G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids

scientific article published on 16 December 2015

G-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids is …
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scholarly articleQ13442814

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P356DOI10.1097/ALN.0000000000000984
P932PMC publication ID4755838
P698PubMed publication ID26675532

P50authorKevin WickmanQ42229309
P2093author name stringJun Ren
Nicole C Victoria
John J Greer
Gaspard Montandon
Richard L Horner
Hattie Liu
P2860cites workPre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in MammalsQ24630958
Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neuronsQ24658250
Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2Q24672204
5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesiaQ28186606
Ampakines alleviate respiratory depression in ratsQ28263792
Molecular mechanisms mediating inhibition of G protein-coupled inwardly-rectifying K+ channelsQ30310709
Normal breathing requires preBötzinger complex neurokinin-1 receptor-expressing neurons.Q33606313
Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBötzinger complex.Q33609200
Sleep-disordered breathing after targeted ablation of preBötzinger complex neuronsQ33640899
Targeting GIRK Channels for the Development of New Therapeutic AgentsQ34068551
Incidence, Reversal, and Prevention of Opioid-induced Respiratory DepressionQ34088079
Two different inward rectifier K+ channels are effectors for transmitter-induced slow excitation in brain neuronsQ34394636
Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease.Q34643934
GIRK channel modulation by assembly with allosterically regulated RGS proteinsQ36471320
Pain-facilitating medullary neurons contribute to opioid-induced respiratory depressionQ36533232
Pontine μ-opioid receptors mediate bradypnea caused by intravenous remifentanil infusions at clinically relevant concentrations in dogsQ36533279
Management of opioid analgesic overdoseQ37084008
The evolving understanding of the analgesic mechanism of action of flupirtineQ37813146
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Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generationQ38971517
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine.Q39424563
Medication-assisted therapies--tackling the opioid-overdose epidemicQ42218151
NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors.Q42511409
G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons.Q44012210
CrossTalk proposal: The preBotzinger complex is essential for the respiratory depression following systemic administration of opioid analgesicsQ44343923
cAMP-dependent reversal of opioid- and prostaglandin-mediated depression of the isolated respiratory network in newborn ratsQ44347118
PreBotzinger complex neurokinin-1 receptor-expressing neurons mediate opioid-induced respiratory depressionQ44349196
Reversal of opioid-induced respiratory depression by BK-channel blocker GAL021: A pharmacokinetic-pharmacodynamic modeling study in healthy volunteersQ44349836
Patterns of abuse among unintentional pharmaceutical overdose fatalitiesQ44745614
Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia.Q44804066
D1-dopamine receptor agonists prevent and reverse opiate depression of breathing but not antinociception in the cat.Q45261268
Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain.Q46432836
RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area.Q46927228
State-dependent contribution of the hyperpolarization-activated Na+/K+ and persistent Na+ currents to respiratory rhythmogenesis in vivoQ48008062
Respiratory depression with opioidsQ80150659
Signaling complexes of voltage-gated calcium channels and G protein-coupled receptorsQ81155064
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)641-650
P577publication date2015-12-16
P1433published inAnesthesiologyQ2012635
P1476titleG-protein-gated Inwardly Rectifying Potassium Channels Modulate Respiratory Depression by Opioids
P478volume124

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