Mechanisms of ribosome stalling by SecM at multiple elongation steps

scientific article published on 14 December 2015

Mechanisms of ribosome stalling by SecM at multiple elongation steps is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.7554/ELIFE.09684
P8608Fatcat IDrelease_lau6thx2yvh4hcnjj2va7jvnmy
P932PMC publication ID4737659
P698PubMed publication ID26670735

P50authorSui SenfangQ9371527
Xijiang PanQ125324270
Ning GaoQ41600695
P2093author name stringJun Zhang
Shan Sun
Kaige Yan
P2860cites workStructures of the bacterial ribosome in classical and hybrid states of tRNA bindingQ24635922
Slow peptide bond formation by proline and other N-alkylamino acids in translationQ24646781
Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosomeQ24647686
MolProbity: all-atom structure validation for macromolecular crystallographyQ24649111
Ribosome regulation by the nascent peptideQ24650962
PHENIX: a comprehensive Python-based system for macromolecular structure solutionQ24654617
A primer to single-particle cryo-electron microscopyQ27322872
Crystal structure of a translation termination complex formed with release factor RF2Q27653093
Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysisQ27653327
The Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational StateQ27657797
Structural insight into nascent polypeptide chain-mediated translational stalling.Q27658309
Structural aspects of messenger RNA reading frame maintenance by the ribosomeQ27660608
Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide releaseQ27660905
Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug actionQ27664697
Structural basis for translational stalling by human cytomegalovirus and fungal arginine attenuator peptideQ27664949
The Mechanism for Activation of GTP Hydrolysis on the RibosomeQ27665613
Cryo-EM structure of the ribosome–SecYE complex in the membrane environmentQ27667539
Structural basis for potent inhibitory activity of the antibiotic tigecycline during protein synthesisQ27676529
Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM.Q27677990
Control of Ribosomal Subunit Rotation by Elongation Factor GQ27678849
Structure of the ribosome with elongation factor G trapped in the pretranslocation stateQ27680854
Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptideQ27682411
Structure of the Yeast Mitochondrial Large Ribosomal SubunitQ27682617
Initiation of Translation by Cricket Paralysis Virus IRES Requires Its Translocation in the RibosomeQ27683626
Structure of the Mammalian Ribosome-Sec61 Complex to 3.4 Å ResolutionQ27684332
Regulation of the Mammalian Elongation Cycle by Subunit Rolling: A Eukaryotic-Specific Ribosome RearrangementQ27684558
Architecture of the large subunit of the mammalian mitochondrial ribosomeQ27688018
The complete structure of the large subunit of the mammalian mitochondrial ribosomeQ27695673
Molecular basis for the ribosome functioning as an L-tryptophan sensorQ27695702
Structure of the 70S ribosome complexed with mRNA and tRNAQ27860602
UCSF Chimera--a visualization system for exploratory research and analysisQ27860666
Accurate determination of local defocus and specimen tilt in electron microscopyQ27861008
Refinement of macromolecular structures by the maximum-likelihood methodQ27861011
EMAN2: an extensible image processing suite for electron microscopyQ27861052
Features and development of CootQ27861079
Structure of the large ribosomal subunit from human mitochondria.Q28116177
Following the signal sequence from ribosomal tunnel exit to signal recognition particleQ28272496
RELION: implementation of a Bayesian approach to cryo-EM structure determinationQ29547673
The process of mRNA-tRNA translocationQ30480890
Secretion monitor, SecM, undergoes self-translation arrest in the cytosolQ31923120
SecA protein hydrolyzes ATP and is an essential component of the protein translocation ATPase of Escherichia coliQ33562047
Regulation of Escherichia coli secA by cellular protein secretion proficiency requires an intact gene X signal sequence and an active transloconQ33737540
SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase centerQ33803719
Upstream open reading frames as regulators of mRNA translationQ33966388
Ribosome. Mechanical force releases nascent chain-mediated ribosome arrest in vitro and in vivoQ42151283
A "push and slide" mechanism allows sequence-insensitive translocation of secretory proteins by the SecA ATPaseQ42209016
Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnelQ42406802
How the ribosome hands the A-site tRNA to the P site during EF-G-catalyzed translocationQ42745601
Structural insights into the roles of water and the 2' hydroxyl of the P site tRNA in the peptidyl transferase reactionQ46802328
SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.Q52513940
The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation.Q52930336
Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Q54463767
Genetically encoded but nonpolypeptide prolyl-tRNA functions in the A site for SecM-mediated ribosomal stall.Q54465004
Homogeneous stalled ribosome nascent chain complexes produced in vivo or in vitro.Q54478521
Combining Electron Microscopic with X-Ray Crystallographic StructuresQ63866208
Regulation of the Escherichia coli secA gene is mediated by two distinct RNA structural conformationsQ77742977
The ribosomal exit tunnel functions as a discriminating gateQ34118341
A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosomeQ34145335
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptideQ34148533
The mechanism of eukaryotic translation initiation: new insights and challengesQ34289214
Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulationQ34309801
Structural characterization of the complex of SecB and metallothionein-labeled proOmpA by cryo-electron microscopy.Q34442682
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA.Q34470091
The bacterial translation stress response.Q34490409
Elongation arrest by SecM via a cascade of ribosomal RNA rearrangementsQ34528562
Classification of Structural Heterogeneity by Maximum-Likelihood MethodsQ34831758
Single-Particle Cryo-EM at Crystallographic ResolutionQ35537724
Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stallingQ35579451
Mechanisms of SecM-mediated stalling in the ribosomeQ36105305
Fluctuations of transfer RNAs between classical and hybrid statesQ36129047
Identification of two distinct hybrid state intermediates on the ribosomeQ36462728
Translocon “Pulling” of Nascent SecM Controls the Duration of Its Translational Pause and Secretion-Responsive secA RegulationQ37051988
The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnelQ37245890
Programmed drug-dependent ribosome stallingQ37378026
Translational Regulation of Gene Expression during Conditions of Cell StressQ37802038
Nascent polypeptide sequences that influence ribosome functionQ37845977
Arrest peptides: cis-acting modulators of translation.Q38112828
Ribosome-targeting antibiotics and mechanisms of bacterial resistance.Q38171225
Tetracycline antibiotics and resistance mechanisms.Q38185338
The regulatory potential of upstream open reading frames in eukaryotic gene expressionQ38226318
How cryo-EM is revolutionizing structural biologyQ38301962
The catalytic cycle of the escherichia coli SecA ATPase comprises two distinct preprotein translocation eventsQ38339927
Dual regulation of Escherichia coli secA translation by distinct upstream elementsQ38349239
Multiple ways to regulate translation initiation in bacteria: Mechanisms, regulatory circuits, dynamics.Q38384774
Mechanisms of ribosome rescue in bacteriaQ38421473
Sequence-dependent elongation dynamics on macrolide-bound ribosomesQ39325572
Single-molecule imaging of full protein synthesis by immobilized ribosomesQ40640370
The dynamics of SecM-induced translational stallingQ40774135
Drug sensing by the ribosome induces translational arrest via active site perturbationQ41607219
Ribosome dynamics and tRNA movement by time-resolved electron cryomicroscopyQ41618424
High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopyQ42103385
P407language of work or nameEnglishQ1860
P577publication date2015-12-14
P1433published ineLifeQ2000008
P1476titleMechanisms of ribosome stalling by SecM at multiple elongation steps
P478volume4

