Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14

scientific article published on 29 November 2012

Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14 is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.AJPATH.2012.10.014
P932PMC publication ID3562736
P698PubMed publication ID23201091
P5875ResearchGate publication ID233827399

P2093author name stringRana Al-Sadi
Thomas Y Ma
Hamid M Said
Shuhong Guo
P2860cites workMeasurement of endotoxin activity in critically ill patients using whole blood neutrophil dependent chemiluminescenceQ24801390
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanismQ28568715
Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel diseaseQ28586834
Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responsesQ28910463
Intestinal mucosal barrier function in health and diseaseQ29618086
Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cellsQ31107759
Pure endotoxin does not pass across the intestinal epithelium in vitro.Q32046948
Ferulaldehyde, a water-soluble degradation product of polyphenols, inhibits the lipopolysaccharide-induced inflammatory response in mice.Q33395586
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivoQ34014510
Endotoxin levels correlate positively with a sedentary lifestyle and negatively with highly trained subjectsQ34068261
Analysis of the effects of lipopolysaccharide on macrophages: differential phagocytic responses of C3H/HeN and C3H/HeJ macrophages in vitroQ34088739
Inflammatory bowel disease and adenomas in mice expressing a dominant negative N-cadherinQ34290465
Endotoxemia: methods of detection and clinical correlatesQ34300796
Mechanism of interferon-gamma-induced increase in T84 intestinal epithelial tight junctionQ34334200
Significance of systemic endotoxaemia in inflammatory bowel diseaseQ34408149
TLR signaling in the gut in health and diseaseQ34409408
Endotoxaemia in active Crohn's disease. Treatment with whole gut irrigation and 5-aminosalicylic acidQ34529897
Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrierQ35057031
The dynamics of LPS recognition: complex orchestration of multiple receptorsQ36096351
MicroRNA regulation of intestinal epithelial tight junction permeabilityQ37047074
Human endotoxemia as a model of systemic inflammationQ37232921
Stress-induced gastrointestinal barrier dysfunction and its inflammatory effectsQ37268618
Intestinal barrier dysfunction, endotoxemia, and gastrointestinal symptoms: the 'canary in the coal mine' during exercise-heat stress?Q37390256
Necrotizing enterocolitis: an updateQ37868171
Paeoniflorin protects RAW 264.7 macrophages from LPS-induced cytotoxicity and genotoxicityQ39835583
Host species-specific usage of the TLR4-LPS receptor complex.Q39955478
Treponemal glycoconjugate inhibits Toll‐like receptor ligand‐induced cell activation by blocking LPS‐binding protein and CD14 functionsQ40622903
Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipidsQ40860922
Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouseQ41122462
Changes in intestinal mucosal immune barrier in rats with endotoxemiaQ41887735
Enteric lipopolysaccharide raises plasma IL-6 levels in the hepatoportal vein during non-inflammatory stress in the rat.Q42520988
Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion.Q43921108
Endotoxaemia in exhausted runners after a long-distance raceQ44393643
The mechanisms of prednisone inhibition of inflammation in Crohn's disease involve changes in intestinal permeability, mucosal TNFalpha production and nuclear factor kappa B expressionQ44535156
TNF-alpha-induced increase in intestinal epithelial tight junction permeability requires NF-kappa B activationQ44758263
Early gut mucosal dysfunction in patients with acute pancreatitisQ45416100
Energy intake is associated with endotoxemia in apparently healthy men.Q45769895
Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitisQ46339936
The critical role of toll-like receptor (TLR) 4 in alcoholic liver disease is independent of the common TLR adapter MyD88.Q46367336
Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cellsQ46403001
SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism?Q46783993
Localization of endotoxin in the rat intestinal epitheliumQ50119789
Probiotic mixture VSL#3 protects the epithelial barrier by maintaining tight junction protein expression and preventing apoptosis in a murine model of colitis.Q50454240
Intestinal barrier failure during experimental necrotizing enterocolitis: protective effect of EGF treatment.Q52571670
TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor MoleculesQ52603956
Early increase in intestinal permeability in patients with severe acute pancreatitis: correlation with endotoxemia, organ failure, and mortality.Q52865134
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function.Q55052541
Serum lipopolysaccharide-binding protein in endotoxemic patients with inflammatory bowel diseaseQ57774227
Strenuous exercise causes systemic endotoxemiaQ68468515
Intestinal permeability and the prediction of relapse in Crohn's diseaseQ72220492
The interaction of human peripheral blood eosinophils with bacterial lipopolysaccharide is CD14 dependentQ73335984
Riboflavin uptake by human-derived colonic epithelial NCM460 cellsQ73426616
Leaky gut in alcoholic cirrhosis: a possible mechanism for alcohol-induced liver damageQ77957963
Therapeutic effects of erythropoietin in murine models of endotoxin shockQ83391817
P433issue2
P407language of work or nameEnglishQ1860
P921main subjecttoll-like receptorQ408004
lipopolysaccharideQ421804
P304page(s)375-387
P577publication date2012-11-29
P1433published inThe American Journal of PathologyQ4744259
P1476titleLipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14
P478volume182

Reverse relations

cites work (P2860)
Q90195014(10Z)-Debromohymenialdisine from Marine Sponge Stylissa sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells
Q47163293A New Proposal for the Pathogenic Mechanism of Non-Coeliac/Non-Allergic Gluten/Wheat Sensitivity: Piecing Together the Puzzle of Recent Scientific Evidence
Q35615534A Selected Lactobacillus rhamnosus Strain Promotes EGFR-Independent Akt Activation in an Enterotoxigenic Escherichia coli K88-Infected IPEC-J2 Cell Model
Q37278774A novel approach to maintain gut mucosal integrity using an oral enzyme supplement.
