Exploring Staphylococcus aureus pathways to disease for vaccine development.

scientific article published on December 2011

Exploring Staphylococcus aureus pathways to disease for vaccine development. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00281-011-0299-Z
P932PMC publication ID3539746
P698PubMed publication ID22130613

P50authorDominique MissiakasQ96239604
Olaf SchneewindQ64624932
Hwan Keun KimQ82211965
P2093author name stringAndrea DeDent
P2860cites workThe Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3bQ21559500
Structure of the cell wall anchor of surface proteins in Staphylococcus aureusQ22299396
The changing epidemiology of Staphylococcus aureus?Q22305657
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activityQ24290410
Hepcidin, a urinary antimicrobial peptide synthesized in the liverQ24290609
Haptoglobin: a natural bacteriostatQ24302338
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalizationQ24310115
Fibrinogen substrate recognition by staphylocoagulase.(pro)thrombin complexesQ24338455
Novel fluorescent prothrombin analogs as probes of staphylocoagulase-prothrombin interactionsQ24338471
Contribution of coagulases towards Staphylococcus aureus disease and protective immunityQ27313924
Structure of the fibrinogen γ-chain integrin binding and factor XIIIa cross-linking sites obtained through carrier protein driven crystallizationQ27620960
Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activationQ27642265
A Structural Model of the Staphylococcus aureus ClfA–Fibrinogen Interaction Opens New Avenues for the Design of Anti-Staphylococcal TherapeuticsQ27653017
Characterization of staphyloferrin A biosynthetic and transport mutants in Staphylococcus aureusQ27655314
Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitorQ27655786
Three-dimensional structure of the platelet integrin recognition segment of the fibrinogen gamma chain obtained by carrier protein-driven crystallizationQ27729409
Staphylococcus aureus infectionsQ28131787
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overloadQ28139987
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase proteinQ28214986
Direct thrombin inhibitorsQ28271181
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1Q28271523
C3d of complement as a molecular adjuvant: bridging innate and acquired immunityQ28272810
Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3bQ28283397
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout miceQ28586797
Transfer of heme from heme-albumin to hemopexinQ28678488
Molecular characterization of the ferric-uptake regulator, fur, from Staphylococcus aureusQ29346592
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating ironQ29619561
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammationQ29620394
A novel potent vasoconstrictor peptide produced by vascular endothelial cellsQ29620540
Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenasesQ30160416
Staphylococcal vaccines and immunotherapy: to dream the impossible dream?Q30355875
Identification and characterization of a membrane permease involved in iron-hydroxamate transport in Staphylococcus aureusQ30888761
A novel von Willebrand factor binding protein expressed by Staphylococcus aureusQ31095082
Membrane damage elicits an immunomodulatory program in Staphylococcus aureusQ33543122
Complement evasion by human pathogensQ33623972
SirR, a novel iron-dependent repressor in Staphylococcus epidermidisQ33761056
Staphylococcus aureus serotype 5 capsular polysaccharide is antiphagocytic and enhances bacterial virulence in a murine bacteremia modelQ33767412
Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumoniaQ33769082
A fully human monoclonal antibody to Staphylococcus aureus iron regulated surface determinant B (IsdB) with functional activity in vitro and in vivoQ33778077
Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidinQ33818360
Waves of resistance: Staphylococcus aureus in the antibiotic era.Q33854398
A molecular insight into complement evasion by the staphylococcal complement inhibitor protein familyQ33896074
Identification of the haemoglobin scavenger receptor.Q33934404
Sortase-catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureusQ33950921
Immune evasion by staphylococciQ33991798
In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and Is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasisQ33995303
Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with plateletsQ34003911
PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureusQ34007737
An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesisQ34013120
Cross-link in fibrin polymerized by factor 13: epsilon-(gamma-glutamyl)lysineQ34053195
Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood.Q34058113
Characterization of the interaction between the Staphylococcus aureus clumping factor (ClfA) and fibrinogenQ34065001
Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureusQ34067024
Tissue factor on the looseQ34090266
Nontoxigenic protein A vaccine for methicillin-resistant Staphylococcus aureus infections in miceQ34096536
Body iron exchange in man.Q34098726
Role of Iron in Bacterial InfectionQ34182281
Allosteric inhibition of complement function by a staphylococcal immune evasion proteinQ34200056
