Lipoprotein-associated phospholipase A2: pathogenic mechanisms and clinical utility for predicting cardiovascular events

scientific article published on September 2006

Lipoprotein-associated phospholipase A2: pathogenic mechanisms and clinical utility for predicting cardiovascular events is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1007/S11883-006-0034-8
P698PubMed publication ID16901407

P50authorChristie M. BallantyneQ98665268
P2093author name stringVijay Nambi
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Role of lipoprotein-associated phospholipase A2 in atherosclerosis and its potential as a therapeutic targetQ36403910
Lipoprotein-associated phospholipase A2 predicts future cardiovascular events in patients with coronary heart disease independently of traditional risk factors, markers of inflammation, renal function, and hemodynamic stressQ40332526
Lipoprotein-associated phospholipase A2 adds to risk prediction of incident coronary events by C-reactive protein in apparently healthy middle-aged men from the general population: results from the 14-year follow-up of a large cohort from southern GQ40479587
A prospective evaluation of lipoprotein-associated phospholipase A(2) levels and the risk of future cardiovascular events in womenQ40678229
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Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitorQ42992999
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Inhibition of lipoprotein-associated phospholipase A2 diminishes the death-inducing effects of oxidised LDL on human monocyte-macrophages.Q43750480
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Atorvastatin preferentially reduces LDL-associated platelet-activating factor acetylhydrolase activity in dyslipidemias of type IIA and type IIB.Q43880589
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Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cells. Relationship with electronegative LDL.Q45142360
Impaired binding affinity of electronegative low-density lipoprotein (LDL) to the LDL receptor is related to nonesterified fatty acids and lysophosphatidylcholine contentQ45185008
Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-upQ45200533
Lipoprotein-associated phospholipase A2 activity is associated with risk of coronary heart disease and ischemic stroke: the Rotterdam StudyQ45256250
Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscleQ45856333
LDL- is a lipid hydroperoxide-enriched circulating lipoprotein.Q46430533
Effects of atorvastatin versus other statins on fasting and postprandial C-reactive protein and lipoprotein-associated phospholipase A2 in patients with coronary heart disease versus control subjectsQ46447584
Lack of association between carotid intima-media thickness and PAF-acetylhydrolase mass and activity in patients with primary hyperlipidemia.Q46634215
Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).Q46745439
Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident ischemic stroke in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) studyQ46825104
Lipoprotein-associated phospholipase A2 and measures of extracoronary atherosclerosis: the Rotterdam StudyQ46864783
Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (PRavastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial InfarQ46990506
Plasma PAF acetylhydrolase in non-insulin dependent diabetes mellitus and obesity: effect of hyperinsulinemia and lovastatin treatment.Q51571771
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L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.Q53749030
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Molecular Basis of the Interaction between Plasma Platelet-activating Factor Acetylhydrolase and Low Density LipoproteinQ63579199
Platelet-Activating Factor Acetylhydrolase Is Mainly Associated With Electronegative Low-Density Lipoprotein SubfractionQ64355663
Platelet-activating factor acetylhydrolase increases during macrophage differentiation. A novel mechanism that regulates accumulation of platelet-activating factorQ69612982
Human platelets release a paf-acether: acetylhydrolase similar to that in plasmaQ70638656
Lysophosphatidylcholine stimulates the expression and production of MCP-1 by human vascular endothelial cellsQ71061251
A cytotoxic electronegative LDL subfraction is present in human plasmaQ71101450
PAF-degrading acetylhydrolase is preferentially associated with dense LDL and VHDL-1 in human plasma. Catalytic characteristics and relation to the monocyte-derived enzymeQ71799184
Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease. West of Scotland Coronary Prevention Study GroupQ73088406
Isolation, Characterization, and Functional Assessment of Oxidatively Modified Subfractions of Circulating Low-Density LipoproteinsQ73256291
Plasma PAF-acetylhydrolase in patients with coronary artery disease: results of a cross-sectional analysisQ73350111
Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery diseaseQ73901926
Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japanQ74080872
Altered activities of anti-atherogenic enzymes LCAT, paraoxonase, and platelet-activating factor acetylhydrolase in atherosclerosis-susceptible miceQ77763890
Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasmaQ78056182
Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemiaQ93607967
P433issue5
P304page(s)374-381
P577publication date2006-09-01
P1433published inCurrent Atherosclerosis ReportsQ20821076
P1476titleLipoprotein-associated phospholipase A2: pathogenic mechanisms and clinical utility for predicting cardiovascular events
P478volume8

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cites work (P2860)
Q37285933Lipoprotein(a): a promising marker for residual cardiovascular risk assessment
Q37738359Recent developments with lipoprotein-associated phospholipase A2 inhibitors
Q37690826Role of secretory phospholipase A₂ in women with metabolic syndrome
Q36945209The role of lipoprotein-associated phospholipase A2 as a marker for atherosclerosis

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