Q41567299AMP-activated protein kinase: a therapeutic target in intestinal diseases.
Q90266551Altered nutrient status reprograms host inflammation and metabolic health via gut microbiota
Q90133544Animal Models of Undernutrition and Enteropathy as Tools for Assessment of Nutritional Intervention
Q64876812Anti-Tumor Necrosis Factor Therapy and Incidence of Parkinson Disease Among Patients With Inflammatory Bowel Disease
Q39036198Association Between Exercise-Induced Hyperthermia and Intestinal Permeability: A Systematic Review.
Q37629699Association of CD14/-260 polymorphism with gastric cancer risk in Highland Tibetans
Q42682689Atopic dermatitis and the intestinal microbiota in humans and dogs
Q95840233Baicalin prevents LPS-induced activation of TLR4/NF-κB p65 pathway and inflammation in mice via inhibiting the expression of CD14
Q52661962Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis.
Q89792879CD14 and ALPK1 Affect Expression of Tight Junction Components and Proinflammatory Mediators upon Bacterial Stimulation in a Colonic 3D Organoid Model
Q64890153Caecal infusion of the short-chain fatty acid propionate affects the microbiota and expression of inflammatory cytokines in the colon in a fistula pig model.
Q51471088Characterization of tight junction disruption and immune response modulation in a miniaturized Caco-2/U937 coculture-based in vitro model of the human intestinal barrier.
Q35683371Chemotherapy-driven dysbiosis in the intestinal microbiome.
Q41854099Chronic exposure to indoxacarb and pulmonary expression of toll-like receptor-9 in mice
Q55068125Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function.
Q35755435Comorbidity between depression and inflammatory bowel disease explained by immune-inflammatory, oxidative, and nitrosative stress; tryptophan catabolite; and gut-brain pathways
Q89835386Correlation between Antibodies to Bacterial Lipopolysaccharides and Barrier Proteins in Sera Positive for ASCA and ANCA
Q35104722Dai Huang Fu Zi Tang could ameliorate intestinal injury in a rat model of hemorrhagic shock by regulating intestinal blood flow and intestinal expression of p-VASP and ZO-1.
Q35447220Delivery of berberine using chitosan/fucoidan-taurine conjugate nanoparticles for treatment of defective intestinal epithelial tight junction barrier.
Q51843281Development of a chicken ileal explant culture model for measurement of gut inflammation induced by lipopolysaccharide.
Q40495815Development of an in vitro co-culture model to mimic the human intestine in healthy and diseased state
Q40340991Dietary fibre-based SCFA mixtures promote both protection and repair of intestinal epithelial barrier function in a Caco-2 cell model.
Q57100701Dietary l-threonine supplementation attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage of broiler chickens at an early age
Q36212472Differential effect of early antibiotic intervention on bacterial fermentation patterns and mucosal gene expression in the colon of pigs under diets with different protein levels
Q58697318Distribution and Neurochemistry of the Porcine Ileocaecal Valve Projecting Sensory Neurons in the Dorsal Root Ganglia and the Influence of Lipopolysaccharide from Different Serotypes of spp. on the Chemical Coding of DRG Neurons in the Cell Cultures
Q90643005Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney disease
Q52688162Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis.
Q90814981Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans
Q28821251Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome
Q40102664Enterotoxigenic Escherichia coli and probiotics in swine: what the bleep do we know?
Q89901094Epithelial Toll-like receptors and their role in gut homeostasis and disease
Q50088048FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
Q92658502Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats
Q47342337Functional sequencing read annotation for high precision microbiome analysis
Q36010414Gastrointestinal and hepatic mechanisms limiting entry and dissemination of lipopolysaccharide into the systemic circulation
Q50579605Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice.
