Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene

scientific article published on January 2003

Design of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.3748/WJG.V9.I1.104
P932PMC publication ID4728220
P698PubMed publication ID12508361
P5875ResearchGate publication ID291571379

P2093author name stringJin-Yan Luo
Zhi-Ming Hao
Jin Cheng
Guang-Xiao Yang
Quan-Yin Wang
P2860cites workRibozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomeraseQ40812288
Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cellsQ40912325
Supression of telomerase activity in HL60 cells after treatment with differentiating agents.Q41181910
Telomere, telomerase and digestive cancerQ41514614
Telomerase activity in gastric cancer and its clinical implicationsQ41514806
Antisense telomerase RNA induced human gastric cancer cell apoptosis.Q43119002
Simple RNA enzymes with new and highly specific endoribonuclease activitiesQ43501578
Telomerase activity reconstituted in vitro with purified human telomerase reverse transcriptase and human telomerase RNA componentQ52579047
Telomere end-replication problem and cell agingQ56508218
The 5'-end of hTERT mRNA is a good target for hammerhead ribozyme to suppress telomerase activityQ73938445
Attenuation of telomerase activity by a hammerhead ribozyme targeting the template region of telomerase RNA in endometrial carcinoma cellsQ77670060
Extension of life-span by introduction of telomerase into normal human cellsQ24336088
Secondary structure prediction and in vitro accessibility of mRNA as tools in the selection of target sites for ribozymesQ24527367
Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structureQ27860806
The RNA component of human telomeraseQ28288330
Telomerase Catalytic Subunit Homologs from Fission Yeast and HumanQ29615387
Specific regulation of gene expression by antisense, sense and antigene nucleic acidsQ33256068
Telomeres, telomerase and cancer: an up-dateQ34017173
Suppression of gene expression by targeted disruption of messenger RNA: available options and current strategies.Q34047091
A kinetic and thermodynamic framework for the hammerhead ribozyme reactionQ34337820
Effects of variations in length of hammerhead ribozyme antisense arms upon the cleavage of longer RNA substratesQ34624225
The effect of structure in a long target RNA on ribozyme cleavage efficiencyQ34646173
Activation of telomerase in a human tumorQ35141128
Telomere and telomerase in the initial stage of immortalization of esophageal epithelial cell.Q36316137
Characterization of human telomerase complex.Q36581467
Telomere loss: mitotic clock or genetic time bomb?Q36706939
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell deathQ36742412
Chromosome first aid.Q37430022
Expression of mouse telomerase catalytic subunit in embryos and adult tissues.Q37470406
Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always betterQ37571777
RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extractsQ38311071
The subcellular localization and length of hammerhead ribozymes determine efficacy in human cellsQ39719115
Sequence specificity of the hammerhead ribozyme revisited; the NHH ruleQ39724988
Recent developments in the hammerhead ribozyme fieldQ39725912
A theoretical approach to select effective antisense oligodeoxyribonucleotides at high statistical probabilityQ39729504
A three-nucleotide helix I is sufficient for full activity of a hammerhead ribozyme: advantages of an asymmetric designQ40401413
Telomeres, Telomerase, and ImmortalityQ40477597
Ribozymes as human therapeutic agentsQ40546203
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectribozymeQ205858
P304page(s)104-107
P577publication date2003-01-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleDesign of a ribozyme targeting human telomerase reverse transcriptase and cloning of it's gene
P478volume9

Reverse relations

cites work (P2860)
Q40625583Antiproliferative effect of octreotide on gastric cancer cells mediated by inhibition of Akt/PKB and telomerase
Q33973729Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma
Q34832716Effects of octreotide and insulin on colon cancer cellular proliferation and correlation with hTERT activity
Q40591525Repression of allo-cell transplant rejection through CIITA ribonuclease P+hepatocyte

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