| scholarly article | Q13442814 |
| P2093 | author name string | Thomas P Burris | |
| Douglas J Kojetin | |||
| P2860 | cites work | Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways | Q24300630 |
| Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists | Q24629345 | ||
| Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA | Q24655111 | ||
| Identification of heme as the ligand for the orphan nuclear receptors REV-ERBalpha and REV-ERBbeta | Q24655134 | ||
| Structure of the ligand-binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist | Q27619550 | ||
| Structural basis for autorepression of retinoid X receptor by tetramer formation and the AF-2 helix | Q27626893 | ||
| Structural insights into the mode of action of a pure antiestrogen | Q27630646 | ||
| Structure of the PPARalpha and -gamma ligand binding domain in complex with AZ 242; ligand selectivity and agonist activation in the PPAR family | Q27635210 | ||
| Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism | Q27638851 | ||
| Partial agonists activate PPARgamma using a helix 12 independent mechanism | Q27648786 | ||
| NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses | Q27650089 | ||
| Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method | Q27650591 | ||
| INT131: a selective modulator of PPAR gamma | Q27655522 | ||
| Coupling of receptor conformation and ligand orientation determine graded activity | Q27664921 | ||
| Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors | Q27675297 | ||
| Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha | Q27730245 | ||
| Molecular basis of agonism and antagonism in the oestrogen receptor | Q27746278 | ||
| Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma | Q27765353 | ||
| Crystal structure of the ligand binding domain of the human nuclear receptor PPARgamma | Q27766012 | ||
| The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen | Q27766417 | ||
| Molecular determinants for the tissue specificity of SERMs | Q28211516 | ||
| Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription | Q29547846 | ||
| Investigation of ligand interactions with human RXRalpha by hydrogen/deuterium exchange and mass spectrometry. | Q30355962 | ||
| Hydrogen/Deuterium Exchange Reveals Distinct Agonist/Partial Agonist Receptor Dynamics within Vitamin D Receptor/Retinoid X Receptor Heterodimer | Q30497045 | ||
| Protein analysis by hydrogen exchange mass spectrometry | Q30888751 | ||
| Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data | Q33884396 | ||
| Structural aspects of agonism and antagonism in the oestrogen receptor | Q34016135 | ||
| A structural biologist's view of the oestrogen receptor. | Q34132640 | ||
| Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. | Q34330155 | ||
| Helix 11 dynamics is critical for constitutive androstane receptor activity. | Q34548544 | ||
| DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex | Q34927801 | ||
| Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand | Q35143424 | ||
| Agonist-bound nuclear receptors: not just targets of coactivators. | Q35197683 | ||
| Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation | Q35230678 | ||
| Estrogen signaling: a subtle balance between ER alpha and ER beta | Q35679583 | ||
| The coactivator LXXLL nuclear receptor recognition motif. | Q35721024 | ||
| Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. | Q35753031 | ||
| Mechanism of the nuclear receptor molecular switch | Q35846738 | ||
| Identification of SR2211: a potent synthetic RORγ-selective modulator. | Q35903192 | ||
| Lessons learnt from structural studies of the oestrogen receptor | Q36415964 | ||
| Conformational changes of the glucocorticoid receptor ligand binding domain induced by ligand and cofactor binding, and the location of cofactor binding sites determined by hydrogen/deuterium exchange mass spectrometry | Q36458264 | ||
| Estrogen receptor beta: an overview and update | Q36478020 | ||
| Implications of the binding of tamoxifen to the coactivator recognition site of the estrogen receptor | Q37255669 | ||
| Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange. | Q37435225 | ||
| Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry | Q38485202 | ||
| T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities | Q40747044 | ||
| Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators | Q42237982 | ||
| Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator | Q42805803 | ||
| Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRalpha LBD. | Q42970996 | ||
| Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662. | Q44001857 | ||
| Dynamics and ligand-induced solvent accessibility changes in human retinoid X receptor homodimer determined by hydrogen deuterium exchange and mass spectrometry | Q44742625 | ||
| Analysis of ligand binding and protein dynamics of human retinoid X receptor alpha ligand-binding domain by nuclear magnetic resonance | Q46929334 | ||
| A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease. | Q53944127 | ||
| Ligand-induced stabilization of PPARgamma monitored by NMR spectroscopy: implications for nuclear receptor activation | Q73675477 | ||
| Molecular sensors of estrogen receptor conformations and dynamics | Q73881408 | ||
| P433 | issue | 1 | |
| P921 | main subject | drug discovery | Q1418791 |
| P304 | page(s) | 1-8 | |
| P577 | publication date | 2012-08-06 | |
| P1433 | published in | Molecular Pharmacology | Q1943386 |
| P1476 | title | Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery | |
| P478 | volume | 83 |
| Q38829472 | 14-3-3 Isoforms Differentially Regulate NFκB Signaling in the Brain After Ischemia-Reperfusion |
| Q89790880 | A molecular switch regulating transcriptional repression and activation of PPARγ |
| Q58586525 | A structural mechanism for directing corepressor-selective inverse agonism of PPARγ |
| Q40993997 | Activation helix orientation of the estrogen receptor is mediated by receptor dimerization: evidence from molecular dynamics simulations. |
| Q33799630 | An alternative conformation of ERβ bound to estradiol reveals H12 in a stable antagonist position |
| Q55379909 | Defining a conformational ensemble that directs activation of PPARγ. |
| Q36493995 | Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor |
| Q37303615 | Discovery of Isoquinolinoquinazolinones as a Novel Class of Potent PPARγ Antagonists with Anti-adipogenic Effects |
| Q91971698 | Extra-Adrenal Glucocorticoid Synthesis in the Intestinal Mucosa: Between Immune Homeostasis and Immune Escape |
| Q36733126 | In vitro Screening and Evaluation of 37 Traditional Chinese Medicines for Their Potential to Activate Peroxisome Proliferator-Activated Receptors-γ. |
| Q47927975 | Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold |
| Q52688314 | Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion. |
| Q57289952 | Protein Conformational Transitions from All-Atom Adaptively Biased Path Optimization |
| Q90702022 | Quantitative structural assessment of graded receptor agonism |
| Q93382475 | State-of-the-art: functional fluorescent probes for bioimaging and pharmacological research |
| Q38843487 | Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner |
| Q91122065 | Structural Insights into the Ligand Binding Domain of the Glucocorticoid Receptor: A Molecular Dynamics Study |
| Q35990304 | Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. |
| Q27012669 | Targeting xenobiotic receptors PXR and CAR in human diseases |
| Q41587565 | The conformational dynamics of H2-H3n and S2-H6 in gating ligand entry into the buried binding cavity of vitamin D receptor |
| Q57169333 | The nuclear receptor superfamily: A structural perspective |
| Q28538838 | Towards structural systems pharmacology to study complex diseases and personalized medicine |
| Q36466200 | Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity. |
| Q38972663 | Visualizing the Architectures and Interactions of Nuclear Receptors |
| Q47684449 | Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort |
Search more.