Neutrophils in development of multiple organ failure in sepsis

scientific article published on July 2006

Neutrophils in development of multiple organ failure in sepsis is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0140-6736(06)69005-3
P698PubMed publication ID16829300
P5875ResearchGate publication ID6956693

P50authorSusan D. BrainQ61849045
P2093author name stringD F Treacher
K A Brown
S D Brain
J D Pearson
S M Lewis
J D Edgeworth
P2860cites workCutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytesQ22254042
Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndromeQ24630405
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of careQ27860820
TREM-1 amplifies inflammation and is a crucial mediator of septic shockQ28185818
The dark side of C5a in sepsisQ28252425
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsQ28511151
Neutrophil maturation and activation determine anatomic site of clearance from circulationQ74514756
Acute G-CSF therapy is not protective during lethal E. coli sepsisQ74514852
Relevance of Fcgamma receptor and interleukin-10 polymorphisms for meningococcal diseaseQ77343540
Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator GroupQ77754946
Platelet and leukocyte activation correlate with the severity of septic organ dysfunctionQ77944475
Comparison of two polymorphisms of the interleukin-1 gene family: interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsisQ78124587
A two-insult in vitro model of PMN-mediated pulmonary endothelial damage: requirements for adherence and chemokine releaseQ78396050
Expression of CD64 as a potential marker of neonatal sepsisQ78513222
Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescenceQ79175268
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxisQ80512476
Time-course of sTREM (soluble triggering receptor expressed on myeloid cells)-1, procalcitonin, and C-reactive protein plasma concentrations during sepsisQ81628285
Reversing systemic inflammatory response syndrome with chemokine receptor pepducinsQ81725616
Critically III Anergic Patients Demonstrate Polymorphonuclear Neutrophil Activation in the Intravascular Compartment With Decreased Cell Delivery to Inflammatory FocciQ68261533
Hepatocyte injury during post-operative sepsis: activated neutrophils as potential mediatorsQ68520232
Inhibition of Corynebacterium parvum-primed and lipopolysaccharide-induced hepatic necrosis in rats by selective depletion of neutrophils using a monoclonal antibodyQ70590543
Changes in granulocyte colony-stimulating factor concentration in patients with trauma and sepsisQ71040003
Treatment of septic shock with the tumor necrosis factor receptor:Fc fusion protein. The Soluble TNF Receptor Sepsis Study GroupQ71094855
Sir Isaac Newton, sepsis, SIRS, and CARSQ71171155
Early neutrophil sequestration after injury: a pathogenic mechanism for multiple organ failureQ71515022
Shedding of L-selectin as a mechanism for reduced polymorphonuclear neutrophil exudation in patients with the systemic inflammatory response syndromeQ71764664
Altered leukocyte immunophenotypes in septic shock. Studies of HLA-DR, CD11b, CD14, and IL-2R expressionQ72093787
Interleukin-8 and development of adult respiratory distress syndrome in at-risk patient groupsQ72212878
Polymorphonuclear leukocyte activation. An early marker of the postsurgical sepsis responseQ72214004
Increased fMet-Leu-Phe receptor expression and altered superoxide production of neutrophil granulocytes in septic and posttraumatic patientsQ72312303
Microvascular function and rheologic changes in hyperdynamic sepsisQ72571917
Comparison of neutrophil and capillary diameters and their relation to neutrophil sequestration in the lungQ72913006
Differentiation of polymorphonuclear neutrophils in patients with systemic infections and chronic inflammatory diseases: evidence of prolonged life span and de novo synthesis of fibronectinQ72991647
Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptorsQ73015339
Ex vivo neutrophil function in response to three different doses of glycosylated rHuG-CSF (Lenograstim)Q73023534
Mechanisms for the diminished neutrophil exudation to secondary inflammatory sites in infected patients with a systemic inflammatory response (sepsis)Q73222212
Interleukin-2 involvement in early acute respiratory distress syndrome: relationship with polymorphonuclear neutrophil apoptosis and patient survivalQ73386619
Polymorphonuclear leukocytes released from the bone marrow preferentially sequester in lung microvesselsQ73784090
Difference in the responses after administration of granulocyte colony-stimulating factor in septic patients with relative neutropeniaQ73818608
Leucodepletion and the interaction of polymorphonuclear cells with endothelium in systemic inflammatory response syndromeQ73830957
