Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction

scientific article published on 8 July 2006

Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P6179Dimensions Publication ID1022743094
P356DOI10.1186/1465-9921-7-97
P932PMC publication ID1533821
P698PubMed publication ID16827942
P5875ResearchGate publication ID6957315

P50authorBernd SchmeckQ56154185
Stefan HippenstielQ56955854
Bastian OpitzQ56958356
Norbert SuttorpQ56960665
P2860cites workCell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2Q22010443
Translating the Histone CodeQ22065840
TLR4 mutations are associated with endotoxin hyporesponsiveness in humansQ22254186
Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptorQ22254266
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 GeneQ22299417
A Toll-like receptor recognizes bacterial DNAQ24290668
Discrimination of bacterial lipoproteins by Toll-like receptor 6Q24291383
Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transductionQ24291653
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systemsQ24292468
Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cellsQ33768874
Synergistic proinflammatory responses induced by polymicrobial colonization of epithelial surfacesQ33927605
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.Q33982897
Toll-like receptor 3 is induced by and mediates antiviral activity against rhinovirus infection of human bronchial epithelial cellsQ33984176
Antimicrobial peptides and proteins in the innate defense of the airway surfaceQ34129369
NODs: intracellular proteins involved in inflammation and apoptosisQ34199862
Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cellsQ34206808
Bacterial invasion: the paradigms of enteroinvasive pathogensQ34312229
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity islandQ34359740
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signalingQ34361655
TLR signaling in the gut in health and diseaseQ34409408
NOD-LRR proteins: role in host-microbial interactions and inflammatory diseaseQ34426050
Lung dendritic cells and host immunity to infectionQ34444352
Role of T- and B-lymphocytes in pulmonary host defencesQ34470746
Tumor necrosis factor alpha enhances influenza A virus-induced expression of antiviral cytokines by activating RIG-I gene expression.Q34545737
Human metapneumovirus as a major cause of human respiratory tract diseaseQ34553072
Estimates of world-wide distribution of child deaths from acute respiratory infectionsQ34562287
Respiratory viral infections in adults.Q34618111
Lung epithelial fluid transport and the resolution of pulmonary edemaQ34711181
Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infectionQ34762735
Inflammation and surfactantQ35012022
Antimicrobial peptides: current status and therapeutic potentialQ35056723
Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infectionQ35060264
Differential response of human lung epithelial cells to fas-induced apoptosisQ35098447
Host innate defenses in the lung: the role of cytokinesQ35160604
Injury and repair in lung and airwaysQ35195641
Inflammatory response to infectious pulmonary injury.Q35208250
Epigenetic targets in hematopoietic malignanciesQ35551110
Processes involved in the repair of injured airway epithelia.Q35588367
Innate immunity in the lung: how epithelial cells fight against respiratory pathogensQ35673699
Viral pneumoniae in children: incidence and aetiologyQ35674209
Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and childrenQ35697523
The innate immune response to pneumococcal lung infection: the untold story.Q35702813
Toll-like receptors: function and roles in lung diseaseQ35738175
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.Q42453950
Expression of functional toll-like receptor-2 and -4 on alveolar epithelial cells.Q42459176
Toll-like receptors 4 and 2 expression in the bronchial mucosa of patients with cystic fibrosisQ42475747
Decreased bacterial clearance from the lungs of mice following primary respiratory syncytial virus infectionQ43638052
Nosocomial pneumonia in ventilated patients: a cohort study evaluating attributable mortality and hospital stayQ43798721
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitmentQ43822750
Preparing the target for the bulletQ43830785
Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cellsQ44383838
Structural requirements of synthetic muropeptides to synergize with lipopolysaccharide in cytokine inductionQ44688386
Transmigration across a lung epithelial monolayer delays apoptosis of polymorphonuclear leukocytesQ44705371
Impact of methicillin resistance on outcome of Staphylococcus aureus ventilator-associated pneumoniaQ44970315
Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotorQ45107803
Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virusQ45173711
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processingQ45251378
Association between common Toll-like receptor 4 mutations and severe respiratory syncytial virus diseaseQ45640302
Neutrophil defensins stimulate the release of cytokines by airway epithelial cells: modulation by dexamethasoneQ45711894
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virusQ45739890
Toll-like receptor 4 mediates innate immune responses to Haemophilus influenzae infection in mouse lungQ45882366
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine releaseQ46477488
Expression of toll-like receptor 2 and 4 in lipopolysaccharide-induced lung injury in mouseQ46497808
Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modificationQ46664076
Legionella pneumophila replicates within rat alveolar epithelial cellsQ46768163
Exposure to inhalable dust and endotoxins in agricultural industriesQ46881304
Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cellsQ47225624
Both hemopoietic and resident cells are required for MyD88-dependent pulmonary inflammatory response to inhaled endotoxinQ47695986
Inflammatory response of tracheobronchial epithelial cells to endotoxinQ47745907
Critically ill patients with severe acute respiratory syndromeQ47757064
Angiotensin-converting enzyme 2 protects from severe acute lung failureQ47768368
Inhibition of respiratory viruses by nasally administered siRNA.Q47874231
NF-kappaB activation and sustained IL-8 gene expression in primary cultures of cystic fibrosis airway epithelial cells stimulated with Pseudomonas aeruginosaQ47903430
Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophilaQ48269403
T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genesQ50111962
Toll-like receptors in normal and cystic fibrosis airway epithelial cells.Q51640425
Ventilator-associated pneumonia after heart surgery: a prospective analysis and the value of surveillance.Q51664584
A prominent role for airway epithelial NF-kappa B activation in lipopolysaccharide-induced airway inflammation.Q51669271
Selective I kappa B kinase expression in airway epithelium generates neutrophilic lung inflammation.Q51691454
Interleukin-8: a very important chemokine of the human airway epithelium.Q51704308
ICAM-1 facilitates alveolar macrophage phagocytic activity through effects on migration over the AEC surface.Q51714162
TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells.Q52550005
Chlamydophila pneumoniae. Mechanisms of target cell infection and activation.Q53846567
The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation.Q53875945
Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila.Q53944716
Decreased histone deacetylase activity in chronic obstructive pulmonary disease.Q54664094
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionQ24292675
A20 inhibits toll-like receptor 2- and 4-mediated interleukin-8 synthesis in airway epithelial cellsQ24293016
Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involvedQ24295020
CATERPILLER: a novel gene family important in immunity, cell death, and diseasesQ24298131
NLRs join TLRs as innate sensors of pathogensQ24305830
Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognitionQ24306842
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Q24310398
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon inductionQ24318426
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virusQ24336255
The CATERPILLER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor alpha-, and Mycobacterium tuberculosis-induced pro-inflammatory signalsQ24337585
Nod1-mediated endothelial cell activation by Chlamydophila pneumoniaeQ24338210
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoterQ24558779
The evolution of H5N1 influenza viruses in ducks in southern ChinaQ24564166
Toll-like receptor signallingQ24570126
LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFQ24672442
Alveolar epithelial type II cell: defender of the alveolus revisitedQ24791750
Human lung cancer cells express functionally active Toll-like receptor 9Q24802960
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosisQ24811631
Ambient endotoxin concentrations in PM10 from Southern CaliforniaQ24811844
Characterization of Toll-like receptors in primary lung epithelial cells: strong impact of the TLR3 ligand poly(I:C) on the regulation of Toll-like receptors, adaptor proteins and inflammatory responseQ24812201
Bench-to-bedside review: antimicrobial utilization strategies aimed at preventing the emergence of bacterial resistance in the intensive care unitQ24813204
Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunityQ25257710
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA virusesQ27860455
Toll-like receptorsQ27860671
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responsesQ27860685
Innate immune recognitionQ27860721
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Q27860854
The language of covalent histone modificationsQ27860931
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3Q27861127
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6Q28115232
Economic costs of respiratory tract infections in the United StatesQ93588508
A previously undescribed coronavirus associated with respiratory disease in humansQ37647570
Heat shock protein 60 from Chlamydia pneumoniae elicits an unusual set of inflammatory responses via Toll-like receptor 2 and 4 in vivoQ37866477
Etiology of community-acquired pneumonia in hospitalized school-age children: evidence for high prevalence of viral infections.Q37866520
Epidemiology and clinical characteristics of community-acquired pneumonia in hospitalized childrenQ37867448
Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniaeQ37871262
Infection and activation of airway epithelial cells by Chlamydia pneumoniaeQ37875332
Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epitheliumQ38316780
Stimulation via Toll-like receptor 9 reduces Cryptococcus neoformans-induced pulmonary inflammation in an IL-12-dependent mannerQ38333159
Bordetella bronchiseptica flagellin is a proinflammatory determinant for airway epithelial cellsQ39392310
Adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2.Q39603489
Deletion of TLR3 alters the pulmonary immune environment and mucus production during respiratory syncytial virus infectionQ40327306
Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cellsQ40327372
Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reductionQ40332613
Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cellsQ40349264
Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cellsQ40382473
TLR2 signaling is critical for Mycoplasma pneumoniae-induced airway mucin expressionQ40432568
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon inductionQ40437839
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} inductionQ40446857
NOD1 variation, immunoglobulin E and asthma.Q40457038
TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells.Q40468230
hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cellsQ40497021
Different domains of Pseudomonas aeruginosa exoenzyme S activate distinct TLRsQ40533098
Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniaeQ40542030
TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cellsQ40555493
Respiratory epithelial cells regulate lung inflammation in response to inhaled endotoxinQ40572941
Outer membrane protein A from Klebsiella pneumoniae activates bronchial epithelial cells: implication in neutrophil recruitment.Q40609285
Pseudomonas aeruginosa Flagella Activate Airway Epithelial Cells through asialoGM1 and Toll-Like Receptor 2 as well as Toll-Like Receptor 5Q40618435
Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways: evidence for an intracellular compartmentalization of TLR4.Q40619554
Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin.Q40625076
Modulation of human beta-defensin-2 transcription in pulmonary epithelial cells by lipopolysaccharide-stimulated mononuclear phagocytes via proinflammatory cytokine productionQ40656602
Human neutrophil defensins induce lung epithelial cell proliferation in vitro.Q40720263
Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-kappaB translocationQ40815279
Cell cycle kinetics in the alveolar epitheliumQ41534972
VISA is an adapter protein required for virus-triggered IFN-beta signalingQ28131814
Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in respiratory epitheliaQ28145673
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5Q28185796
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayQ28190704
Triggering the interferon antiviral response through an IKK-related pathwayQ28191761
On the role of IRF in host defenseQ28201598
Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's diseaseQ28201834
Involvement of receptor-interacting protein 2 in innate and adaptive immune responsesQ28207221
Negative regulation of toll-like receptor-mediated signaling by TollipQ28212686
Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cellsQ28215261
Histone acetylation and deacetylation: importance in inflammatory lung diseasesQ28237379
The cytosolic pattern-recognition receptor Nod2 and inflammatory granulomatous disordersQ28253790
Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2Q28259599
A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injuryQ28260798
Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1Q28271523
Regulation of the type I IFN induction: a current viewQ28276339
Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factorQ28289854
Cryopyrin activates the inflammasome in response to toxins and ATPQ28291313
Interactions between neutrophil-derived antimicrobial peptides and airway epithelial cellsQ28297764
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptorsQ28303818
The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signalingQ28306258
CARD4/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.Q28344579
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathwayQ28505835
The adaptor molecule TIRAP provides signalling specificity for Toll-like receptorsQ28511605
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNAQ28513215
Identification of Lps2 as a key transducer of MyD88-independent TIR signallingQ28587545
Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractQ28587612
NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesQ28588300
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathwayQ28592087
The two NF-kappaB activation pathways and their role in innate and adaptive immunityQ29614355
Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1Q29614473
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3Q29615598
MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathwaysQ29616209
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycanQ29618544
Negative regulation of toll-like receptor-mediated immune responsesQ29619019
Community-acquired pneumoniaQ57117893
Nod1 Participates in the Innate Immune Response toPseudomonas aeruginosaQ57245053
TLR1- and TLR6-independent Recognition of Bacterial LipopeptidesQ58003723
Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in hQ60333675
Pulmonary Defence MechanismsQ63370912
Targeted immunomodulation of the NF-kappaB pathway in airway epithelium impacts host defense against Pseudomonas aeruginosaQ64377918
Community-acquired pneumoniaQ72077200
Infectivity of Legionella pneumophila mip mutant for alveolar epithelial cellsQ72275753
The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defenseQ73049177
Decreased pulmonary clearance of S. pneumoniae following influenza A infection in miceQ73835887