Q38785087Green tea polyphenol epigallocatechin-3-gallate improves epithelial barrier function by inducing the production of antimicrobial peptide pBD-1 and pBD-2 in monolayers of porcine intestinal epithelial IPEC-J2 cells.
Q37452229Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis
Q55120679Gut Dysbiosis and Muscle Aging: Searching for Novel Targets against Sarcopenia.
Q47180560Gut Microbiota Contribute to Age-Related Changes in Skeletal Muscle Size, Composition, and Function: Biological Basis for a Gut-Muscle Axis
Q92209913Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD)
Q41334746Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis
Q40738118Hematopoietic plakophilin-3 regulates acute tissue-specific and systemic inflammation in mice
Q47174382High-Altitude-Induced alterations in Gut-Immune Axis: A review
Q90304410High-fat diet-induced alterations to gut microbiota and gut-derived lipoteichoic acid contributes to the development of enteric neuropathy
Q47642289High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine.
Q61812813Higher Fecal Short-Chain Fatty Acid Levels Are Associated with Gut Microbiome Dysbiosis, Obesity, Hypertension and Cardiometabolic Disease Risk Factors
Q91708332Identifying Microbiota Signature and Functional Rules Associated With Bacterial Subtypes in Human Intestine
Q64880411Impaired tissue barriers as potential therapeutic targets for Parkinson's disease and amyotrophic lateral sclerosis
Q91713907In Vitro Entero-Capillary Barrier Exhibits Altered Inflammatory and Exosomal Communication Pattern after Exposure to Silica Nanoparticles
Q92932269Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling
Q42516812Inhibition of intestinal ascorbic acid uptake by lipopolysaccharide is mediated via transcriptional mechanism(s).
Q92494838Innate immunity in allergy
Q38698979Integrated gut/liver microphysiological systems elucidates inflammatory inter-tissue crosstalk.
Q39828924Intestinal Alkaline Phosphatase Regulates Tight Junction Protein Levels
Q38584691Intestinal epithelial barrier function and tight junction proteins with heat and exercise
Q34438743Intestinal inflammation and mucosal barrier function
Q90304266Intestinal microbiome-macrophage crosstalk contributes to cholestatic liver disease by promoting intestinal permeability
Q64261314Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage
Q38735352LPS Induces Hyper-Permeability of Intestinal Epithelial Cells
Q39417780Lactobacillus sakei K17, an inducer of IL-10 expression in antigen-presenting cells, attenuates TNBS-induced colitis in mice
Q64934343Linking the gut and liver: crosstalk between regulatory T cells and mucosa-associated invariant T cells.
Q36260383Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88.
Q40975183Lipopolysaccharide Upregulated Intestinal Epithelial Cell Expression of Fn14 and Activation of Fn14 Signaling Amplify Intestinal TLR4-Mediated Inflammation
Q42379913Lipopolysaccharide from Crypt-Specific Core Microbiota Modulates the Colonic Epithelial Proliferation-to-Differentiation Balance
Q91649573Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice
Q38722967Lipopolysaccharide inhibits colonic biotin uptake via interference with membrane expression of its transporter: a role for a casein kinase 2-mediated pathway
Q47382531Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
Q90447905MMP-9-induced increase in intestinal epithelial tight permeability is mediated by p38 kinase signaling pathway activation of MLCK gene
Q51277396Maternal vitamin D beneficially programs metabolic, gut and bone health of mouse male offspring in an obesogenic environment.
Q38235918Mechanisms of tissue injury in autoimmune liver diseases
Q58774497Mechanisms regulating intestinal barrier integrity and its pathological implications
Q37497781Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Q39363389Microbiome and NAFLD: potential influence of aerobic fitness and lifestyle modification
Q90745434Microbiota and Other Preventive Strategies and Non-genetic Risk Factors in Parkinson's Disease
Q99710953Modeling undernutrition with enteropathy in mice
Q35579440Monosodium L-glutamate and dietary fat exert opposite effects on the proximal and distal intestinal health in growing pigs
Q62675748Myalgic encephalomyelitis or chronic fatigue syndrome: how could the illness develop?
Q57283707Non-alcoholic fatty liver disease and obesity: the role of the gut bacteria
Q48010938Oat β-glucan inhibits lipopolysaccharide-induced nonalcoholic steatohepatitis in mice
Q36647390Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice
Q64067887Oxidative Stress in the Poultry Gut: Potential Challenges and Interventions
Q33572623Pathogenesis and clinical spectrum of primary sclerosing cholangitis
Q27015831Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management
Q37268441Pathophysiological mechanisms of diarrhea caused by the Vibrio cholerae O1 El Tor variant: an in vivo study in mice.
