004
In vivo detection of oxidation-specific epitopes in atherosclerotic lesions using biocompatible manganese molecular magnetic imaging probesQ35905632
The IL-17A/IL-17RA axis plays a proatherogenic role via the regulation of aortic myeloid cell recruitmentQ35915712
Statins induce the accumulation of regulatory T cells in atherosclerotic plaqueQ36071708
Lymphocytes are important in early atherosclerosisQ36072647
Mechanisms of suppression by suppressor T cellsQ36078047
T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouseQ36142970
Interleukin-4 does not influence development of hypercholesterolemia or angiotensin II-induced atherosclerotic lesions in miceQ36202916
How dendritic cells shape atherosclerosisQ36235238
Human "orchestrator" CD11b(+) B1 cells spontaneously secrete interleukin-10 and regulate T-cell activityQ36283440
Interleukin-13 protects from atherosclerosis and modulates plaque composition by skewing the macrophage phenotypeQ36379539
Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritisQ36399030
Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatoryQ36399652
IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosisQ36849075
Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell responseQ36903682
Antibodies to oxidized low density lipoprotein: epidemiological studies and potential clinical applications in cardiovascular disease.Q37037196
The role of adaptive T cell immunity in atherosclerosisQ37339539
IFN-gamma potentiates atherosclerosis in ApoE knock-out miceQ37368296
The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/- miceQ37372718
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosisQ37377439
Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient miceQ37385727
Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10.Q37467868
Vaccination against atherosclerosis? Induction of atheroprotective immunityQ37495603
Interleukin-17: friend or foe in atherosclerosis?Q37777607
Cardiovascular disease in rheumatoid arthritis: state of the art and future perspectivesQ37812524
Complement in atherosclerosis: friend or foe?Q37820714
Oxidation-specific epitopes are danger-associated molecular patterns recognized by pattern recognition receptors of innate immunityQ37830940
The infectious burden in atherothrombosisQ37848724
IL-17A Is Proatherogenic in High-Fat Diet-Induced and Chlamydia pneumoniae Infection-Accelerated Atherosclerosis in MiceQ37852203
Mechanisms for the anti-inflammatory effects of statinsQ37853818
Recent advances on the role of cytokines in atherosclerosisQ37867358
Deciphering the role of Th17 cells in human diseaseQ37940695
Atherosclerosis: current pathogenesis and therapeutic optionsQ37953777
A killer on the road: circulating CD4(+)CD28null T cells as cardiovascular risk factor in ESRD patients.Q37963812
Immune regulatory function of B cells.Q37973774
Phenotypic and functional heterogeneity of macrophages and dendritic cell subsets in the healthy and atherosclerosis-prone aortaQ37998021
Inhibition of interleukin-5 for the treatment of eosinophilic diseases.Q38006131
Apolipoprotein B100 autoimmunity and atherosclerosis - disease mechanisms and therapeutic potentialQ38027749
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P433issue1
P407language of work or nameEnglishQ1860
P304page(s)27-36
P577publication date2013-01-02
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleAdaptive immunity in atherogenesis: new insights and therapeutic approaches
P478volume123