The immunologic functions of the neonatal Fc receptor for IgG

scientific article published on 5 September 2012

The immunologic functions of the neonatal Fc receptor for IgG is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1007/S10875-012-9768-Y
P932PMC publication ID3548031
P698PubMed publication ID22948741
P5875ResearchGate publication ID230797650

P2093author name stringEdda Fiebiger
Timo Rath
Masaru Yoshida
Richard S Blumberg
Kanna Kobayashi
Timothy T Kuo
Wayne I Lencer
Kristi Baker
Derry Roopenian
Shuo-Wang Qiao
P2860cites workA major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetusQ24337337
Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulinQ24645189
The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespanQ24673691
Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambsQ24682712
Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell ImmunityQ27489852
Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent bindingQ27631600
X-ray Crystal Structures of Monomeric and Dimeric Peptide Inhibitors in Complex with the Human Neonatal Fc Receptor, FcRnQ27662922
The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humansQ28208533
Neonatal Fc receptor and IgG-based therapeuticsQ28252134
An Fc receptor structurally related to MHC class I antigensQ28569860
Receptor-mediated transport of IgGQ30442369
The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarityQ30485266
Reduction of IgG in nonhuman primates by a peptide antagonist of the neonatal Fc receptor FcRnQ33319667
Effects of intravenous immunoglobulin on platelet count and antiplatelet antibody disposition in a rat model of immune thrombocytopenia.Q33343985
Intravenous immunoglobulin mediates an increase in anti-platelet antibody clearance via the FcRn receptor.Q33346093
Pharmacokinetic/pharmacodynamic modeling of the effects of intravenous immunoglobulin on the disposition of antiplatelet antibodies in a rat model of immune thrombocytopeniaQ33348131
Human CD141+ (BDCA-3)+ dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens.Q33902330
Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodiesQ34102657
Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptorQ34244234
Neonatal Fc receptor: from immunity to therapeuticsQ34268801
Visualizing the site and dynamics of IgG salvage by the MHC class I-related receptor, FcRn.Q34294972
Isolation from human placenta of the IgG transporter, FcRn, and localization to the syncytiotrophoblast: implications for maternal-fetal antibody transport.Q34402831
Transfer of IgG in the female genital tract by MHC class I-related neonatal Fc receptor (FcRn) confers protective immunity to vaginal infectionQ34693822
Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteriaQ34768249
Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cellsQ35049100
Divergent activities of an engineered antibody in murine and human systems have implications for therapeutic antibodiesQ35214746
Efficient mucosal vaccination mediated by the neonatal Fc receptor.Q35399345
Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport.Q35546930
Mechanisms of MHC class I-restricted antigen processing and cross-presentationQ36266466
Sedimentation equilibrium analysis of recombinant mouse FcRn with murine IgG1.Q52576953
The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin.Q53828120
A Theoretical Model of γ-Globulin CatabolismQ59081837
Isolation and characterization of an Fc receptor from neonatal rat small intestineQ70089834
Crystallization and stoichiometry of binding of a complex between a rat intestinal Fc receptor and FcQ70672540
Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient miceQ71012001
Localization of the site of the murine IgG1 molecule that is involved in binding to the murine intestinal Fc receptorQ72715944
Increased clearance of IgG in mice that lack beta 2-microglobulin: possible protective role of FcRnQ73027779
Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRnQ73046074
Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1Q73082065
The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugsQ73149177