Pneumocystis carinii induces ICAM-1 expression in lung epithelial cells through a TNF-alpha-mediated mechanismQ74065519
Nosocomial pneumonia in patients with acute respiratory distress syndromeQ74490002
Interaction of human neutrophils with airway epithelial cells: reduction of leukotriene B4 generation by epithelial cell derived prostaglandin E2Q74510306
Rho protein inhibition blocks protein kinase C translocation and activationQ74550812
Community-acquired pneumoniaQ75190399
Unresponsiveness of MyD88-deficient mice to endotoxinQ78093558
Regulation of polymorphonuclear leukocyte apoptosis: role of lung endothelium-epithelium bilayer transmigrationQ80843743
Ventilator-associated pneumoniaQ81628428
The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infectionQ82412798
An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidQ29620015
Surfactant Proteins A and D and Pulmonary Host DefenseQ30049091
Rhinovirus and the lower respiratory tractQ30312290
Genesis of a highly pathogenic and potentially pandemic H5N1 influenza virus in eastern Asia.Q30342179
Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses.Q30350277
Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5.Q30447044
Association of NOD1 polymorphisms with atopic eczema and related phenotypesQ30786922
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammationQ30819243
Identification of genes induced by inflammatory cytokines in airway epitheliumQ30985468
Hospital-acquired pneumonia: risk factors, microbiology, and treatmentQ31920726
Molecular mechanisms of pulmonary peptidomimetic drug and peptide transport.Q33198362
Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cellsQ33209193
Recent advances in the epidemiology, prevention, diagnosis, and treatment of fungal pneumoniaQ33342057
Severe acute respiratory syndromeQ33359990
Cytokines in asthmaQ33717312
Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression.Q33737766
Pneumocystis pneumoniaQ35800451
The measurement and health impact of endotoxin contamination in organic dusts from multiple sources: focus on the cotton industryQ35809699
RNAi knock-down mice: an emerging technology for post-genomic functional genetics.Q35827791
The role of Toll-like receptors and Nod proteins in bacterial infectionQ35914426
Epidemiology and etiology of community-acquired pneumoniaQ35957889
Interactions between pulmonary surfactant and alveolar macrophages in the pathogenesis of lung diseaseQ35972788
The lung collectins, SP-A and SP-D, modulate pulmonary innate immunityQ35979097
Viruses in asthma exacerbationsQ35980672
The Icm/Dot type-IV secretion systems of Legionella pneumophila and Coxiella burnetiiQ36010820
Pathogen-host interactions in Pseudomonas aeruginosa pneumoniaQ36032639
Rnai as an experimental and therapeutic tool to study and regulate physiological and disease processes.Q36040998
Type I interferons (alpha/beta) in immunity and autoimmunityQ36072422
Etiology of community-acquired pneumoniaQ36085157
Pneumonia in the elderly (geriatric) populationQ36092641
Intestinal epithelial TOLLerance versus inTOLLerance of commensalsQ36097458
Clinical significance of pneumococcal resistance and factors influencing outcomes.Q36104421
New fluoroquinolones in lower respiratory tract infections and emerging patterns of pneumococcal resistanceQ36154321
Interactions between LPS and lung surfactant proteinsQ36159088
Pathogen recognition with Toll-like receptorsQ36159961
The host type I interferon response to viral and bacterial infectionsQ36178864
The Toll-like receptors: analysis by forward genetic methodsQ36185195
Stem cells of the alveolar epitheliumQ36197188
Toll-like receptors and chronic lung disease.Q36201618
The yin and yang of type I interferon activity in bacterial infectionQ36234715
Overview of virus-induced airway disease.Q36237050
Effects of flagellin on innate and adaptive immunityQ36240129
Human antimicrobial peptides: defensins, cathelicidins and histatinsQ36282170
Type III secretion: the bacteria-eukaryotic cell express.Q36282457
Cytomegalovirus pneumonia in transplant recipientsQ36303294
Toll-like receptor expression and function in airway epithelial cells.Q36325573
A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' DiseaseQ36371497
Bacterial adhesion and entry into host cellsQ36404646
An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumoniaQ37273958
P275copyright licenseCreative Commons AttributionQ6905323
Creative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthospital-acquired infectionQ215509
signal transductionQ828130
viral pneumoniaQ2603200
pneumococcal pneumoniaQ7205992
epitheliumQ41301
lungQ7886
respiratory syncytial virus infectious diseaseQ18554367
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)97
P577publication date2006-07-08
P1433published inRespiratory ResearchQ7315904
P1476titleLung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction
P478volume7

Reverse relations

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Q31081134Scavenger receptors in human airway epithelial cells: role in response to double-stranded RNA
Q35770809Staphylococcus aureus Inhibits IL-8 Responses Induced by Pseudomonas aeruginosa in Airway Epithelial Cells.
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Q36845161Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice.
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Q52926578[New aspects of the pathophysiology of pneumonia].

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