Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis.

scientific article published on 28 September 2015

Repurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/ONCOTARGET.5422
P932PMC publication ID4741748
P698PubMed publication ID26426994

P50authorHan Yong ChoiQ85904531
P2093author name stringDo-Hyun Nam
Kyeung Min Joo
Hye Won Lee
Seong Soo Jeon
Byong Chang Jeong
Sharon Lim
Da Eun Jeong
Joung Eun Lim
Hye Jin Jin Song
Se Jeong Jeong Lee
P2860cites workVEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAPK/ERK and SAPK/JNK signalingQ22009049
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Current perspectives on the mechanism of action of artemisininsQ22061943
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Tumorigenesis and the angiogenic switchQ29619849
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Therapeutic effects of artesunate in hepatocellular carcinoma: repurposing an ancient antimalarial agentQ30834716
Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosisQ33384203
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Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivoQ33666019
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Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET.Q34217927
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous ironQ34344151
Dihydroartemisinin exerts its anticancer activity through depleting cellular iron via transferrin receptor-1.Q34382566
From mechanistic studies on artemisinin derivatives to new modular antimalarial drugsQ34568416
Morphological and biochemical aspects of apoptosis, oncosis and necrosisQ34797912
Metastatic renal cell carcinomaQ35206797
Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drugQ35585226
The role of calpain in oncotic cell deathQ35639152
Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious diseaseQ35741510
Vascular endothelial growth factor and angiogenesisQ35985850
Tumor angiogenesis and therapyQ36409381
Dihydroartemisinin induces autophagy and inhibits the growth of iron-loaded human myeloid leukemia K562 cells via ROS toxicityQ36811863
Anticancer properties of artemisinin derivatives and their targeted delivery by transferrin conjugationQ36973937
Cancer cells survive with survivinQ37185505
Enhancing the cytotoxic activity of novel targeted therapies--is there a role for a combinatorial approach?Q37239233
Transcription-independent functions of MYC: regulation of translation and DNA replicationQ37242438
Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancers dependent on the epidermal growth factor receptor pathway.Q37379113
Novel therapeutic inhibitors of the c-Met signaling pathway in cancerQ37422804
Anticancer activities of artemisinin and its bioactive derivativesQ37626137
Effects of artesunate on cytokinesis and G₂/M cell cycle progression of tumour cells and budding yeast.Q38338694
Anticancer Effect of AntiMalarial Artemisinin CompoundsQ38414908
The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancerQ38948059
Alpha-smooth muscle actin (ACTA2) is required for metastatic potential of human lung adenocarcinomaQ39101536
Tpl2 kinase impacts tumor growth and metastasis of clear cell renal cell carcinoma.Q39104237
Artesunate inhibits the growth of gastric cancer cells through the mechanism of promoting oncosis both in vitro and in vivoQ39108206
Artesunate exerts specific cytotoxicity in retinoblastoma cells via CD71.Q39131904
Disulfiram, a drug widely used to control alcoholism, suppresses the self-renewal of glioblastoma and over-rides resistance to temozolomideQ39263561
A HIF-regulated VHL-PTP1B-Src signaling axis identifies a therapeutic target in renal cell carcinomaQ39532016
Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell linesQ39809835
Combination treatment of malignant B cells using the anti-CD20 antibody rituximab and the anti-malarial artesunateQ39840163
The role of downstream signaling pathways of the epidermal growth factor receptor for Artesunate's activity in cancer cells.Q39886511
High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptorQ39901668
Artesunate derived from traditional Chinese medicine induces DNA damage and repair.Q39976238
Dihydroartemisinin induces apoptosis in HL-60 leukemia cells dependent of iron and p38 mitogen-activated protein kinase activation but independent of reactive oxygen speciesQ39991619
Sorafenib (BAY 43-9006, Nexavar), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculatureQ40270911
Microarray expression profiles of angiogenesis-related genes predict tumor cell response to artemisinins.Q40325894
Combination treatment of glioblastoma multiforme cell lines with the anti-malarial artesunate and the epidermal growth factor receptor tyrosine kinase inhibitor OSI-774.Q40567286
Rapid responses to oxidative stress mediated by iron regulatory protein.Q40807123
Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosisQ41115305
The pathways of cell death: oncosis, apoptosis, and necrosisQ41376310
Metastatic patterns of renal carcinoma: an analysis of 687 necropsiesQ41407886
First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteasesQ43128296
Epidermal growth factor receptor protein expression and genomic alterations in renal cell carcinomaQ43407740
Ischemia leads to apoptosis--and necrosis-like neuron death in the ischemic rat hippocampus.Q45191529
Dihydroartemisinin induces apoptosis in human leukemia cells HL60 via downregulation of transferrin receptor expressionQ45329566
Dihydroartemisinin is an inhibitor of ovarian cancer cell growthQ47776445
Expression of HGF/SF and Met protein is associated with genetic alterations of VHL gene in primary renal cell carcinomas.Q53668779
Renal-Cell CarcinomaQ56019528
Graded ATP depletion can cause necrosis or apoptosis of cultured mouse proximal tubular cellsQ74255134
ATP-dependent steps in apoptotic signal transductionQ77415615
Artesunate attenuates the growth of human colorectal carcinoma and inhibits hyperactive Wnt/beta-catenin pathwayQ80372653
Artesunate inhibits angiogenesis and downregulates vascular endothelial growth factor expression in chronic myeloid leukemia K562 cellsQ80506793
P4510describes a project that usesImageJQ1659584
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectmalariaQ12156
artesunateQ707939
renal cell carcinomaQ1164529
metastatic renal cell carcinomaQ19000948
P304page(s)33046-33064
P577publication date2015-10-01
P1433published inOncotargetQ1573155
P1476titleRepurposing the anti-malarial drug artesunate as a novel therapeutic agent for metastatic renal cell carcinoma due to its attenuation of tumor growth, metastasis, and angiogenesis
P478volume6

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