Specificity of Staphyloferrin B Recognition by the SirA Receptor from Staphylococcus aureusQ34251178
AN ENZYME CASCADE IN THE BLOOD CLOTTING MECHANISM, AND ITS FUNCTION AS A BIOCHEMICAL AMPLIFIER.Q34257237
WATERFALL SEQUENCE FOR INTRINSIC BLOOD CLOTTING.Q34257361
Iron withholding: a defense against infection and neoplasiaQ34259767
White thromboembolism in the hamster cheek pouch after trauma, infection and neoplasiaQ34296162
The crisis in antibiotic resistanceQ34314442
A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetasesQ34395738
What determines nasal carriage of Staphylococcus aureus?Q34453451
A novel Staphylococcus aureus vaccine: iron surface determinant B induces rapid antibody responses in rhesus macaques and specific increased survival in a murine S. aureus sepsis modelQ34492730
Virulence of Staphylococcus aureus in a mouse mastitis model: studies of alpha hemolysin, coagulase, and protein A as possible virulence determinants with protoplast fusion and gene cloningQ37034077
Blood-borne tissue factor: another view of thrombosisQ37181879
Serologic assay to quantify human immunoglobulin G antibodies to the Staphylococcus aureus iron surface determinant B antigenQ37190930
Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombinQ37194661
Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB.Q37256491
Genetic requirements for Staphylococcus aureus abscess formation and persistence in host tissuesQ37355394
Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.Q37388757
Staphylococcus aureus synthesizes adenosine to escape host immune responsesQ37402368
Interferon-gamma in the management of chronic granulomatous disease.Q37557418
Review article: Coagulation cascade and therapeutics update: relevance to nephrology. Part 1: Overview of coagulation, thrombophilias and history of anticoagulants.Q37578743
Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasionQ37697201
Identification of the ligand-binding domain of the surface-located fibrinogen receptor (clumping factor) of Staphylococcus aureusQ38295023
Residues 10-18 within the C5a receptor N terminus compose a binding domain for chemotaxis inhibitory protein of Staphylococcus aureus.Q38334334
The von Willebrand factor-binding protein (vWbp) of Staphylococcus aureus is a coagulaseQ38341380
IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureusQ38348894
Identification and characterization of fhuD1 and fhuD2, two genes involved in iron-hydroxamate uptake in Staphylococcus aureus.Q39504510
Receptor-mediated recognition and uptake of iron from human transferrin by Staphylococcus aureus and Staphylococcus epidermidisQ39572195
Mutational analyses reveal that the staphylococcal immune evasion molecule Sbi and complement receptor 2 (CR2) share overlapping contact residues on C3d: implications for the controversy regarding the CR2/C3d cocrystal structure.Q39750608
Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beadsQ39827332
The role of staphylococcal polysaccharide microcapsule expression in septicemia and septic arthritis.Q39831208
Clumping factor A interaction with complement factor I increases C3b cleavage on the bacterial surface of Staphylococcus aureus and decreases complement-mediated phagocytosisQ39896801
Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophoresQ39954600
The role of coagulase in staphylococcal infectionsQ39961324
Binding of immunoglobulins to protein A and immunoglobulin levels in mammalian seraQ40153929
Studies on staphylococci. II. Effect of coagulase on the virulence of coagulase negative strains.Q40433860
Involvement of SirABC in iron-siderophore import in Staphylococcus aureusQ40535930
Effect of highly purified coagulase and culture filtrate on virulence and immunity of a coagulase-negative mutant of staphylococcus aureus BB.Q40600451
Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B.Q40918234
Plasma and red cell iron turnover in normal subjects and in patients having various hematopoietic disordersQ40979485
The Influence of certain Bacteria on the Coagulation of the Blood.Q41036958
Identification of the Staphylococcus aureus MSCRAMM clumping factor B (ClfB) binding site in the alphaC-domain of human fibrinogenQ41066583
Activation of a pro-enzyme by a stoichiometric reaction with another protein. The reaction between prothrombin and staphylocoagulaseQ41067903
Region X, the cell-wall-attachment part of staphylococcal protein A.Q41593374
Dabigatran Inhibits Staphylococcus aureus Coagulase ActivityQ42036878
The involvement of lactoferrin in the hyposideremia of acute inflammationQ42091283
Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN.Q42110792
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organsQ42146910
Specificity of the thioester-containing reactive site of human C3 and its significance to complement activationQ42828955
Selection and characterization of murine monoclonal antibodies to Staphylococcus aureus iron-regulated surface determinant B with functional activity in vitro and in vivo.Q43071917
Demonstration of the iron-regulated surface determinant (Isd) heme transfer pathway in Staphylococcus aureus.Q43156017
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanismsQ43508044
