The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains

scientific article published on June 1997

The signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.17.6.3021
P932PMC publication ID232154
P698PubMed publication ID9154800

P2093author name stringK Brown
U Siebenlist
Y C Lin
L Baldi
G Franzoso
L Carlson
L Mills
S Gerstberger
P2860cites workI kappa B/MAD-3 masks the nuclear localization signal of NF-kappa B p65 and requires the transactivation domain to inhibit NF-kappa B p65 DNA bindingQ24307786
The NF-kappa B and I kappa B proteins: new discoveries and insightsQ24313579
Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activationQ24316905
NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathwayQ24321670
Phosphorylation of human I kappa B-alpha on serines 32 and 36 controls I kappa B-alpha proteolysis and NF-kappa B activation in response to diverse stimuliQ24568220
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa BQ24568234
A novel mitogen-inducible gene product related to p50/p105-NF-kappa B participates in transactivation through a kappa B siteQ24630534
Mapping of the inducible IkappaB phosphorylation sites that signal its ubiquitination and degradationQ24650561
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose platesQ27860715
Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDaQ27861105
The candidate oncoprotein Bcl-3 is an antagonist of p50/NF-kappa B-mediated inhibitionQ28155838
The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimersQ28267241
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activityQ28276063
How proteolysis drives the cell cycleQ28297983
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinaseQ28567939
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathwayQ28615591
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitinationQ28615601
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathwayQ28615706
Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alphaQ28618972
Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activationQ28776205
Signal-induced degradation of I(kappa)B(alpha): association with NF-kappaB and the PEST sequence in I(kappa)B(alpha) are not requiredQ28776784
Amino acid sequences common to rapidly degraded proteins: the PEST hypothesisQ29547538
Function and activation of NF-kappa B in the immune systemQ29547790
Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylationQ29614709
Characterization of an immediate-early gene induced in adherent monocytes that encodes IκB-like activityQ29618284
Structure, regulation and function of NF-kappa BQ29620225
Constitutive phosphorylation of I kappa B alpha by casein kinase IIQ33994452
The oncoprotein Bcl-3 can facilitate NF-kappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites.Q34061332
The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle controlQ34205242
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa BQ34305414
Intramolecular masking of the nuclear location signal and dimerization domain in the precursor for the p50 NF-kappa B subunitQ34357628
Highly inducible expression from vectors containing multiple GRE's in CHO cells overexpressing the glucocorticoid receptorQ35232514
Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alphaQ36180990
N- and C-terminal sequences control degradation of MAD3/I kappa B alpha in response to inducers of NF-kappa B activityQ36555088
Phosphorylation of IkappaBalpha in the C-terminal PEST domain by casein kinase II affects intrinsic protein stabilityQ36557754
Constitutive phosphorylation of IkappaBalpha by casein kinase II occurs preferentially at serine 293: requirement for degradation of free IkappaBalphaQ36560731
Lipopolysaccharide induces phosphorylation of MAD3 and activation of c-Rel and related NF-kappa B proteins in human monocytic THP-1 cells.Q38318544
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retentionQ38325326
Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65.Q40016049
Casein kinase II phosphorylates I kappa B alpha at S-283, S-289, S-293, and T-291 and is required for its degradationQ40018293
Both amino- and carboxyl-terminal sequences within I kappa B alpha regulate its inducible degradationQ40018360
Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivoQ41078859
Identification of lysine residues required for signal-induced ubiquitination and degradation of I kappa B-alpha in vivoQ41192799
Regulation of V(D)J recombination activator protein RAG-2 by phosphorylationQ41553827
Role of IkappaBalpha ubiquitination in signal-induced activation of NFkappaB in vivoQ47070611
The ankyrin repeats but not the PEST-like sequences are required for signal-dependent degradation of IkappaBalphaQ71124125
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)3021-3027
P577publication date1997-06-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleThe signal response of IkappaB alpha is regulated by transferable N- and C-terminal domains
P478volume17

Reverse relations

cites work (P2860)
Q24644412A new member of the I kappaB protein family, I kappaB epsilon, inhibits RelA (p65)-mediated NF-kappaB transcription
Q40964581A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity
Q35604264A three-part signal governs differential processing of Gli1 and Gli3 proteins by the proteasome
Q40634789Cytoplasmic IkappaBalpha increases NF-kappaB-independent transcription through binding to histone deacetylase (HDAC) 1 and HDAC3.
Q42487466Degradation of cyclin D3 independent of Thr-283 phosphorylation
Q34421516FBI-1 enhances transcription of the nuclear factor-kappaB (NF-kappaB)-responsive E-selectin gene by nuclear localization of the p65 subunit of NF-kappaB.
Q38321481Identification by in vivo genomic footprinting of a transcriptional switch containing NF-kappaB and Sp1 that regulates the IkappaBalpha promoter
Q22010066Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor
Q28282499Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaB
Q38327988IkappaB-alpha enhances transactivation by the HOXB7 homeodomain-containing protein
Q39549729IkappaB-mediated inhibition of virus-induced beta interferon transcription
Q74358809Inducible expression of IkappaBalpha repressor mutants interferes with NF-kappaB activity and HIV-1 replication in Jurkat T cells
Q24514760Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription
Q57083000Molecular cloning and characterisation of a homologue of the alpha inhibitor of NF-κB in the griffon vulture (Gyps fulvus)
Q23923136New insights into the role of nuclear factor-KB, a ubiquitous transcription factor in the initiation of diseases
Q39977321Pre-folding IkappaBalpha alters control of NF-kappaB signaling
Q28216113Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB
Q34182208Regulation of constitutive p50/c-Rel activity via proteasome inhibitor-resistant IkappaBalpha degradation in B cells.
Q38337239Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.
Q33876994The PEST domain of IkappaBalpha is necessary and sufficient for in vitro degradation by mu-calpain
Q74516762The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha
Q38295947The role of constitutive NF-kappaB activity in PC-3 human prostate cancer cell invasive behavior
Q33962550c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

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