Gene in a haystack: tumor necrosis factor polymorphisms and outcome in sepsisQ74245548
The high-affinity Fc gamma RI on PMN: regulation of expression and signal transductionQ74299696
Leukocyte activation in sepsis; correlations with disease state and mortalityQ74319479
Lipopolysaccharide protects polymorphonuclear leukocytes from apoptosis via tyrosine phosphorylation-dependent signal transduction pathwaysQ74427039
Increased distribution and expression of CD64 on blood polymorphonuclear cells from patients with the systemic inflammatory response syndrome (SIRS)Q74445953
Early trauma polymorphonuclear neutrophil responses to chemokines are associated with development of sepsis, pneumonia, and organ failureQ74459989
The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18Q28628809
The biochemistry of apoptosisQ29547741
Efficacy and safety of recombinant human activated protein C for severe sepsisQ29547839
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions ConferenceQ29618757
The pathophysiology and treatment of sepsisQ29619103
The immunopathogenesis of sepsisQ29622909
Expression patterns of the lipopolysaccharide receptor CD14, and the FCgamma receptors CD16 and CD64 on polymorphonuclear neutrophils: data from patients with severe bacterial infections and lipopolysaccharide-exposed cellsQ30764839
Resting murine neutrophils express functional alpha 4 integrins that signal through Src family kinases.Q32133674
Recognition of gram-negative bacteria and endotoxin by the innate immune systemQ33536549
Severe sepsis and septic shock. Definitions, epidemiology, and clinical manifestationsQ33893291
The inflammatory balance in human sepsisQ33953339
Leukokinetic studies. IV. The total blood, circulating and marginal granulocyte pools and the granulocyte turnover rate in normal subjectsQ34012154
Recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) in traumatic hemorrhagic shock: results of a phase II clinical trial. Traumatic Shock GroupQ34064380
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid productsQ34069723
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shockQ34145159
Immunologic and hemodynamic effects of "low-dose" hydrocortisone in septic shock: a double-blind, randomized, placebo-controlled, crossover studyQ34158467
Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in BrusselsQ34571280
Sepsis: current concepts in intracellular signalingQ34962385
Nitric oxide and the haemodynamic profile of endotoxin shock in the conscious mouseQ35027601
The role of the endothelium in severe sepsis and multiple organ dysfunction syndromeQ35051545
Disturbed homeostasis of lung intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 during sepsisQ35097439
Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing?Q35124230
The Toll-like receptors and their role in septic shockQ35537894
Interferon-gamma activation of polymorphonuclear neutrophil functionQ35750735
Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathwayQ35760642
Drug intervention trials in sepsis: divergent resultsQ35781583
Redox regulation of neutrophil apoptosis and the systemic inflammatory response syndrome.Q36098161
How monitoring of the microcirculation may help us at the bedsideQ36146606
Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzymeQ36349700
Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsisQ36369264
Protection from apoptosis in human neutrophils is determined by the surface of adhesionQ36847197
Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humansQ37282700
In vivo expression of neutrophil inhibitory factor via gene transfer prevents lipopolysaccharide-induced lung neutrophil infiltration and injury by a beta2 integrin-dependent mechanismQ37382637
Whole-body inflammation in trauma patients. An autopsy studyQ39540276
Adult respiratory distress syndrome in patients with severe neutropeniaQ39792747
Role of granulocyte colony-stimulating factor in the immune response to acute bacterial infection in the nonneutropenic host: an overviewQ40387669
Organism-specific neutrophil-endothelial cell interactions in response to Escherichia coli, Streptococcus pneumoniae, and Staphylococcus aureusQ40605205
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion.Q40752165
Reversal of nitric oxide-, peroxynitrite- and S-nitrosothiol-induced inhibition of mitochondrial respiration or complex I activity by light and thiolsQ40852732
Role of the neutrophil in adult respiratory distress syndromeQ40873286
Selectins and neutrophil traffic: margination and Streptococcus pneumoniae-induced emigration in murine lungsQ42104658
Expression of the adhesion molecule CD11b and polymerization of actin by polymorphonuclear granulocytes of patients endangered by sepsisQ42513733
