A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis

scientific article published on 7 January 2013

A1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1167/IOVS.12-10050
P932PMC publication ID3544424
P698PubMed publication ID23211825
P5875ResearchGate publication ID233848690

P2093author name stringGennadiy Moiseyev
Jian-Xing Ma
Zhao Liu
Rando Allikmets
Jian Kong
Kazunori Yamamoto
Konstantin Petrukhin
Nicoleta Dobri
Qiong Qin
Janet R Sparrow
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A2E, a byproduct of the visual cycleQ28609934
Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal DiseasesQ29012269
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Effects of potent inhibitors of the retinoid cycle on visual function and photoreceptor protection from light damage in miceQ33931582
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Fenretinide activates caspases and induces apoptosis in gliomasQ34876630
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The coactivator LXXLL nuclear receptor recognition motif.Q35721024
Synthetic retinoids as inducers of apoptosis in ovarian carcinoma cell linesQ35750446
The bisretinoids of retinal pigment epitheliumQ35785390
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Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinalQ36052545
Lecithin:retinol acyltransferase is critical for cellular uptake of vitamin A from serum retinol-binding proteinQ36097928
RPE lipofuscin and its role in retinal pathobiologyQ36111032
New therapeutic targets in atrophic age-related macular degenerationQ36804427
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.Q37415751
Hemangiosarcoma in rodents: mode-of-action evaluation and human relevanceQ37518959
Assay of retinol-binding protein-transthyretin interaction and techniques to identify competing ligandsQ39692377
N-(4-hydroxyphenyl)retinamide induces apoptosis in human retinal pigment epithelial cells: retinoic acid receptors regulate apoptosis, reactive oxygen species generation, and the expression of heme oxygenase-1 and Gadd153.Q40232126
beta-Carotene conversion into vitamin A in human retinal pigment epithelial cellsQ40368582
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formationQ42164095
A novel mechanism by which N-(4-hydroxyphenyl)retinamide inhibits breast cancer cell growth: the production of nitric oxide.Q44248596
Fundus autofluorescence and age-related macular degenerationQ44309998
Retinyl esters are the substrate for isomerohydrolase.Q44318523
Retinoid receptor-dependent and independent biological activities of novel fenretinide analogues and metabolites.Q44615083
Sensitivity to DNA damage is a common component of hormone-based strategies for protection of the mammary glandQ46669847
Effects of N-(4-hydroxyphenyl)retinamide on vitamin A metabolism in rats.Q50921467
Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration.Q52525243
Binding affinities of retinol and related compounds to retinol binding proteinsQ52851433
In vitro interaction of fenretinide with plasma retinol-binding protein and its functional consequencesQ67546270
Interactions of retinol with binding proteins: implications for the mechanism of uptake by cellsQ68817215
Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cellsQ71275163
N-(4-hydroxyphenyl)retinamide (fenretinide) induces retinol-binding protein secretion from liver and accumulation in the kidneys in ratsQ72901738
Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscopeQ73089239
Retinol binding protein as a surrogate measure for serum retinol: studies in vitamin A-deficient children from the Republic of the Marshall IslandsQ73585715
High-performance liquid chromatography analysis of visual cycle retinoidsQ73758857
Retinoid receptor-dependent and -independent effects of N-(4-hydroxyphenyl)retinamide in F9 embryonal carcinoma cellsQ77804745
Fenretinide and risk reduction of second breast cancerQ79680224
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)85-95
P577publication date2013-01-07
P1433published inInvestigative Ophthalmology Visual ScienceQ6060707
P1476titleA1120, a nonretinoid RBP4 antagonist, inhibits formation of cytotoxic bisretinoids in the animal model of enhanced retinal lipofuscinogenesis
P478volume54

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cites work (P2860)
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