Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis

scholarly article

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2008PNAS..105.2427S
P356DOI10.1073/PNAS.0711324105
P932PMC publication ID2268153
P698PubMed publication ID18250332
P5875ResearchGate publication ID5602714

P50authorUlf LandegrenQ5933554
Ola SöderbergQ39977684
P2093author name stringHumbert De Smedt
Farid Khan
Jan B Parys
Veerle Vanderheyden
Eric Chastre
Larissa Kotelevets
H Llewelyn Roderick
Martin D Bootman
Katja Rietdorf
Tania Szado
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Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1Q24310249
PTEN function: how normal cells control it and tumour cells lose itQ24528114
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteinsQ24535901
AKT/PKB signaling: navigating downstreamQ24657857
Signaling through scaffold, anchoring, and adaptor proteinsQ28131792
The versatility and universality of calcium signallingQ29547402
Regulation of cell death: the calcium-apoptosis linkQ29615554
Direct observation of individual endogenous protein complexes in situ by proximity ligationQ29616032
Dynamics of three-dimensional replication patterns during the S-phase, analysed by double labelling of DNA and confocal microscopyQ31042736
Cytochrome c binds to inositol (1,4,5) trisphosphate receptors, amplifying calcium-dependent apoptosisQ34275661
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathwayQ34278037
Modulation of Ca2+ oscillations by phosphorylation of Ins(1,4,5)P3 receptorsQ35541365
Targeting the PI3K-Akt pathway in human cancer: rationale and promiseQ35571372
Flirting in little space: the ER/mitochondria Ca2+ liaisonQ35628367
Structure, regulation and function of PKB/AKT--a major therapeutic targetQ35692051
Inositol 1,4,5-trisphosphate receptors as signal integratorsQ35799975
Putting the rap on Akt.Q35917901
Cell signalling: IP3 receptors channel calcium into cell death.Q35941546
Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.Q36119444
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.Q36322335
The lipid phosphatase activity of PTEN is critical for stabilizing intercellular junctions and reverting invasivenessQ36381379
The inositol 1,4,5-trisphosphate receptor (IP3R) and its regulators: sometimes good and sometimes bad teamworkQ36667403
Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylationQ39551585
Localization of agonist-sensitive PtdIns(3,4,5)P3 reveals a nuclear pool that is insensitive to PTEN expression.Q40198370
ATP binding to a unique site in the type-1 S2- inositol 1,4,5-trisphosphate receptor defines susceptibility to phosphorylation by protein kinase A.Q40290784
Akt kinase phosphorylation of inositol 1,4,5-trisphosphate receptorsQ40342833
The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3RQ40369800
Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domainsQ40575943
B cell antigen receptor-induced activation of Akt promotes B cell survival and is dependent on Syk kinaseQ40867426
Type I, II, and III inositol 1,4,5-trisphosphate receptors are unequally susceptible to down-regulation and are expressed in markedly different proportions in different cell typesQ41345900
Apoptosis driven by IP(3)-linked mitochondrial calcium signalsQ42265765
Mitochondrial Ca(2+) uptake depends on the spatial and temporal profile of cytosolic Ca(2+) signalsQ42503733
Menadione-induced apoptosis: roles of cytosolic Ca(2+) elevations and the mitochondrial permeability transition poreQ43893432
Cardiac type 2 inositol 1,4,5-trisphosphate receptor: interaction and modulation by calcium/calmodulin-dependent protein kinase II.Q45264881
Functional properties of recombinant type I and type III inositol 1, 4,5-trisphosphate receptor isoforms expressed in COS-7 cellsQ73675895
The role of the S4-S5 linker and C-terminal tail in inositol 1,4,5-trisphosphate receptor functionQ79827720
P4510describes a project that usesImageJQ1659584
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
apoptotic processQ14599311
P304page(s)2427-2432
P577publication date2008-02-04
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePhosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis
P478volume105

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