Time-dependent reversal of sepsis-induced PMN uptake and lung vascular injury by expression of CD18 antagonistQ42518261
Neutrophils, not complement, mediate the mortality of experimental hemorrhagic pancreatitisQ43515492
The effects of leucodepletion in patients who develop the systemic inflammatory response syndrome following cardiopulmonary bypassQ43595852
Peaks of endogenous G-CSF serum concentrations are followed by an increase in respiratory burst activity of granulocytes in patients with septic shockQ43665093
A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. CAP Study Group.Q43711066
Delayed neutrophil apoptosis in sepsis is associated with maintenance of mitochondrial transmembrane potential and reduced caspase-9 activityQ43722700
Failure of neutrophil chemotactic function in septic patients.Q43990304
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.Q44021327
The effect of blockade of the CD11/CD18 integrin receptor on infarct size in patients with acute myocardial infarction treated with direct angioplasty: the results of the HALT-MI studyQ44182263
Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsisQ44207870
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator GroupQ44267568
Enhanced expression of intranuclear NF-kappa B in primed polymorphonuclear leukocytes in systemic inflammatory response syndrome patientsQ44310140
Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.Q44432142
Regulation of human neutrophil chemokine receptor expression and function by activation of Toll-like receptors 2 and 4.Q44434007
Toll-like receptors stimulate human neutrophil functionQ44493366
Fluconazole improves survival in septic shock: a randomized double-blind prospective studyQ44504266
Functional alpha4-integrin: a newly identified pathway of neutrophil recruitment in critically ill septic patientsQ44537382
Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in ratsQ44544726
Upregulation of reactive oxygen species generation and phagocytosis, and increased apoptosis in human neutrophils during severe sepsis and septic shockQ44552356
Three different neutrophil subsets exhibited in mice with different susceptibilities to infection by methicillin-resistant Staphylococcus aureusQ45016186
Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shockQ45041298
Gene expression profiling of inflamed human endothelial cells and influence of activated protein C.Q45124656
Effects of granulocyte colony stimulating factor in a nonneutropenic rodent model of Escherichia coli peritonitisQ45147743
CD18 adhesion blockade decreases bacterial clearance and neutrophil recruitment after intrapulmonary E. coli, but not after S. aureus.Q45180644
Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide modelQ45256622
Elevation of cardiac output and oxygen delivery improves outcome in septic shockQ46090707
Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2.Q47322920
Preferential loss of CXCR-2 receptor expression and function in patients who have undergone trauma.Q47327061
Neutrophils and oxygen-induced lung injury: a case of when a few is still too manyQ47683549
Expression of inducible nitric oxide synthase in circulating neutrophils of the systemic inflammatory response syndrome and septic patientsQ47804605
Transient leukocytosis, granulocyte colony-stimulating factor plasma concentrations, and apoptosis determined by binding of annexin V by peripheral leukocytes in patients with severe sepsisQ47916362
Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammationQ47944753
Neutrophil chemotaxis and receptor expression in clinical septic shockQ48022087
Inhibition of apoptosis and prolongation of neutrophil functional longevity by inflammatory mediators.Q50779072
Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion.Q51360856
Markers of systemic inflammation predicting organ failure in community-acquired septic shock.Q51435045
Sites of leukocyte sequestration in the pulmonary microcirculationQ51598068
Early alterations in neutrophil activation are associated with outcome in acute lung injury.Q51683184
INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis. International Sepsis Trial Study Group.Q53366008
Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomized, controlled, double-blind, multicenter clinical trial. TNF-alpha MAb Sepsis Study Group.Q53753081
Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome.Q54152127
Anti-tumor necrosis factor antibody treatment of recurrent bacteremia in a baboon model.Q54577356
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunctionQ57773627
Disseminated intravascular coagulationQ63368004
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shockQ64126988
