Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells

scientific article published on April 1996

Raf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MCB.16.4.1458
P932PMC publication ID231130
P698PubMed publication ID8657119

P2093author name stringM R Rosner
M Yan
M Abe
J Rhee
M McMahon
S A McCarthy
D J Templeton
W L Kuo
E M Eves
P2860cites workAcetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activityQ24309185
Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoformsQ24312029
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factorQ24561804
Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirusQ24595462
MAP kinase pathways in yeast: for mating and moreQ27938176
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1Q28114883
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activationQ28301118
MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivoQ29615244
Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cellsQ29618480
Transformation of mammalian cells by constitutively active MAP kinase kinaseQ29618686
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKKQ29620274
Inhibition of platelet-derived growth factor- and epidermal growth factor-mediated mitogenesis and signaling in 3T3 cells expressing delta Raf-1:ER, an estradiol-regulated form of Raf-1.Q30450197
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinaseQ30450248
The interaction of SV40 small tumor antigen with protein phosphatase 2A stimulates the map kinase pathway and induces cell proliferation.Q34345750
A simple assay for DNA transfection by incubation of the cells in culture dishes with substrates for beta-galactosidaseQ35235268
The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transductionQ36332163
Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiationQ36552522
Immortal rat hippocampal cell lines exhibit neuronal and glial lineages and neurotrophin gene expressionQ37005628
Mitogen-activated protein kinase activation resulting from selective oncogene expression in NIH 3T3 and rat 1a cellsQ37146635
Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapkQ37370076
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.Q38292576
Conditional immortalization of neuronal cells from postmitotic cultures and adult CNS.Q41442613
Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.Q41481208
Activation of Mitogen‐Activated Protein Kinase by Epidermal Growth Factor in Hippocampal Neurons and Neuronal Cell LinesQ41525625
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSKQ41634356
Regulation of Insulin Degradation: Expression of an Evolutionarily Conserved Insulin-Degrading Enzyme Increases Degradation via an Intracellular PathwayQ41663137
Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathwaysQ42065880
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitroQ42510291
Activation of MAP kinases by calcium-dependent and calcium-independent pathways. Stimulation by thapsigargin and epidermal growth factorQ46488713
Sarcoma viruses carrying ras oncogenes induce differentiation-associated properties in a neuronal cell lineQ59094087
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiationQ70104566
Induction of neurite outgrowth by MAP kinase in PC12 cellsQ71928286
Deletion of a conserved juxtamembrane sequence in Trk abolishes NGF-promoted neuritogenesisQ71988401
Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinaseQ72068689
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptorQ72787935
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1458-1470
P577publication date1996-04-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleRaf, but not MEK or ERK, is sufficient for differentiation of hippocampal neuronal cells
P478volume16