Q42374059Perinatal Bisphenol A Exposure Induces Chronic Inflammation in Rabbit Offspring via Modulation of Gut Bacteria and Their Metabolites
Q37293093Plasmadiafiltration ameliorating gut mucosal barrier dysfunction and improving survival in porcine sepsis models
Q90636691Potential of Omega-3 Polyunsaturated Fatty Acids in Managing Chemotherapy- or Radiotherapy-Related Intestinal Microbial Dysbiosis
Q35779264Potential role of gut microbiota and tissue barriers in Parkinson's disease and amyotrophic lateral sclerosis
Q41087764Preinduction of heat shock protein 70 protects mice against post-infection irritable bowel syndrome via NF-κB and NOS/NO signaling pathways
Q47856590Protective Effect of 1,25-Dihydroxy Vitamin D3 on Pepsin-Trypsin-Resistant Gliadin-Induced Tight Junction Injuries
Q85855195Protective effect of 1,25-dihydroxyvitamin d3 on lipopolysaccharide-induced intestinal epithelial tight junction injury in caco-2 cell monolayers
Q52926235Protective effect of hydrogen sulfide on TNF-α and IFN-γ-induced injury of intestinal epithelial barrier function in Caco-2 monolayers.
Q86912426Protective effect of simvastatin on impaired intestine tight junction protein ZO-1 in a mouse model of Parkinson's disease
Q90707790Protective effects of vitamin D against injury in intestinal epithelium
Q46215190Purification and Anti-pathogenic Properties of Immunoglobulin Concentrates from Porcine Blood
Q58570126Re-purposing 16S rRNA gene sequence data from within case paired tumor biopsy and tumor-adjacent biopsy or fecal samples to identify microbial markers for colorectal cancer
Q95840413Recent advances of sterile inflammation and inter-organ cross-talk in alcoholic liver disease
Q92092838Reduced Proprotein convertase subtilisin/kexin 9 (PCSK9) function increases lipoteichoic acid clearance and improves outcomes in Gram positive septic shock patients
Q34731373Reduction of endotoxin attenuates liver fibrosis through suppression of hepatic stellate cell activation and remission of intestinal permeability in a rat non-alcoholic steatohepatitis model.
Q90258100Regulation of TLR4 in silica-induced inflammation: An underlying mechanism of silicosis
Q64113253Role of Gut Microbiota in the Pharmacological Effects of Natural Products
Q39886548STAT5A Modulates Chemokine Receptor CCR6 Expression and Enhances Pre-B Cell Growth in a CCL20-Dependent Manner
Q37012940Safety concerns over the use of intestinal permeation enhancers: A mini-review
Q50974955Sequence and functional analysis of intestinal alkaline phosphatase from Lateolabrax maculatus.
Q41979804Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans
Q49953574Succinylated chitosan derivative has local protective effects on intestinal inflammation.
Q90722749The Effects and Mechanisms of Cyanidin-3-Glucoside and Its Phenolic Metabolites in Maintaining Intestinal Integrity
Q40849359The Effects of Glucagon-like Peptide-2 on the Tight Junction and Barrier Function in IPEC-J2 Cells through Phosphatidylinositol 3-kinase-Protein Kinase B-Mammalian Target of Rapamycin Signaling Pathway
Q38944057The Potential Role of Gut-Derived Inflammation in Multiple System Atrophy.
Q53688070The Protective Mechanism of CAY10683 on Intestinal Mucosal Barrier in Acute Liver Failure through LPS/TLR4/MyD88 Pathway.
Q37683531The Role of Intestinal Alkaline Phosphatase in Inflammatory Disorders of Gastrointestinal Tract.
Q40258168The effect of omega- 3 polyunsaturated fatty acids on endothelial tight junction occludin expression in rat aorta during lipopolysaccharide-induced inflammation
Q35610662The intestinal barrier in irritable bowel syndrome: subtype-specific effects of the systemic compartment in an in vitro model
Q31141977The intricate association between gut microbiota and development of type 1, type 2 and type 3 diabetes
Q89624002The role of the gut microbiome in chronic liver disease: the clinical evidence revised
Q42353639The role of the intestinal microvasculature in inflammatory bowel disease: studies with a modified Caco-2 model including endothelial cells resembling the intestinal barrier in vitro
Q59812465Ulvan Activates Chicken Heterophils and Monocytes Through Toll-Like Receptor 2 and Toll-Like Receptor 4
Q61443105Urogenital schistosomiasis is associated with signatures of microbiome dysbiosis in Nigerian adolescents
Q52679056Xyloglucan, a Plant Polymer with Barrier Protective Properties over the Mucous Membranes: An Overview.

Search more.