Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms.

scientific article published on January 2016

Nitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2741/4425
P932PMC publication ID4748372
P698PubMed publication ID26709810

P50authorLuis VillacortaQ42428596
P2093author name stringY Eugene Chen
Bruce A Freeman
Zhen Gao
Francisco J Schopfer
P2860cites workmiR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1Q83034995
Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo.Q50774975
Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation.Q51763432
The nitrated fatty acid 10-nitro-oleate attenuates allergic airway disease.Q53095793
Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons.Q53832347
PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory PropertiesQ57244208
Hypoxia Inducible Factor–Dependent Regulation of Angiogenesis by Nitro–Fatty AcidsQ59754259
Reactive oxygen species in human health and diseaseQ73590209
Evaluation of nitroalkenes as nitric oxide donorsQ79707306
Modulation of nitrated lipid signaling by multidrug resistance protein 1 (MRP1): glutathione conjugation and MRP1-mediated efflux inhibit nitrolinoleic acid-induced, PPARgamma-dependent transcription activationQ79752009
Increased protein nitration burden in the atherosclerotic lesions and plasma of apolipoprotein A-I deficient miceQ80576638
Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.Q24606271
Impact of soluble epoxide hydrolase and epoxyeicosanoids on human healthQ24618018
Inflammation, immunity, and hypertensive end-organ damageQ26827525
Molecular recognition of nitrated fatty acids by PPARγQ27651047
Redox-dependent anti-inflammatory signaling actions of unsaturated fatty acidsQ28386488
Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolaseQ28387540
The electrophile responsive proteome: integrating proteomics and lipidomics with cellular functionQ28388959
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxideQ29547245
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistanceQ29614354
Convergence of nitric oxide and lipid signaling: anti-inflammatory nitro-fatty acids.Q30374785
Nitrated fatty acids: Endogenous anti-inflammatory signaling mediatorsQ30480974
Nitro-oleic acid downregulates lipoprotein-associated phospholipase A2 expression via the p42/p44 MAPK and NFκB pathwaysQ33585468
Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammationQ33632763
Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids.Q33639171
Nitrate and nitrite in biology, nutrition and therapeuticsQ33685139
Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics.Q33702016
Nitro-oleic acid protects against endotoxin-induced endotoxemia and multiorgan injury in miceQ33727789
Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartmentQ33746493
Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and anti-diabetic signaling actionsQ33782620
Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.Q33803709
Inflammation and its resolution as determinants of acute coronary syndromesQ33834800
Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligandQ33849597
Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertensionQ33881508
Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male ratsQ33890925
Inflammation and immunity in the pathogenesis of pulmonary arterial hypertensionQ33898213
Nitrite treatment rescues cardiac dysfunction in aged mice treated with conjugated linoleic acidQ33938970
Platelets and their chemokines in atherosclerosis-clinical applicationsQ34019069
Effects of Endogenous PPAR Agonist Nitro-Oleic Acid on Metabolic Syndrome in Obese Zucker RatsQ34021895
Nitroalkenes confer acute cardioprotection via adenine nucleotide translocase 1.Q34096582
A cell-based phenotypic assay to identify cardioprotective agentsQ34186419
Macrophages in atherosclerosis: a dynamic balance.Q34368005
Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activityQ34414890
Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophagesQ34512881
Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statinsQ34522097
Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expressionQ34573108
Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2.Q34787024
Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanismQ34800018
Electrophilic fatty acids regulate matrix metalloproteinase activity and expression.Q34963415
Detection and quantification of protein adduction by electrophilic fatty acids: mitochondrial generation of fatty acid nitroalkene derivatives.Q35129775
Disruption of PPARγ/β-catenin-mediated regulation of apelin impairs BMP-induced mouse and human pulmonary arterial EC survivalQ35187029
Novel proresolving aspirin-triggered DHA pathwayQ35189668
Nitrooleic acid protects against cisplatin nephropathy: role of COX-2/mPGES-1/PGE2 cascadeQ35227002
Nitrooleic Acid Attenuates Lipid Metabolic Disorders and Liver Steatosis in DOCA-Salt Hypertensive Mice.Q35227098
Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome.Q35354138
Emerging biology of sphingosine-1-phosphate: its role in pathogenesis and therapyQ35535621
Convergence of biological nitration and nitrosation via symmetrical nitrous anhydrideQ35756214
Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleateQ35791844
Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel diseaseQ35791848
Formation and signaling actions of electrophilic lipidsQ35804051
Nitro-oleic acid targets transient receptor potential (TRP) channels in capsaicin sensitive afferent nerves of rat urinary bladderQ35906650
Generation and esterification of electrophilic fatty acid nitroalkenes in triacylglyceridesQ36190263
Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reactionQ36316709
Nitro-linoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathwayQ36319949
Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages.Q36339484
Regio- and stereospecific syntheses and nitric oxide donor properties of (E)-9- and (E)-10-nitrooctadec-9-enoic acidsQ36347304
Conjugated linoleic acid is a preferential substrate for fatty acid nitrationQ36492744
Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligandsQ36493003
Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts.Q36687046
Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.Q36796547
Characterization and quantification of endogenous fatty acid nitroalkene metabolites in human urine.Q36920628
Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injuryQ36956739
Modulation of nitro-fatty acid signaling: prostaglandin reductase-1 is a nitroalkene reductaseQ37132192
Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotectionQ37176170
PPARgamma and its ligands: therapeutic implications in cardiovascular disease.Q37179467
Co-treatment with conjugated linoleic acid and nitrite protects against myocardial infarctionQ37392069
Discovery of the nitric oxide signaling pathway and targets for drug developmentQ37409901
Cardiovascular consequences when nitric oxide and lipid signaling convergeQ37412845
Combined losartan and nitro-oleic acid remarkably improves diabetic nephropathy in miceQ37439729
Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acidQ37446099
Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusionQ37467857
Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesityQ37591231
Down-regulated peroxisome proliferator-activated receptor γ (PPARγ) in lung epithelial cells promotes a PPARγ agonist-reversible proinflammatory phenotype in chronic obstructive pulmonary disease (COPD).Q37622525
Mitochondrially targeted nitro-linoleate: a new tool for the study of cardioprotectionQ37686281
Novel aspects of dietary nitrate and human healthQ38103950
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytesQ38129182
Dynamic Aspects of Macrophage Polarization during Atherosclerosis Progression and RegressionQ38271958
Comparative efficacy and safety of blood pressure-lowering agents in adults with diabetes and kidney disease: a network meta-analysisQ38502138
Cardio-Pulmonary-Renal Interactions: A Multidisciplinary ApproachQ38517250
Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapyQ39645977
PPARs and lipid ligands in inflammation and metabolismQ41763780
Nitro-fatty acid metabolome: saturation, desaturation, beta-oxidation, and protein adductionQ41995295
Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductaseQ42020038
Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injuryQ42027780
Nitro-oleic acid inhibits angiotensin II-induced hypertensionQ42428542
Nrf2 protects against maladaptive cardiac responses to hemodynamic stressQ42456759
Nitro-oleic acid is a novel anti-oxidative therapy for diabetic kidney diseaseQ42756932
Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.Q43826766
The absence of macrophage Nrf2 promotes early atherogenesisQ43901244
Characterization of linoleic acid nitration in human blood plasma by mass spectrometry.Q44108232
Nitrolinoleate inhibits superoxide generation, degranulation, and integrin expression by human neutrophils: novel antiinflammatory properties of nitric oxide-derived reactive species in vascular cellsQ44128021
Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteinsQ44499494
Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.Q45985589
Specific GC-MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC-MS/MS reportsQ46151364
Fatty acid transduction of nitric oxide signaling. Nitrolinoleic acid is a hydrophobically stabilized nitric oxide donorQ46375494
6-Methylnitroarachidonate: a novel esterified nitroalkene that potently inhibits platelet aggregation and exerts cGMP-mediated vascular relaxationQ46383370
Nitrated lipids decompose to nitric oxide and lipid radicals and cause vasorelaxationQ46617979
Profiling and relative quantification of multiply nitrated and oxidized fatty acidsQ46722547
P921main subjectfatty acidQ61476
P304page(s)873-889
P577publication date2016-01-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleNitro-fatty acids in cardiovascular regulation and diseases: characteristics and molecular mechanisms
P478volume21

Reverse relations

cites work (P2860)
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Q52631728Inflammatory signaling and metabolic regulation by nitro-fatty acids.
Q55692383Multidirectional Efficacy of Biologically Active Nitro Compounds Included in Medicines.
Q39011349Nitro-fatty acids in plant signaling: New key mediators of nitric oxide metabolism
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Q97531874Suppression of Vascular Macrophage Activation by Nitro-Oleic Acid and its Implication for Abdominal Aortic Aneurysm Therapy
Q87858871Transcriptomic sequencing reveals diverse adaptive gene expression responses of human vascular smooth muscle cells to nitro-conjugated linoleic acid

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