Reverse relations

cites work (P2860)
Q39732365A Raf-1 mutant that dissociates MEK/extracellular signal-regulated kinase activation from malignant transformation and differentiation but not proliferation.
Q47595039A Raf-induced, MEK-independent signaling pathway regulates atrial natriuretic factor gene expression in cardiac muscle cells
Q33967754A novel mitogen-activated protein kinase is responsive to Raf and mediates growth factor specificity
Q48337718A potential role of Ras-mediated signal transduction for the enhancement of depolarization-induced Ca2+ responses in hippocampal neurons by basic fibroblast growth factor
Q43772807AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation
Q37376990Activated Raf-1 causes growth arrest in human small cell lung cancer cells
Q40928369Activation of mitogen-activated protein kinase is necessary but not sufficient for proliferation of human thyroid epithelial cells induced by mutant Ras.
Q40676937Activation of protein kinase A induces neuronal differentiation of HiB5 hippocampal progenitor cells
Q33995467Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line
Q47741881Analysis of signaling protein kinases in human colon or colorectal carcinomas
Q43559806Basic fibroblast growth factor-induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells
Q44642050Bruton's tyrosine kinase phosphorylates cAMP-responsive element-binding protein at serine 133 during neuronal differentiation in immortalized hippocampal progenitor cells
Q33638611Cellular aspects of trophic actions in the nervous system.
Q40725030Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation
Q41330986Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15.
Q33964695Different protein kinase C isoforms determine growth factor specificity in neuronal cells
Q74601694Differential activation by cytokines of mitogen-activated protein kinases in bovine temporomandibular-joint disc cells
Q40781024Differential activation of phospholipases by mitogenic EGF and neurogenic PDGF in immortalized hippocampal stem cell lines
Q42528763Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways
Q43284370Differentiation and neural integration of hippocampal neuronal progenitors: signaling pathways sequentially involved
Q36570448Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src
Q33219481Differentiation of neuroblastoma cell line N1E-115 involves several signaling cascades
Q40983049Estrogen activates raf-1 kinase and induces expression of Egr-1 in MCF-7 breast cancer cells
Q48287209Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways.
Q40992007Expression of immediate early gene cyr61 during the differentiation of immortalized embryonic hippocampal neuronal cells
Q28568168Extracellular signal-regulated kinase 7 (ERK7), a novel ERK with a C-terminal domain that regulates its activity, its cellular localization, and cell growth
Q40764401Glucocorticoid inhibits growth factor-induced differentiation of hippocampal progenitor HiB5 cells
Q31506480Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells.
Q28580565JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation
Q40605915LIM kinase 1 activates cAMP-responsive element-binding protein during the neuronal differentiation of immortalized hippocampal progenitor cells
Q28362229MEK kinase activity is not necessary for Raf-1 function
Q46563635Maternal dietary 22 : 6n-3 is more effective than 18 : 3n-3 in increasing the 22 : 6n-3 content in phospholipids of glial cells from neonatal rat brain
Q24532168Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
Q22008636Molecular cloning and characterization of a mitogen-activated protein kinase-associated intracellular chloride channel
Q24312115Nuclear Raf-1 kinase regulates the CXCR5 promoter by associating with NFATc3 to drive retinoic acid-induced leukemic cell differentiation
Q40793671Pairing of forskolin and KCl increases differentiation of immortalized hippocampal neurons in a CREB Serine 133 phosphorylation-dependent and extracellular-regulated protein kinase-independent manner
Q39356638Phospholipase D1 is an important regulator of bFGF-induced neurotrophin-3 expression and neurite outgrowth in H19-7 cells
Q48026353Progress toward understanding the molecular mechanisms of neurotrophic factor signalling
Q33652139Protein kinase Cdelta mediates neurogenic but not mitogenic activation of mitogen-activated protein kinase in neuronal cells
Q51964234Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.
Q33996268Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways
Q28565091Raf kinase inhibitory protein regulates Raf-1 but not B-Raf kinase activation
Q28581195Raf-1 and B-Raf proteins have similar regional distributions but differential subcellular localization in adult rat brain
Q40963599Raf-1 causes growth suppression and alteration of neuroendocrine markers in DMS53 human small-cell lung cancer cells
Q24633458Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK-ERK independent mechanism
Q33622872Raf-1 signaling is required for the later stages of 1,25-dihydroxyvitamin D3-induced differentiation of HL60 cells but is not mediated by the MEK/ERK module
Q41978120Regulation of cellular proliferation, differentiation and cell death by activated Raf.
Q36573600Role of cyclins in neuronal differentiation of immortalized hippocampal cells
Q41382912Signal transduction by the neurotrophin receptors
Q48291310Studying signal transduction in neuronal cells: the Trk/NGF system
Q28585285The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells
Q47823131The RAF family: an expanding network of post-translational controls and protein-protein interactions.
Q42835325Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation
Q33646179Vitamin D and differentiation in cancer
Q40209568Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3beta signaling
Q29994681cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells.
Q41671454p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation