Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions

scientific article published on July 1992

Different extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.118.1.177
P932PMC publication ID2289517
P698PubMed publication ID1618903
P5875ResearchGate publication ID277424221

P50authorMelitta SchachnerQ1622212
P2093author name stringWille W
Frei T
von Bohlen und Halbach F
P2860cites workCharacterization of binding properties of the myelin-associated glycoprotein to extracellular matrix constituentsQ24556071
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Use of bacteriophage T7 RNA polymerase to direct selective high-level expression of cloned genesQ27860623
The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactionsQ27865264
Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicingQ28116105
The immunoglobulin superfamily--domains for cell surface recognitionQ28294978
Monoclonal antibody and ligand binding sites of the T cell erythrocyte receptor (CD2)Q28306302
The axonal glycoprotein TAG-1 is an immunoglobulin superfamily member with neurite outgrowth-promoting activityQ28576557
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2Q29614365
Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the moleculeQ29616413
Vectors for selective expression of cloned DNAs by T7 RNA polymeraseQ29620230
Differential exon usage involving an unusual splicing mechanism generates at least eight types of NCAM cDNA in mouse brainQ33559022
Isolation of mouse N-CAM-related cDNA: detection and cloning using monoclonal antibodiesQ33931012
Biosynthesis and membrane topography of the neural cell adhesion molecule L1.Q33931962
Neural adhesion molecule L1 as a member of the immunoglobulin superfamily with binding domains similar to fibronectinQ34178138
An L1-like molecule, the 8D9 antigen, is a potent substrate for neurite extensionQ34361199
Organization of the neural cell adhesion molecule (N-CAM) gene: alternative exon usage as the basis for different membrane-associated domainsQ34586870
Protein G: a powerful tool for binding and detection of monoclonal and polyclonal antibodiesQ34695493
Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryosQ34710476
Selective expression of the 180-kD component of the neural cell adhesion molecule N-CAM during developmentQ36213807
A heparin-binding domain from N-CAM is involved in neural cell-substratum adhesionQ36214415
Distribution of N-CAM in synaptic and extrasynaptic portions of developing and adult skeletal muscleQ36214493
Molecular forms of N-CAM and its RNA in developing and denervated skeletal muscleQ36214609
Topography of N-CAM structural and functional determinants. II. Placement of monoclonal antibody epitopesQ36215662
Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segmentQ36218423
Immunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerveQ36218527
Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous systemQ36219397
The mouse neuronal cell surface protein F3: a phosphatidylinositol-anchored member of the immunoglobulin superfamily related to chicken contactinQ36221337
Alteration of the retinotectal map in Xenopus by antibodies to neural cell adhesion moleculesQ36265335
Expression of the neural cell adhesion molecules L1 and N-CAM and their common carbohydrate epitope L2/HNK-1 during development and after transection of the mouse sciatic nerveQ68957745
Localization of the L2 monoclonal antibody binding site on chicken neural cell adhesion molecule (NCAM) and evidence for its role in NCAM-mediated cell adhesionQ69003698
Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth functionQ69136617
Identification of a heparin binding domain of the neural cell adhesion molecule N-CAM using synthetic peptidesQ69447082
Neural cell recognition molecule F11: homology with fibronectin type III and immunoglobulin type C domainsQ69451415
L1-mediated axon outgrowth occurs via a homophilic binding mechanismQ69451430
Small inhibitory cerebellar interneurons grow in a perpendicular orientation to granule cell neurites in cultureQ69570196
Monoclonal antibody against cell surface glycoprotein of neuronsQ70152297
Pathways and mechanisms of avian trunk neural crest cell migration and localizationQ70512177
Lateral Mobility of the Cell Adhesion Molecule L1 Within the Surface Membrane of Morphologically Undifferentiated and Differentiated Neuroblastoma CellsQ74429510
Molecular Association of the Neural Adhesion Molecules L1 and N-CAM in the Surface Membrane of Neuroblastoma Cells is Shown by Chemical Cross-linkingQ74430102
Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysisQ36356138
Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin functionQ36510361
Structure of the chicken neuron-glia cell adhesion molecule, Ng-CAM: origin of the polypeptides and relation to the Ig superfamilyQ36529311
J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowthQ36529831
Structure of a new nervous system glycoprotein, Nr-CAM, and its relationship to subgroups of neural cell adhesion moleculesQ36529926
Cell adhesion molecules: implications for a molecular histologyQ37285231
Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion moleculeQ37349829
Expression sequences of cell adhesion moleculesQ37551680
Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylationQ38334824
The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirusQ38341187
Mapping of three carbohydrate attachment sites in embryonic and adult forms of the neural cell adhesion moleculeQ38353319
Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-SepharoseQ39218339
Differential splicing and alternative polyadenylation generates distinct NCAM transcripts and proteins in the mouseQ41091409
The J1 glycoprotein--a novel nervous system cell adhesion molecule of the L2/HNK-1 familyQ41242730
Effects of fasciculation on the outgrowth of neurites from spinal ganglia in cultureQ41277916
Isolation and nucleotide sequence of mouse NCAM cDNA that codes for a Mr 79,000 polypeptide without a membrane-spanning regionQ41337679
Studies of adhesion molecules mediating interactions between cells of peripheral nervous system indicate a major role for L1 in mediating sensory neuron growth on Schwann cells in cultureQ41553757
Comparison of two cell surface molecules involved in neural cell adhesionQ41563674
The neural cell adhesion molecule L1 is distinct from the N-CAM related group of surface antigens BSP-2 and D2Q41566364
Neural cell adhesion molecule expression is regulated by Schwann cell-neuron interactions in cultureQ41577438
Neuronal process outgrowth of human sensory neurons on monolayers of cells transfected with cDNAs for five human N-CAM isoformsQ41583555
Adult and embryonic mouse neural cell adhesion molecules have different binding properties.Q41608343
Neurite outgrowth in response to transfected N-CAM and N-cadherin reveals fundamental differences in neuronal responsiveness to CAMsQ41696751
Recombinant peripheral myelin protein Po confers both adhesion and neurite outgrowth-promoting propertiesQ41717227
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2.Q41734593
Accumulation of N-CAM 180 at Contact Sites Between Neuroblastoma Cells and Latex Beads Coated with Extracellular Matrix MoleculesQ41748518
Functional cooperation between the neural adhesion molecules L1 and N-CAM is carbohydrate dependentQ41750582
Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion moleculeQ41818966
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glandsQ41922155
A threshold effect of the major isoforms of NCAM on neurite outgrowthQ42833491
The 180-kD component of the neural cell adhesion molecule N-CAM is involved in cell-cell contacts and cytoskeleton-membrane interactionsQ43588821
Neurite outgrowth patterns in cerebellar microexplant cultures are affected by antibodies to the cell surface glycoprotein L1.Q44587766
Neural cell adhesion molecules influence second messenger systemsQ44943537
Adhesion of neural cells to extracellular matrix constituents. Involvement of glycosaminoglycans and cell adhesion moleculesQ46078217
Release of the 120 kDa component of the mouse neural cell adhesion molecule N-CAM from cell surfaces by phosphatidylinositol-specific phospholipase C.Q48264087
Differentiation state-dependent surface mobilities of two forms of the neural cell adhesion molecule.Q48265750
Studies on the transmembrane disposition of the neural cell adhesion molecule N-CAM. A monoclonal antibody recognizing a cytoplasmic domain and evidence for the presence of phosphoserine residues.Q48646379
Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescenceQ48735182
Neural surface antigens during nervous system development.Q48828040
Cultivation of mouse cerebellar cells in serum free, hormonally defined media: survival of neuronsQ48967740
Expression of Thy-1, H-2 and NS-4 cell surface antigens and tetanus toxin receptors in early postnatal and adult mouse cerebellumQ49153092
Neural cell adhesion molecules and myelin-associated glycoprotein share a common carbohydrate moiety recognized by monoclonal antibodies L2 and HNK-1.Q52272634
Molecular heterogeneity and structural evolution during cerebellar ontogeny detected by monoclonal antibody of the mouse cell surface antigen BSP-2.Q52281696
Immunoelectron-microscopic localization of the 180 kD component of the neural cell adhesion molecule N-CAM in postsynaptic membranes.Q54104611
Differential inhibition of neurone-neurone, neurone-astrocyte and astrocyte-astrocyte adhesion by L1, L2 and N-CAM antibodies.Q54291110
Renaturation, purification and characterization of recombinant Fab-fragments produced in Escherichia coliQ54701477
Synthesis and characterization of extended and deleted recombinant analogues of parathyroid hormone-(1-84): correlation of peptide structure with function.Q54707084
Neural cell adhesion molecule is on embryonic muscle cells and mediates adhesion to nerve cells in vitroQ59070460
Antibodies to a neural cell adhesion molecule disrupt histogenesis in cultured chick retinaeQ59078365
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigensQ59092174
Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding siteQ67969096
Induction of neural cell adhesion molecule (NCAM) in Xenopus embryosQ68889640
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectcell adhesionQ187640
P304page(s)177-194
P577publication date1992-07-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleDifferent extracellular domains of the neural cell adhesion molecule (N-CAM) are involved in different functions
P478volume118

Reverse relations

cites work (P2860)
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Q44537820Altered expression of NCAM in hippocampus and cortex may underlie memory and learning deficits in rats with streptozotocin-induced diabetes mellitus
Q28292038CD9 of mouse brain is implicated in neurite outgrowth and cell migration in vitro and is associated with the alpha 6/beta 1 integrin and the neural adhesion molecule L1
Q36377653CRYP-2/cPTPRO is a neurite inhibitory repulsive guidance cue for retinal neurons in vitro
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Q42378304Exenatide Alters Gene Expression of Neural Cell Adhesion Molecule (NCAM), Intercellular Cell Adhesion Molecule (ICAM), and Vascular Cell Adhesion Molecule (VCAM) in the Hippocampus of Type 2 Diabetic Model Mice.
Q48409282Expression of protein zero is increased in lesioned axon pathways in the central nervous system of adult zebrafish
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