Virulence of coagulase-deficient mutants of Staphylococcus aureus in experimental endocarditisQ43543736
Identification and characterization of the Staphylococcus aureus gene cluster coding for staphyloferrin A.Q43622052
Expression and function of adenosine receptors in human dendritic cellsQ43726407
Thrombin stimulates the adherence of neutrophils to human endothelial cells in vitroQ34569233
Genetics and assembly line enzymology of siderophore biosynthesis in bacteriaQ34647692
S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formationQ34722335
Mechanisms of thrombus formationQ34815800
Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiationQ34859818
Characterization of a protective monoclonal antibody recognizing Staphylococcus aureus MSCRAMM protein clumping factor A.Q34944592
Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremiaQ34973729
IsdA and IsdB antibodies protect mice against Staphylococcus aureus abscess formation and lethal challengeQ34983585
Staphylococcus aureus transporters Hts, Sir, and Sst capture iron liberated from human transferrin by Staphyloferrin A, Staphyloferrin B, and catecholamine stress hormones, respectively, and contribute to virulenceQ35075837
Activation of a Proteolytic System by a Membrane Lipoprotein: Mechanism of Action of Tissue FactorQ35094854
Vaccine assembly from surface proteins of Staphylococcus aureus.Q35130822
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activationQ35204647
Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization.Q35220663
Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responsesQ35225082
Role of Staphylococcus aureus coagulase and clumping factor in pathogenesis of experimental endocarditisQ35455244
Development of StaphVAX, a polysaccharide conjugate vaccine against S. aureus infection: from the lab bench to phase III clinical trialsQ35710192
A B cell superantigen-induced persistent "Hole" in the B-1 repertoireQ35834654
A Staphylococcus aureus regulatory system that responds to host heme and modulates virulenceQ36154241
Role of siderophore biosynthesis in virulence of Staphylococcus aureus: identification and characterization of genes involved in production of a siderophoreQ36227179
Staphylococcal complement evasion by various convertase-blocking molecules.Q36228970
The ingestion and digestion of human lactoferrin by mouse peritoneal macrophages and the transfer of its iron into ferritinQ36335854
Molecular insights into the pathogenesis of hereditary haemochromatosisQ36419082
Neutrophils Influence the Level of Antigen Presentation during the Immune Response to Protein Antigens in AdjuvantsQ36432999
Community-associated meticillin-resistant Staphylococcus aureusQ36438720
Specific inhibition of Escherichia coli ferrienterochelin uptake by a normal human serum immunoglobulin.Q36442492
Direct hemin transfer from IsdA to IsdC in the iron-regulated surface determinant (Isd) heme acquisition system of Staphylococcus aureusQ36658328
Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response.Q36672835
Complement-mediated activation of the adaptive immune responses: role of C3d in linking the innate and adaptive immunityQ36751636
Association of hemochromatosis with infectious diseases: expanding spectrumQ36864775
Anti-Clumping Factor A Immunoglobulin Reduces the Duration of Methicillin-ResistantStaphylococcus aureusBacteremia in an Experimental Model of Infective EndocarditisQ36880839
Passage of heme-iron across the envelope of Staphylococcus aureus.Q44307087
Identification of a novel iron regulated staphylococcal surface protein with haptoglobin-haemoglobin binding activityQ44927238
Function of C3 in a humoral response: iC3b/C3dg bound to an immune complex generated with natural antibody and a primary antigen promotes antigen uptake and the expression of co-stimulatory molecules by all B cells, but only stimulates immunoglobuliQ44983018
Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infectionQ45733086
Age-associated changes in binding of human B lymphocytes to a VH3-restricted unconventional bacterial antigenQ45932908
Effect of the introduction of 'Healthy Start' on dietary behaviour during and after pregnancy: early results from the 'before and after' Sheffield studyQ46239758
Recent Advances in Haptoglobin and Transferrin GeneticsQ46309895
Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.Q46838216
Heme binding properties of Staphylococcus aureus IsdE.Q46955356
In vivo heme scavenging by Staphylococcus aureus IsdC and IsdE proteinsQ47234779
Evolution of type-specific immunoassays to evaluate the functional immune response to Gardasil: a vaccine for human papillomavirus types 16, 18, 6 and 11.Q47794837
Molecular characterization of the clumping factor (fibrinogen receptor) of Staphylococcus aureusQ48086155
The coagulase of Staphylococcus aureus 8325-4. Sequence analysis and virulence of site-specific coagulase-deficient mutantsQ48273054
Nucleotide sequence of the staphylocoagulase gene: its unique COOH-terminal 8 tandem repeatsQ48335846
Staphylococcal coagulase; mode of action and antigenicity.Q51043511
Dependence of germinal center B cells on expression of CD21/CD35 for survival.Q52039603
The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-Fc alpha RI binding and serum killing of bacteriaQ52841509