A randomized prospective clinical trial to determine the efficacy of interferon-γ in severely injured patientsQ67752780
P433issue9530
P407language of work or nameEnglishQ1860
P921main subjectsepsisQ183134
P1104number of pages13
P304page(s)157-169
P577publication date2006-07-01
P1433published inThe LancetQ939416
P1476titleNeutrophils in development of multiple organ failure in sepsis
P478volume368

Reverse relations

cites work (P2860)
Q64102955A Comparative Review of Equine SIRS, Sepsis, and Neutrophils
Q27318669A Neutrophil Phenotype Model for Extracorporeal Treatment of Sepsis
Q28741030A biomimetic membrane device that modulates the excessive inflammatory response to sepsis
Q35989374A microfluidics approach towards high-throughput pathogen removal from blood using margination
Q57488630A model predicting short-term mortality in patients with advanced liver cirrhosis and concomitant infection
Q28249427A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5
Q82367429A quantitative study of lung dysfunction following haemorrhagic shock in rats
Q36757995AMP-activated protein kinase and Glycogen Synthase Kinase 3β modulate the severity of sepsis-induced lung injury
Q33399007ATP-gated P2X1 ion channels protect against endotoxemia by dampening neutrophil activation
Q37446058Activation of AMPK enhances neutrophil chemotaxis and bacterial killing
Q30503500Acute loss of renal function attenuates slow leukocyte rolling and transmigration by interfering with intracellular signaling
Q28486013Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development
Q30541964Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns
Q37077719An In Vivo and In Vitro Evaluation of the Mutual Interactions between the Lung and the Large Intestine
Q36070617Annexin A2 Modulates ROS and Impacts Inflammatory Response via IL-17 Signaling in Polymicrobial Sepsis Mice.
Q37399788Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
Q43145956Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury.
Q47434010Assessment of systemic inflammation by time-trends of blood granulocyte count and plasma myeloperoxidase and elastase concentrations following colic surgery in horses
Q92278515Association of the blood eosinophil count with end-organ symptoms
Q40272020Autophagy Primes Neutrophils for Neutrophil Extracellular Trap Formation during Sepsis.
Q34270607Baicalin improves survival in a murine model of polymicrobial sepsis via suppressing inflammatory response and lymphocyte apoptosis
Q26769674Balancing Innate Immunity and Inflammatory State via Modulation of Neutrophil Function: A Novel Strategy to Fight Sepsis
Q33394357Beyond thrombosis: the versatile platelet in critical illness
Q44636975Bioactive secondary metabolites of a marine Bacillus sp. inhibit superoxide generation and elastase release in human neutrophils by blocking formyl peptide receptor 1.
Q92494685Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis
Q33660802Blockade of ICAM-1 improves the outcome of polymicrobial sepsis via modulating neutrophil migration and reversing immunosuppression
Q33593368Blockade of Neutrophil's Chemokine Receptors CXCR1/2 Abrogate Liver Damage in Acute-on-Chronic Liver Failure
Q47096645Blood platelets and sepsis pathophysiology: A new therapeutic prospect in critical ill patients?
Q37664468Breaking the wall: targeting of the endothelium by pathogenic bacteria
Q36563509Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.
Q27334723Capillary plexuses are vulnerable to neutrophil extracellular traps
Q41758639Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility.
Q36610853Cell-based approaches for the treatment of systemic inflammation
Q33754578Circulating neutrophil counts and mortality in septic shock
Q38320684Circulating neutrophil dysfunction in acute liver failure.
Q53495293Circulating neutrophils of septic patients constitutively express IL-10R1 and are promptly responsive to IL-10.
Q34781952Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice
Q37194760Clinical relevance of pharmacokinetics and pharmacodynamics in cardiac critical care patients
Q102075445Co-delivery of resolvin D1 and antibiotics with nanovesicles to lungs resolves inflammation and clears bacteria in mice
Q40892746Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
Q44627674Comparative suitability of CFDA-SE and rhodamine 6G for in vivo assessment of leukocyte-endothelium interactions.
Q39001943Consequences of extracellular trap formation in sepsis
Q33409905Contribution of protein Z and protein Z-dependent protease inhibitor in generalized Shwartzman reaction
Q86350031Could abnormal neutrophil-platelet interactions and complex formation contribute to oxidative stress and organ failure in cirrhosis?
Q54428516Crucial role of Plexin C1 for pulmonary inflammation and survival during lung injury.