Evidence to support the cellular mechanism involved in serum IgG homeostasis in humansQ78960971
Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockadeQ80088102
Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lungQ36370858
Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathwayQ36448851
Podocytes use FcRn to clear IgG from the glomerular basement membraneQ36458931
Pulmonary administration of therapeutic proteins using an immunoglobulin transport pathwayQ36602166
Mouse MHC class I-like Fc receptor encoded outside the MHC.Q36673236
Dependence of antibody-mediated presentation of antigen on FcRnQ36756942
An IgG-transporting Fc receptor expressed in the syncytiotrophoblast of human placentaQ36814851
FcRn: the neonatal Fc receptor comes of age.Q36912134
Conditional deletion of the MHC class I-related receptor FcRn reveals the sites of IgG homeostasis in miceQ37115251
Bidirectional transepithelial IgG transport by a strongly polarized basolateral membrane Fcgamma-receptor.Q37220781
Molecular engineering and design of therapeutic antibodiesQ37227301
Antigen presentation in celiac disease.Q37430981
An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice.Q37454723
Immune and non-immune functions of the (not so) neonatal Fc receptor, FcRn.Q37502056
The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptorQ37590654
Neonatal Fc receptor for IgG (FcRn) expressed in the gastric epithelium regulates bacterial infection in miceQ37661162
Intracellular mechanisms of antigen cross presentation in dendritic cellsQ37695674
The MHC class I-like Fc receptor promotes humorally mediated autoimmune diseaseQ37698818
Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseasesQ39632316
Enhanced antibody half-life improves in vivo activityQ40045495
Neonatal FcR expression in bone marrow-derived cells functions to protect serum IgG from catabolismQ40078990
Apical to basolateral transcytosis and apical recycling of immunoglobulin G in trophoblast-derived BeWo cells: effects of low temperature, nocodazole, and cytochalasin D.Q40778738
Expression of functionally active FcRn and the differentiated bidirectional transport of IgG in human placental endothelial cellsQ40826883
Cloning and characterization of the bovine MHC class I-like Fc receptorQ40902406
Stoichiometry of the interaction between the major histocompatibility complex-related Fc receptor and its Fc ligandQ41680426
The transmission of immune globulins from the mother to the foetal and newborn youngQ43643314
Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants.Q45023089
The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and releaseQ46077540
High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R.Q46117208
Crystal structure at 2.2 A resolution of the MHC-related neonatal Fc receptor.Q46478074
Ontogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestineQ46546664
Human neonatal Fc receptor mediates transport of IgG into luminal secretions for delivery of antigens to mucosal dendritic cells.Q47365627
The chicken yolk sac IgY receptor, a functional equivalent of the mammalian MHC-related Fc receptor, is a phospholipase A2 receptor homologQ47607389
Sequence and expression of the FcRn in the porcine mammary glandQ48259584
Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.Q51110501
Properties of human IgG1s engineered for enhanced binding to the neonatal Fc receptor (FcRn).Q51174776
An engineered human IgG1 antibody with longer serum half-life.Q51301844
Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.Q51348965
Delivery of an erythropoietin-Fc fusion protein by inhalation in humans through an immunoglobulin transport pathway.Q51350436
Albumin binding to FcRn: distinct from the FcRn-IgG interaction.Q51808620
Oral and pulmonary delivery of FSH-Fc fusion proteins via neonatal Fc receptor-mediated transcytosis.Q51818158
Expression of the Fc receptor in the mammary gland during lactation in the marsupial Trichosurus vulpecula (brushtail possum).Q52144468
P304page(s)S9-17
P577publication date2012-09-05
P1433published inJournal of Clinical ImmunologyQ6294961
P1476titleThe immunologic functions of the neonatal Fc receptor for IgG
P478volume33 Suppl 1

