Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice

scientific article published on 10 April 2008

Topical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2353/AJPATH.2008.071117
P932PMC publication ID2329834
P698PubMed publication ID18403589
P5875ResearchGate publication ID5448265

P50authorBarbara GilchrestQ93373562
P2093author name stringErvin H Epstein
David A Goukassian
Jennifer Hebert
Edoardo Zattra
Simin Arad
P2860cites workMammalian telomeres end in a large duplex loopQ22009893
Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS responseQ24646197
8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesisQ28262204
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosisQ28288534
Altered neural cell fates and medulloblastoma in mouse patched mutantsQ28588056
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
Cancer. p53, guardian of the genomeQ29615610
DNA oligonucleotide treatment corrects the age-associated decline in DNA repair capacityQ30829157
Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cellsQ30908342
Ultraviolet B(UVB)-induced cox-2 expression in murine skin: an immunohistochemical studyQ31856494
Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cellsQ33616030
T-loop assembly in vitro involves binding of TRF2 near the 3' telomeric overhangQ34082359
The epidemiology of UV induced skin cancerQ34421835
Evidence that exposure of the telomere 3' overhang sequence induces senescenceQ34470102
A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinomaQ34982679
Molecular and cellular biology of basal cell carcinoma.Q34992500
Telomeric DNA induces apoptosis and senescence of human breast carcinoma cellsQ35749321
DNA repair and aging in basal cell carcinoma: a molecular epidemiology studyQ36118189
The tale of the telomere: implications for prevention and treatment of skin cancersQ36346181
Long-term health risk to the skin of ultraviolet radiationQ36449905
The mechanics of base excision repair, and its relationship to aging and diseaseQ36656724
Novel Hedgehog pathway targets against basal cell carcinomaQ36727507
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.Q37095361
DNA damage enhances melanogenesisQ37730186
T-oligo treatment decreases constitutive and UVB-induced COX-2 levels through p53- and NFkappaB-dependent repression of the COX-2 promoterQ38323145
Nevoid basal-cell carcinoma syndromeQ39759038
Features that determine telomere homolog oligonucleotide-induced therapeutic DNA damage-like responses in cancer cellsQ40203284
Cyclooxygenase-2 overexpression in human basal cell carcinoma cell line increases antiapoptosis, angiogenesis, and tumorigenesis.Q40306645
Telomere-based DNA damage responses: a new approach to melanomaQ40521591
Mechanisms of DNA excision repairQ40556396
Inhibition of cyclooxygenase-2 gene expression by p53.Q40962096
Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout miceQ41699926
Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndromeQ42455110
Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient miceQ42457002
Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiationQ42464066
UV dose determines key characteristics of nonmelanoma skin cancer.Q42471830
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomasQ42473020
Immunophenotypic analysis of the p53 gene in non-melanoma skin cancer and correlation with apoptosis and cell proliferationQ42475230
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibitionQ42478216
Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss.Q42496571
UV-specific p53 and PTCH mutations in sporadic basal cell carcinoma of sun-exposed skin.Q42499255
Relationship between sunlight exposure and a key genetic alteration in basal cell carcinomaQ42516318
Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approachesQ42523881
8-hydroxy-2'-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposureQ42525634
Telomere 3' overhang-specific DNA oligonucleotides induce autophagy in malignant glioma cellsQ48193623
T-oligos augment UV-induced protective responses in human skin.Q53608224
DNA damage and melanogenesisQ60071776
Thymidine dinucleotide mimics the effect of solar simulated irradiation on p53 and p53-regulated proteinsQ77787151
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)1248-1255
P577publication date2008-04-10
P1433published inThe American Journal of PathologyQ4744259
P1476titleTopical thymidine dinucleotide treatment reduces development of ultraviolet-induced basal cell carcinoma in Ptch-1+/- mice
P478volume172

Reverse relations

cites work (P2860)
Q597987575-Aminolevulinic Acid-Based Photodynamic Therapy Pretreatment Mitigates Ultraviolet A-Induced Oxidative Photodamage
Q46524661A bio-mimetic approach to DNA photoprotection
Q34066208Actinic keratosis treatment as a key component of preventive strategies for nonmelanoma skin cancer
Q35687900Basal cell carcinomas: attack of the hedgehog
Q38520163Chemopreventive opportunities to control basal cell carcinoma: Current perspectives
Q37795414Critical Review of Preclinical Approaches to Evaluate the Potential of Immunosuppressive Drugs to Influence Human Neoplasia
Q28387971Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin
Q38639628Establishment of basal cell carcinoma animal model in Chinese tree shrew (Tupaia belangeri chinensis).
Q37957565Molecular aspects of tanning
Q37775962Novel investigational drugs for basal cell carcinoma
Q34467172Oral Feeding of Pomegranate Fruit Extract Inhibits Early Biomarkers of UVB Radiation‐induced Carcinogenesis in SKH‐1 Hairless Mouse Epidermis
Q42513961Radiotherapy-induced basal cell carcinomas of the scalp: are they genetically different?
Q85360811Telomere-Based Protective Responses to DNA Damage
Q37579017Telomere-mediated effects on melanogenesis and skin aging
Q38348975Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage
Q42325589Topical application of thymidine dinucleotide to newborn mice reduces and delays development of UV-induced melanomas
Q34135616Topical delivery of DNA oligonucleotide to induce p53 generation in the skin via thymidine dinucleotide (pTT)-encapsulated liposomal carrier

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