Q84764374Defective neutrophil rolling and transmigration in acute uremia
Q35725494Deoxyribonuclease is a potential counter regulator of aberrant neutrophil extracellular traps formation after major trauma
Q64108120Dependence of the severity of the systemic inflammatory response on resistance to hypoxia in male Wistar rats
Q41655928Depletion of high-affinity corticosteroid-binding globulin corresponds to illness severity in sepsis and septic shock; clinical implications
Q36633941Depletion of neutrophil extracellular traps in vivo results in hypersusceptibility to polymicrobial sepsis in mice
Q92122516Diagnosing Fracture-Related Infection: Current Concepts and Recommendations
Q57146976Diagnosis of sepsis from a drop of blood by measurement of spontaneous neutrophil motility in a microfluidic assay
Q38280048Differential effects of kidney-lung cross-talk during acute kidney injury and bacterial pneumonia
Q36592068Differential neutrophil responses to bacterial stimuli: Streptococcal strains are potent inducers of heparin-binding protein and resistin-release
Q36465420Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice
Q47161653Dual Functioned Pegylated Phospholipid Micelles Containing Cationic Antimicrobial Decapeptide for Treating Sepsis
Q39892030Dysfunction of Circulating Polymorphonuclear Leukocytes and Monocytes in Ambulatory Cirrhotics Predicts Patient Outcome
Q41212894Early enhanced local neutrophil recruitment in peritonitis-induced sepsis improves bacterial clearance and survival.
Q35533360Early hemorheological changes in a porcine model of intravenously given E. coli induced fulminant sepsis
Q33599723Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis
Q41701626Effect of phenolic acids of microbial origin on production of reactive oxygen species in mitochondria and neutrophils.
Q36633615Elevated plasma levels of heparin-binding protein in intensive care unit patients with severe sepsis and septic shock
Q41483092Embelin Reduces Systemic Inflammation and Ameliorates Organ Injuries in Septic Rats Through Downregulating STAT3 and NF-κB Pathways
Q33526332Endogenous morphine levels are increased in sepsis: a partial implication of neutrophils
Q40262427Enhanced Glycolytic Metabolism Contributes to Cardiac Dysfunction in Polymicrobial Sepsis
Q34192824Ensemble models of neutrophil trafficking in severe sepsis
Q46598464Erythrocyte sialoglycoproteins engage Siglec-9 on neutrophils to suppress activation
Q45825422Essential role of CCR2 in neutrophil tissue infiltration and multiple organ dysfunction in sepsis
Q45270728Evidence for the involvement of spinal cord-inhibitory and cytokines-modulatory mechanisms in the anti-hyperalgesic effect of hecogenin acetate, a steroidal sapogenin-acetylated, in mice.
Q35070188Excessive neutrophils and neutrophil extracellular traps contribute to acute lung injury of influenza pneumonitis
Q37276476Exocytosis acts as a modulator of the ILT4-mediated inhibition of neutrophil functions
Q37376251Exogenous carbon monoxide inhibits neutrophil infiltration in LPS-induced sepsis by interfering with FPR1 via p38 MAPK but not GRK2.
Q91878998Exosome-based delivery of super-repressor IκBα relieves sepsis-associated organ damage and mortality
Q89809698Experimental Approaches to Evaluate Leukocyte-Endothelial Cell Interactions in Sepsis and Inflammation
Q41118940Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation
Q36642067Expression of cell surface receptors and oxidative metabolism modulation in the clinical continuum of sepsis.
Q98177667Extracellular AMP Suppresses Endotoxemia-Induced Inflammation by Alleviating Neutrophil Activation
Q37576085Extracellular ATP mediates the late phase of neutrophil recruitment to the lung in murine models of acute lung injury
Q33864429Extracorporeal immune therapy with immobilized agonistic anti-Fas antibodies leads to transient reduction of circulating neutrophil numbers and limits tissue damage after hemorrhagic shock/resuscitation in a porcine model
Q90602550Flow Cytometric Analysis of Hematopoietic Populations in Rat Bone Marrow. Impact of Trauma and Hemorrhagic Shock
Q41094275Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic patient prognosis
Q46728270Flow-cytometric measurement of respiratory burst in rat polymorphonuclear granulocytes: Comparison of four cell preparation procedures, and concentration-response evaluation of soluble stimulants
Q28242064From neutrophil extracellular traps release to thrombosis: an overshooting host-defense mechanism?