Reverse relations

cites work (P2860)
Q38292087Albumin and its application in drug delivery
Q90523456Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?
Q40237489An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum.
Q91808144Antibody Structure and Function: The Basis for Engineering Therapeutics
Q37689507Antigen cross-presentation of immune complexes
Q38217623Assessment of the metabolism of therapeutic proteins and antibodies
Q38257496CMV-encoded Fcγ receptors: modulators at the interface of innate and adaptive immunity
Q37138255Characterization of anti-CD20 monoclonal antibody produced by transgenic silkworms (Bombyx mori).
Q37079801Clinically significant anti-KEL RBC alloantibodies are transferred by breast milk in a murine model
Q37138959Cross-species analysis of Fc engineered anti-Lewis-Y human IgG1 variants in human neonatal receptor transgenic mice reveal importance of S254 and Y436 in binding human neonatal Fc receptor
Q35545292Defense-in-depth by mucosally administered anti-HIV dimeric IgA2 and systemic IgG1 mAbs: complete protection of rhesus monkeys from mucosal SHIV challenge
Q48294090Detection of ovomucoid-specific low-affinity IgE in infants and its relationship to eczema.
Q40007308Dosing regimens, FVIII levels and estimated haemostatic protection with special focus on rFVIIIFc.
Q36214076Engineered antibody domains with significantly increased transcytosis and half-life in macaques mediated by FcRn
Q34389202Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy
Q34937851Expression and function of the lipocalin-2 (24p3/NGAL) receptor in rodent and human intestinal epithelia
Q47844351FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells.
Q35670904FcRn: The Architect Behind the Immune and Nonimmune Functions of IgG and Albumin.
Q86332982Food allergens are transferred intact across the rat blood-placental barrier in vivo
Q45875104From IgG Fusion Proteins to Engineered-Specific Human Regulatory T Cells: A Life of Tolerance
Q47764097Hepatic function of FcRn revealed: Implications for overcoming drug-mediated hepatotoxicity.
Q47593242IgG Fc engineering to modulate antibody effector functions
Q26745000Immunoglobulin Transporting Receptors Are Potential Targets for the Immunity Enhancement and Generation of Mammary Gland Bioreactor
Q36131665Importance of the Side Chain at Position 296 of Antibody Fc in Interactions with FcγRIIIa and Other Fcγ Receptors
Q92372570Improved In Vitro Model for Intranasal Mucosal Drug Delivery: Primary Olfactory and Respiratory Epithelial Cells Compared with the Permanent Nasal Cell Line RPMI 2650
Q42428917Interspecies pharmacokinetic modeling of subcutaneous absorption of rituximab in mice and rats
Q37720658Intradermal delivery of Shigella IpaB and IpaD type III secretion proteins: kinetics of cell recruitment and antigen uptake, mucosal and systemic immunity, and protection across serotypes
Q90147338Maternal alloimmune IgG causes anti-glomerular basement membrane disease in perinatal transgenic mice that express human laminin α5
Q90364822Mouse fetal intestinal organoids: new model to study epithelial maturation from suckling to weaning
Q35866472Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants
Q51740195Neonatal Fc receptor is involved in the protection of fibrinogen after its intake in peripheral blood mononuclear cells.
Q90382714Neutralizing Monoclonal Antibodies Reduce Human Cytomegalovirus Infection and Spread in Developing Placentas
Q26738728Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues
Q93128162Passive immune transfer in puppies
Q92762054Plant-derived protein bodies as delivery vehicles for recombinant proteins into mammalian cells
Q38090391Progress toward inducing immunologic tolerance to factor VIII.
Q38593866Protective role of mouse IgG1 in cryoglobulinaemia; insights from an animal model and relevance to human pathology.
Q27321626Recombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A mice
Q45882083Reduction of Factor VIII Inhibitor Titers During Immune Tolerance Induction With Recombinant Factor VIII-Fc Fusion Protein
Q34818194Regulation of immune responses by the neonatal fc receptor and its therapeutic implications
Q35368495Systemically administered IgG anti-toxin antibodies protect the colonic mucosa during infection with Clostridium difficile in the piglet model
Q28080589Targeting FcRn for the modulation of antibody dynamics
Q35754853The Arp2/3 complex has essential roles in vesicle trafficking and transcytosis in the mammalian small intestine
Q50130439The Human Penis Is a Genuine Immunological Effector Site
Q93369828The Potential of Exosomes From Cow Milk for Oral Delivery
Q31162899The first thousand days - intestinal microbiology of early life: establishing a symbiosis.
Q28257521The neonatal Fc receptor, FcRn, as a target for drug delivery and therapy
Q33997395The role of Fc receptors in HIV infection and vaccine efficacy.
Q93052070Tolerating Factor VIII: Recent Progress
Q88194388Tolerogenic properties of the Fc portion of IgG and its relevance to the treatment and management of hemophilia
Q89620890Transmissible Gastroenteritis Virus Infection Up-Regulates FcRn Expression via Nucleocapsid Protein and Secretion of TGF-β in Porcine Intestinal Epithelial Cells
Q91871894Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1
Q47436060Tubular reabsorption of high, middle and low molecular weight proteins according to the tubulo-interstitial damage marker N-acetyl-β-D-glucosaminidase in glomerulonephritis

Search more.