E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter

scientific article published on 12 September 2015

E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.5128
P932PMC publication ID4741652
P698PubMed publication ID26397135
P5875ResearchGate publication ID282130931

P2093author name stringQiang Liu
Yinghua Zhu
Fengxi Su
Yujie Liu
Erwei Song
Lijuan Sun
Chang Gong
Xiaobin Lv
Bodu Liu
Junjun Chu
Yanqin Wu
Pengnan Hu
P2860cites workDNA-damage response control of E2F7 and E2F8Q24306816
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Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaQ24539231
MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1Q24648241
MiR-15 and miR-16 are direct transcriptional targets of E2F1 that limit E2F-induced proliferation by targeting cyclin EQ28117082
miR-15a and miR-16-1 in cancer: discovery, function and future perspectivesQ28247489
The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activitiesQ28297958
E2F7 represses a network of oscillating cell cycle genes to control S-phase progressionQ28592916
Cross-study validation and combined analysis of gene expression microarray dataQ31129354
Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifenQ33337206
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patientsQ33519584
Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancerQ33555064
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancerQ33933172
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survivalQ33939753
Oncogenic HER2Δ16 suppresses miR-15a/16 and deregulates BCL-2 to promote endocrine resistance of breast tumorsQ34363866
Clinical relevance of E2F family members in ovarian cancer--an evaluation in a training set of 77 patientsQ34597068
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Tamoxifen downregulation of miR-451 increases 14-3-3ζ and promotes breast cancer cell survival and endocrine resistance.Q35218111
MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cellsQ35643732
High miR-26a and low CDC2 levels associate with decreased EZH2 expression and with favorable outcome on tamoxifen in metastatic breast cancerQ36070061
Interaction of E2F7 transcription factor with E2F1 and C-terminal-binding protein (CtBP) provides a mechanism for E2F7-dependent transcription repressionQ37112680
MicroRNAs 15a and 16 regulate tumor proliferation in multiple myelomaQ37262390
Biological determinants of endocrine resistance in breast cancerQ37585095
Re-expression of microRNA-375 reverses both tamoxifen resistance and accompanying EMT-like properties in breast cancerQ39363790
E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formationQ39882791
E2F-6 suppresses growth-associated apoptosis of human hematopoietic progenitor cells by counteracting proapoptotic activity of E2F-1.Q40113861
Elevated levels of epidermal growth factor receptor/c-erbB2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant MCF-7 cellsQ40670668
Response-specific antiestrogen resistance in a newly characterized MCF-7 human breast cancer cell line resulting from long-term exposure to trans-hydroxytamoxifenQ41160149
Modulation of the growth-inhibitory effects of progestins and the antiestrogen hydroxyclomiphene on human breast cancer cells by epidermal growth factor and insulinQ41290624
Changes in apoptosis, mitosis, Her-2, p53 and Bcl2 expression in breast carcinomas after short-term tamoxifen treatment.Q44043956
Biomarker discovery in non-small cell lung cancer: integrating gene expression profiling, meta-analysis, and tissue microarray validation.Q44093400
Cyclin-E is a strong predictor of endocrine therapy failure in human breast cancer.Q44534514
The 2000 EBCTCG overview: a widening gap.Q44788235
Molecular changes in tamoxifen-resistant breast cancer: relationship between estrogen receptor, HER-2, and p38 mitogen-activated protein kinaseQ45309214
A graphical method for exploring heterogeneity in meta-analyses: application to a meta-analysis of 65 trials.Q52032770
The prognostic ease and difficulty of invasive breast carcinoma.Q53256620
microRNA-Associated Progression Pathways and Potential Therapeutic Targets Identified by Integrated mRNA and microRNA Expression Profiling in Breast CancerQ58211596
Epidermal-growth-factor receptors and oestrogen receptors in human breast cancerQ69856765
P433issue31
P407language of work or nameEnglishQ1860
P921main subjecttamoxifenQ412178
overexpressionQ61643320
P304page(s)31944-31957
P577publication date2015-09-12
P1433published inOncotargetQ1573155
P1476titleE2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter
P478volume6

Reverse relations

cites work (P2860)
Q49912442A Potential Prognostic Long Noncoding RNA Signature to Predict Recurrence among ER-positive Breast Cancer Patients Treated with Tamoxifen
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Q62785312ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors
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Q95642313SNHG7 Contributes to the Progression of Non-Small-Cell Lung Cancer via the SNHG7/miR-181a-5p/E2F7 Axis
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Q92191083Targeting Pin1 by All-Trans Retinoic Acid (ATRA) Overcomes Tamoxifen Resistance in Breast Cancer via Multifactorial Mechanisms
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Q36666943miR-16-5p Is a Stably-Expressed Housekeeping MicroRNA in Breast Cancer Tissues from Primary Tumors and from Metastatic Sites

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