Q40526734Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.
Q43094851Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia
Q37233942Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsis
Q45768669Glycogen synthase kinase-3β inactivation is an intracellular marker and regulator for endotoxemic neutrophilia.
Q92618188High expression of long non-coding RNA MALAT1 correlates with raised acute respiratory distress syndrome risk, disease severity, and increased mortality in sepstic patients
Q35537959Human severe sepsis cytokine mixture increases β2-integrin-dependent polymorphonuclear leukocyte adhesion to cerebral microvascular endothelial cells in vitro
Q46941767IL-10 modulates cytokine gene transcription by protein synthesis-independent and dependent mechanisms in lipopolysaccharide-treated neutrophils
Q40090316IL-23/IL-17/G-CSF pathway is associated with granulocyte recruitment to the lung during African swine fever
Q38412875IMMUNE CELL PHENOTYPE AND FUNCTION IN SEPSIS.
Q33683531IVIG regulates the survival of human but not mouse neutrophils
Q39323149Identification of Neutrophil Exocytosis Inhibitors (Nexinhibs), Small Molecule Inhibitors of Neutrophil Exocytosis and Inflammation: DRUGGABILITY OF THE SMALL GTPase Rab27a.
Q54651317Immune response in severe infection: could life-saving drugs be potentially harmful?
Q38174053Immunoinflammatory response in critically ill patients: severe sepsis and/or trauma
Q90101108Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting
Q37782568Immunosuppression following surgical and traumatic injury
Q35150494Immunotherapy reduces allergen-mediated CD66b expression and myeloperoxidase levels on human neutrophils from allergic patients
Q89514339In vivo monitoring of dynamic interaction between neutrophil and human umbilical cord blood-derived mesenchymal stem cell in mouse liver during sepsis
Q37460000Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients
Q50099251Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis.
Q35607212Increased plasma arginase activity in human sepsis: association with increased circulating neutrophils
Q35567208Increased serum soluble Fas after major trauma is associated with delayed neutrophil apoptosis and development of sepsis
Q27692695Inflection points in sepsis biology: from local defense to systemic organ injury
Q35159761Inhibition of neutrophil apoptosis by PAI-1.
Q52627246Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury.
Q40243993Initial patient assessment of infectious diseases and diagnostic steps with fever
Q37182717Innate immune-induced depletion of bone marrow neutrophils aggravates systemic bacterial infections
Q37364297Innate immunity in sepsis pathogenesis and its modulation: new immunomodulatory targets revealed
Q38429229Integrative model of leukocyte genomics and organ dysfunction in heart failure patients requiring mechanical circulatory support: a prospective observational study
Q43062147Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
Q79808379Ischemia-reperfusion injury is attenuated in VAP-1-deficient mice and by VAP-1 inhibitors
Q46065423Kupffer cells and activation of endothelial TLR4 coordinate neutrophil adhesion within liver sinusoids during endotoxemia
Q50333030L-4F inhibits lipopolysaccharide-mediated activation of primary human neutrophils.
Q52641478Leukadherin-1 ameliorates endothelial barrier damage mediated by neutrophils from critically ill patients.
Q43229992Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis
Q24297112Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function
Q45248748Linezolid dampens neutrophil-mediated inflammation in methicillin-resistant Staphylococcus aureus-induced pneumonia and protects the lung of associated damages
Q46600426Lipopolysaccharide-induced neutrophil extracellular trap formation in canine neutrophils is dependent on histone H3 citrullination by peptidylarginine deiminase
Q27307089Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis
Q34328435MMP-8 deficiency increases TLR/RAGE ligands S100A8 and S100A9 and exacerbates lung inflammation during endotoxemia
Q41082527Marked alterations of neutrophil functions during sepsis-induced immunosuppression
Q39361006Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid
Q43264874Mediators released from LPS-challenged lungs induce inflammatory responses in liver vascular endothelial cells and neutrophilic leukocytes.
Q64057196Mediatory roles of leukotriene B receptors in LPS-induced endotoxic shock
Q42655332MiR-125a Is a critical modulator for neutrophil development.
