The influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis

scientific article published on 19 November 2015

The influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/ETM.2015.2884
P932PMC publication ID4726872
P698PubMed publication ID26889229
P5875ResearchGate publication ID284195734

P50authorJingping YangQ84002530
Xiyuan XuQ86978383
P2093author name stringJianping Zhang
Yun Su
Lihong Zhang
Guohua Liu
Haixia Sun
Liangshen Liang
P2860cites workTLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
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Sepsis, severe sepsis and septic shock: changes in incidence, pathogens and outcomesQ22305929
TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humansQ24678506
Host innate immune responses to sepsisQ26864635
Innate immune recognitionQ27860721
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseaseQ28239710
The evolutionary history of TLR4 polymorphisms in EuropeQ28249601
Toll-like receptors: critical proteins linking innate and acquired immunityQ29615190
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceQ29618757
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosyQ33482057
Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injuryQ33758964
Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohortsQ34026949
Targeting Toll-like receptor (TLR) signaling by Toll/interleukin-1 receptor (TIR) domain-containing adapter protein/MyD88 adapter-like (TIRAP/Mal)-derived decoy peptides.Q34286955
Human cytomegalovirus induces TLR4 signaling components in monocytes altering TIRAP, TRAM and downstream interferon-beta and TNF-alpha expressionQ34412487
Variants in the Toll-interacting protein gene are associated with susceptibility to sepsis in the Chinese Han populationQ35567176
Genetic analysis of QTL for eye cross and eye diameter in common carp (Cyprinus carpio L.) using microsatellites and SNPsQ35628157
Role of chemokines in the pathogenesis of acute lung injuryQ35991282
Scoring Systems in Assessing Survival of Critically Ill ICU PatientsQ36036570
Role of polymorphisms of toll-like receptor (TLR) 4, TLR9, toll-interleukin 1 receptor domain containing adaptor protein (TIRAP) and FCGR2A genes in malaria susceptibility and severity in Burundian childrenQ36138620
Genomic variations and susceptibility to sepsisQ36647725
Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN miceQ37043190
Role of Toll-like receptors in the development of sepsisQ37085653
Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shockQ37238784
Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues.Q37978390
Sepsis and septic shockQ38126580
Reducing sepsis mortalityQ38202653
A gene encoding a novel multidomain beta-1,4-mannanase from Caldibacillus cellulovorans and action of the recombinant enzyme on kraft pulpQ39485020
Transgenic zebrafish reporter lines reveal conserved Toll-like receptor signaling potential in embryonic myeloid leukocytes and adult immune cell lineagesQ47617823
Functional interaction between SNPs and microsatellite in the transcriptional regulation of insulin-like growth factor 1.Q50916816
Toll-like receptor pathway signaling is differently regulated in neutrophils and peripheral mononuclear cells of patients with sepsis, severe sepsis, and septic shock.Q53434347
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population.Q54284814
Toll-like receptor 4 gene C119A but not Asp299Gly polymorphism is associated with ischemic stroke among ethnic Chinese in Taiwan.Q54662527
Simple genotype analysis of the Asp299Gly polymorphism of the Toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsivenessQ77615220
Actin filament reorganization is a key step in lung inflammation induced by systemic inflammatory response syndromeQ84431247
Genetic polymorphisms in sepsisQ84854690
P433issue1
P921main subjectsepsisQ183134
toll-like receptorQ408004
P304page(s)131-139
P577publication date2015-11-19
P1433published inExperimental and Therapeutic MedicineQ23979083
P1476titleThe influence of genetic polymorphisms in TLR4 and TIRAP, and their expression levels in peripheral blood, on susceptibility to sepsis
P478volume11