Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome

scientific article published on 21 January 2013

Genetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID3560480
P698PubMed publication ID23390562

P50authorRuijin ShaoQ61866148
P2093author name stringXin Li
Yi Feng
P2860cites workPolycystic Ovary SyndromeQ56092373
Changes in ovarian morphology and serum hormones in the rat after treatment with dehydroepiandrosteroneQ67905021
Mechanism by which 17β-Estradiol Inhibits Ovarian Androgen Production in the Rat*Q72878855
An increased intraovarian synthesis of nerve growth factor and its low affinity receptor is a principal component of steroid-induced polycystic ovary in the ratQ73500693
Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the ratQ73500695
The plasminogen activator system in women with polycystic ovary syndromeQ74296167
Transgenic models to study gonadotropin function: the role of follicle-stimulating hormone in gonadal growth and tumorigenesisQ77915030
Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patientsQ80445882
Polycystic ovary syndromeQ80844876
Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypesQ28504877
Follicle stimulating hormone is required for ovarian follicle maturation but not male fertilityQ28586787
Theca-specific estrogen receptor-alpha knockout mice lose fertility prematurelyQ30435277
Current concepts in the polycystic ovary syndromeQ31842930
Regulation of ovarian follicle atresiaQ34419879
Targeted overexpression of luteinizing hormone in transgenic mice leads to infertility, polycystic ovaries, and ovarian tumors.Q34607225
Increased adipose tissue in male and female estrogen receptor-alpha knockout miceQ35823619
Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor geneQ36692660
Molecular basis of aromatase deficiency in an adult female with sexual infantilism and polycystic ovariesQ36720508
Follicle dynamics and anovulation in polycystic ovary syndromeQ37171507
Excessive ovarian production of nerve growth factor facilitates development of cystic ovarian morphology in mice and is a feature of polycystic ovarian syndrome in humansQ37210806
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force reportQ37308058
The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysisQ38354867
Estrogen Treatment of Immature Rats Inhibits Ovarian Androgen Production in Vitro*Q40223432
Effects of a single injection of estradiol valerate on the hypothalamic arcuate nucleus and on reproductive function in the female ratQ41941213
The plasminogen activator system in young and lean women with polycystic ovary syndromeQ42164960
Development of the polycystic ovarian condition (PCO) in the estradiol valerate-treated rat.Q42511587
Involvement of nitric oxide and the ovarian blood follicle barrier in murine follicular cyst developmentQ44245869
Is plasminogen activator inhibitor-1 a cardiovascular risk factor in young women with polycystic ovary syndrome?Q44289368
Overexpression of human chorionic gonadotropin causes multiple reproductive defects in transgenic mice.Q44388595
Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndromeQ45050569
The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteriaQ45081416
Changes with age in aromatization of testosterone in immature female ratsQ45265694
Plasminogen activator inhibitor-1 4G/5G and 5,10-methylene-tetrahydrofolate reductase C677T polymorphisms in polycystic ovary syndromeQ46208583
Luteinizing hormone receptor, steroidogenesis acute regulatory protein, and steroidogenic enzyme messenger ribonucleic acids are overexpressed in thecal and granulosa cells from polycystic ovariesQ46394991
Gonadal defects and hormonal alterations in transgenic mice expressing a single chain human chorionic gonadotropin-lutropin receptor complexQ46430512
Insights into hypothalamic-pituitary dysfunction in polycystic ovary syndromeQ48326902
Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropinQ48484416
An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) geneQ48887422
Prevention of the polycystic ovarian phenotype and characterization of ovulatory capacity in the estrogen receptor-alpha knockout mouseQ48905112
Ambulatory blood pressure profiles and plasminogen activator inhibitor (PAI-1) activity in lean women with and without the polycystic ovary syndrome.Q51578585
Transgenic overexpression of plasminogen activator inhibitor-1 promotes the development of polycystic ovarian changes in female mice.Q51748145
A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.Q51753660
Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult.Q52176898
Elevated luteinizing hormone in prepubertal transgenic mice causes hyperandrogenemia, precocious puberty, and substantial ovarian pathology.Q53966288
Phenotype and genotype in polycystic ovary syndrome.Q54121622
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectpolycystic ovaryQ5547896
polycystic ovary syndromeQ500816
P304page(s)15-20
P577publication date2013-01-21
P1433published inAmerican Journal of Translational ResearchQ4744272
P1476titleGenetic modeling of ovarian phenotypes in mice for the study of human polycystic ovary syndrome
P478volume5

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Q47809993Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle developmentcites workP2860

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