Q92329401Microfluidic arenas for war games between neutrophils and microbes
Q37598549Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis
Q39935785Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury
Q28386372Modulation of antigen processing by haem-oxygenase 1. Implications on inflammation and tolerance
Q34486324Modulation of chemokine gradients by apheresis redirects leukocyte trafficking to different compartments during sepsis, studies in a rat model.
Q36581980Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines
Q92797677Molecular nephrology: types of acute tubular injury
Q89681951Myeloperoxidase and Septic Conditions Disrupt Sphingolipid Homeostasis in Murine Brain Capillaries In Vivo and Immortalized Human Brain Endothelial Cells In Vitro
Q41685301Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS
Q47688030Myeloperoxidase-derived 2-chlorofatty acids contribute to human sepsis mortality via acute respiratory distress syndrome
Q89791124Narciclasine improves outcome in sepsis among neonatal rats via inhibition of calprotectin and alleviating inflammatory responses
Q37108504Neutropenic sepsis is associated with distinct clinical and biological characteristics: a cohort study of severe sepsis
Q52662331Neutrophil Chemotaxis in One Droplet of Blood Using Microfluidic Assays.
Q34580313Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis
Q41430132Neutrophil activation and nucleosomes as markers of systemic inflammation in paroxysmal nocturnal hemoglobinuria: effects of eculizumab
Q85409525Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation
Q38310658Neutrophil migration under normal and sepsis conditions
Q37959327Neutrophils and intravascular immunity in the liver during infection and sterile inflammation
Q58411881Neutrophils and sepsis
Q33753767Neutrophils from critically ill septic patients mediate profound loss of endothelial barrier integrity
Q49788597Neutrophils in critical illness.
Q55191874Neutrophils in traumatic brain injury (TBI): friend or foe?
Q26749490Neutrophils in type 1 diabetes
Q34667638Neutrophils with myeloid derived suppressor function deplete arginine and constrain T cell function in septic shock patients
Q35865602Neutrophils: the forgotten cell in JIA disease pathogenesis
Q28238087Nociceptin system as a target in sepsis?
Q91816604Oxidant/Antioxidant Disequilibrium in Idiopathic Pulmonary Fibrosis Pathogenesis
Q41381344Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.
Q35638779P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy
Q26747422Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious
Q37162759Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury
Q80210901Pathophysiology of sepsis
Q38116494Pathways mediating resolution of inflammation: when enough is too much
Q43259061Pentoxifylline modulates p47phox activation and downregulates neutrophil oxidative burst through PKA-dependent and -independent mechanisms
Q54671652Phosphoinositide-3 kinase gamma activity contributes to sepsis and organ damage by altering neutrophil recruitment.
Q48826884Plasma from patients with sepsis up-regulates the expression of CD49d and CD64 on blood neutrophils.
Q40190199Platelet P-selectin is significantly involved in leukocyte-endothelial cell interaction in murine antigen-induced arthritis
Q37996098Platelet-mediated vascular dysfunction during acute lung injury
Q41822249Prognostic Value and Daily Trend of Interleukin-6, Neutrophil CD64 Expression, C-Reactive Protein and Lipopolysaccharide-Binding Protein in Critically Ill Patients: Reliable Predictors of Outcome or Not?
Q93192067Prognostic factors for ARDS: clinical, physiological and atypical immunodeficiency
Q35659881Propofol Treatment Inhibits Constitutive Apoptosis in Human Primary Neutrophils and Granulocyte-Differentiated Human HL60 Cells
Q64066381Protection against Staphylococcus aureus bacteremia-induced mortality depends on ILC2s and eosinophils
Q84712589Protective effect and mechanism of sodium tanshinone II A sulfonate on microcirculatory disturbance of small intestine in rats with sepsis
Q48723737Protective effect of quercetin on lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammatory cell influx.
Q36330067R-roscovitine reduces lung inflammation induced by lipoteichoic acid and Streptococcus pneumoniae
Q36528361Reactive oxygen and nitrogen species in sepsis-induced hepatic microvascular dysfunction.
Q40693331Reactive oxygen species measure for rapid detection of infection in fluids
Q42950062Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases.
Q37129474Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis
Q40227118Regulation of the inflammatory response: enhancing neutrophil infiltration under chronic inflammatory conditions
Q99583742Reviewing the value of leukocytes cell population data (CPD) in the management of sepsis
Q46003435Role of T cells in a murine model of Escherichia coli sepsis.