MntR modulates expression of the PerR regulon and superoxide resistance in Staphylococcus aureus through control of manganese uptake.Q53970053
Use of a Staphylococcus aureus conjugate vaccine in patients receiving hemodialysis.Q53979462
The impact of antimicrobial-resistant, health care-associated infections on mortality in the United States.Q54417681
Molecular cloning and expression of the coagulase gene of Staphylococcus aureus 8325-4.Q54755609
Iron acquisition by the haem-binding Isd proteins inStaphylococcus aureus: studies of the mechanism using magnetic circular dichroismQ58051148
Repetitive Sequences in Protein A from Staphylococcus aureus. Arrangement of Five Regions within the Protein, Four being Highly Homologous and Fc-BindingQ67010897
Binding of glycoprotein IIIa-derived peptide 217-231 to fibrinogen and von Willebrand factors and its inhibition by platelet glycoprotein IIb/IIIa complexQ68073842
Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complexQ68506495
Human IgM molecules that bind staphylococcal protein A contain VHIII H chainsQ69187430
Altered virulence of a pleiotropic Staphylococcus aureus mutant with a low producibility of coagulase and other factors in miceQ69443479
Antithrombotic activity of glomerular adenosine diphosphatase in the glomerular basement membrane of the rat kidneyQ70161979
Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factorQ70237272
Identification of a region of human fibrinogen interacting with staphylococcal clumping factorQ70331710
Isolation, characterization, and synthesis of peptides from human fibrinogen that block the staphylococcal clumping reaction and construction of a synthetic clumping particleQ70331714
Relationship among plasma iron, plasma iron turnover, and reticuloendothelial iron releaseQ70427591
Pulmonary neutrophil kinetics after thrombin-induced intravascular coagulationQ70502151
StaphylocoagulaseQ70873635
Identification of a site in fibrin(ogen) which is involved in the acceleration of plasminogen activation by tissue-type plasminogen activatorQ71235444
Effect of the carbocyclic nucleoside analogue MDL 201,112 on inhibition of interferon-gamma-induced priming of Lewis (LEW/N) rat macrophages for enhanced respiratory burst and MHC class II Ia+ antigen expressionQ72153007
Protein A is the von Willebrand factor binding protein on Staphylococcus aureusQ74296184
Iron-source preference of Staphylococcus aureus infectionsQ80551515
Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensingQ80628132
Clinical trial of safety and efficacy of INH-A21 for the prevention of nosocomial staphylococcal bloodstream infection in premature infantsQ80844725
Direct interaction of iron-regulated surface determinant IsdB of Staphylococcus aureus with the GPIIb/IIIa receptor on plateletsQ82231973
Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytesQ82660148
Identification of in vivo-expressed antigens of Staphylococcus aureus and their use in vaccinations for protection against nasal carriageQ82862847
P433issue2
P921main subjectStaphylococcus aureusQ188121
P304page(s)317-333
P577publication date2011-12-01
P1433published inSeminars in ImmunopathologyQ15724576
P1476titleExploring Staphylococcus aureus pathways to disease for vaccine development
P478volume34

Reverse relations

cites work (P2860)
Q36277405Abscess formation and alpha-hemolysin induced toxicity in a mouse model of Staphylococcus aureus peritoneal infection.
Q41204924Adjuvant-dependent immunogenicity of Staphylococcus aureus Efb and Map proteins in chickens.
Q50116528Altered immune proteome of Staphylococcus aureus under iron-restricted growth conditions
Q35765208Attenuation of Staphylococcus aureus-Induced Bacteremia by Human Mini-Antibodies Targeting the Complement Inhibitory Protein Efb
Q36277411Coagulases as determinants of protective immune responses against Staphylococcus aureus
Q57072739Essential Domain-Dependent Roles Within Soluble IgG for Superantigen Properties of Staphylococcal Protein A: Resolving the B-Cell Superantigen Paradox
Q35063930Evaluation of the protective immunity of a novel subunit fusion vaccine in a murine model of systemic MRSA infection
Q59806683Models matter: the search for an effective Staphylococcus aureus vaccine
Q38207403Mouse models for infectious diseases caused by Staphylococcus aureus.
Q93220831PPE37 Is Essential for Mycobacterium tuberculosis Heme-Iron Acquisition (HIA), and a Defective PPE37 in Mycobacterium bovis BCG Prevents HIA
Q35069186Phagocytosis escape by a Staphylococcus aureus protein that connects complement and coagulation proteins at the bacterial surface
Q36277427Protein A-specific monoclonal antibodies and prevention of Staphylococcus aureus disease in mice
Q38037549The iron-regulated staphylococcal lipoproteins.
Q30415990The potential use of toxin antibodies as a strategy for controlling acute Staphylococcus aureus infections
Q36368669Vaccination with a UV-irradiated genetically attenuated mutant of Staphylococcus aureus provides protection against subsequent systemic infection.
Q34596203Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection
Q26828726Where does a Staphylococcus aureus vaccine stand?

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