Reverse relations

cites work (P2860)
Q47326437Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Q92631762Cotranslational Folding of Proteins on the Ribosome
Q64897374EF-G-induced ribosome sliding along the noncoding mRNA.
Q57050110Effects of protein size, thermodynamic stability, and net charge on cotranslational folding on the ribosome
Q89168645How Messenger RNA and Nascent Chain Sequences Regulate Translation Elongation
Q26750776How Widespread is Metabolite Sensing by Ribosome-Arresting Nascent Peptides?
Q47215849Identification and characterization of a translation arrest motif in VemP by systematic mutational analysis.
Q61446196Increased freedom of movement in the nascent chain results in dynamic changes in the structure of the SecM arrest motif
Q45160993Molecular insights into protein synthesis with proline residues.
Q92492317Nascent SecM chain interacts with outer ribosomal surface to stabilize translation arrest
Q92240573Reverse genetics-based biochemical studies of the ribosomal exit tunnel constriction region in eukaryotic ribosome stalling: spatial allocation of the regulatory nascent peptide at the constriction
Q90573494Ribosome collisions alter frameshifting at translational reprogramming motifs in bacterial mRNAs
Q33773452Ribosome rearrangements at the onset of translational bypassing
Q46316930SecA mediates cotranslational targeting and translocation of an inner membrane protein
Q100428013Selective inhibition of human translation termination by a drug-like compound
Q64983280Structural and mutational analysis of the ribosome-arresting human XBP1u.
Q92503277Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule
Q50900973The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel
Q41597754The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling
Q59874809The shape of the bacterial ribosome exit tunnel affects cotranslational protein folding.
Q42956873Translocation as continuous movement through the ribosome
Q91699011mRNA regions where 80S ribosomes pause during translation elongation in vivo interact with protein uS19, a component of the decoding site

Search more.