Q38890353Role of cellular events in the pathophysiology of sepsis
Q36173771Role of β1 integrin in tissue homing of neutrophils during sepsis.
Q55313947Sepsis Induces a Dysregulated Neutrophil Phenotype That Is Associated with Increased Mortality.
Q35063462Sepsis induced by Staphylococcus aureus: participation of biomarkers in a murine model
Q34636844Sepsis lethality via exacerbated tissue infiltration and TLR-induced cytokine production by neutrophils is integrin α3β1-dependent.
Q40611797Sepsis-Induced Thymic Atrophy Is Associated with Defects in Early Lymphopoiesis
Q42588928Sepsis-associated disseminated intravascular coagulation and thromboembolic disease
Q38260709Sepsis-induced acute kidney injury revisited: pathophysiology, prevention and future therapies
Q33401213Septic shock and chemotherapy-induced cytopenia: effects on microcirculation
Q58577841Serum concentrations of endothelial cell adhesion molecules and their shedding enzymes and early onset sepsis in newborns in Suriname
Q90045402Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans
Q41571999Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils
Q41737170Sustained expression of lipocalin-2 during polymicrobial sepsis
Q35818580T-Cell Responses Are Associated with Survival in Acute Melioidosis Patients
Q98891612TICAM2-related pathway mediates neutrophil exhaustion
Q37182774TLR2-mediated neutrophil depletion exacerbates bacterial sepsis
Q38215408Targeting neutrophils in sepsis
Q88532056Temporal gradients limit the accumulation of neutrophils towards sources of chemoattractant
Q34325901Thaliporphine preserves cardiac function of endotoxemic rabbits by both directly and indirectly attenuating NFκB signaling pathway.
Q36088507The Aminopeptidase CD13 Induces Homotypic Aggregation in Neutrophils and Impairs Collagen Invasion
Q92856056The Role of Physiological Vitamin C Concentrations on Key Functions of Neutrophils Isolated from Healthy Individuals
Q64119457The Role of Tyrosine Phosphorylation of Protein Kinase C Delta in Infection and Inflammation
Q33908572The SaeR/S gene regulatory system induces a pro-inflammatory cytokine response during Staphylococcus aureus infection
Q35131890The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study
Q42821377The cardioprotective effect of hypertonic saline is associated with inhibitory effect on macrophage migration inhibitory factor in sepsis
Q35165213The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation.
Q87167093The effect of evolving trauma care on the development of multiple organ dysfunction syndrome
Q34486031The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice
Q37730796The impact of environmental enrichment on the murine inflammatory immune response
Q45189914The matri-cellular proteins 'cysteine-rich, angiogenic-inducer, 61' and 'connective tissue growth factor' are regulated in experimentally-induced sepsis with multiple organ dysfunction
Q45133458The plexin C1 receptor promotes acute inflammation
Q37775189The role of activated neutrophils in the early stage of equine laminitis
Q90604254The role of β2 integrins in neutrophils and sepsis
Q38305503The severity of circulating neutrophil dysfunction in patients with cirrhosis is associated with 90-day and 1-year mortality.
Q30586319The small GTPase Rap1b negatively regulates neutrophil chemotaxis and transcellular diapedesis by inhibiting Akt activation.
Q37741440The three Rs: Recruitment, Retention and Residence of leukocytes in the liver.
Q64360283The utility of peripheral blood leucocyte ratios as biomarkers in infectious diseases: A systematic review and meta-analysis
Q90589903Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases
Q53723228To What Extent Are the Terminal Stages of Sepsis, Septic Shock, Systemic Inflammatory Response Syndrome, and Multiple Organ Dysfunction Syndrome Actually Driven by a Prion/Amyloid Form of Fibrin?
Q58764818Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration
Q36408163Type 1 diabetes predisposes to enhanced gingival leukocyte margination and macromolecule extravasation in vivo
Q36627891Year in review in Intensive Care Medicine 2012. II: Pneumonia and infection, sepsis, coagulation, hemodynamics, cardiovascular and microcirculation, critical care organization, imaging, ethics and legal issues

Search more.