Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells

scientific article published on 4 December 2012

Vitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1152/AJPENDO.00359.2012
P932PMC publication ID3566509
P698PubMed publication ID23211517
P5875ResearchGate publication ID233848396

P50authorTimothy J. GarrettQ67228598
P2093author name stringMei Zhao
Jesse F Gregory
S Jill James
Maria A Ralat
Vanessa da Silva
Stephan Melnyk
P2860cites workThe Effect of Vitamin B-6 Deficiency on the Fatty Acid Composition of the Major Phospholipids in the RatQ67436027
Effect of pyridoxine deficiency on phospholipid methylation in rat liver microsomesQ69575915
Accumulation of linoleic and gamma-linolenic acids in tissue lipids of pyridoxine-deficient ratsQ70622817
Effect of Vitamin B6 Deficiency on Tissue Dehydrogenases and Fat Synthesis in RatsQ71750204
Measurement of plasma and intracellular S-adenosylmethionine and S-adenosylhomocysteine utilizing coulometric electrochemical detection: alterations with plasma homocysteine and pyridoxal 5'-phosphate concentrationsQ73406154
Effects of vitamin B-6 on (n-3) polyunsaturated fatty acid metabolismQ73559417
Delta6- and delta5-desaturase activities in the human fetal liver: kinetic aspectsQ77313670
Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological studyQ79734869
Stability of pyridoxal-5-phosphate semicarbazone: applications in plasma vitamin B6 analysis and population surveys of vitamin B6 nutritional statusQ93633948
Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cellsQ24304970
Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acidsQ24532146
A simplified method for analysis of polyunsaturated fatty acidsQ24792478
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
A simple method for the isolation and purification of total lipides from animal tissuesQ25939009
Carnitine biosynthesis. beta-Hydroxylation of trimethyllysine by an alpha-ketoglutarate-dependent mitochondrial dioxygenaseQ28264340
Alteration in the phosphatidylcholine biosynthesis of rat liver microsomes caused by vitamin B6 deficiencyQ28582139
Regulatory Function of Δ6 Desaturase — Key Enzyme of Polyunsaturated Fatty Acid SynthesisQ31203226
Low circulating folate and vitamin B6 concentrations: risk factors for stroke, peripheral vascular disease, and coronary artery disease. European COMAC GroupQ34745701
Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and womenQ36235274
Fatty acid elongases in mammals: their regulation and roles in metabolismQ36431318
Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and womenQ37105818
Vitamin B-6 intake is inversely related to, and the requirement is affected by, inflammation statusQ37474800
PLP-dependent enzymes as entry and exit gates of sphingolipid metabolismQ37895205
Folate deprivation reduces homocysteine remethylation in a human intestinal epithelial cell culture model: role of serine in one-carbon donationQ40616688
Fatty acid uptake and metabolism in Hep G2 human-hepatoma cellsQ41368279
Lipid balance in HepG2 cells: active synthesis and impaired mobilization.Q41439507
New insights into lipid and fatty acid metabolism via stable isotopesQ41573594
A study of the chemical nature of vitamin B(6) and methods for its preparation in a concentrated stateQ42585570
Delta-6-desaturase activity of human liver microsomes from patients with different types of liver injuryQ44044227
Low Vitamin B6 but Not Homocyst(e)ine Is Associated With Increased Risk of Stroke and Transient Ischemic Attack in the Era of Folic Acid Grain FortificationQ44435312
Electroencephalographic and Nerve-Conduction Studies in Experimental Vitamin B6, Deficiency in AdultsQ44824962
Preparation of fatty acid methyl esters for gas-chromatographic analysis of marine lipids: insight studies.Q46559309
Triglyceride Metabolism in Pyridoxine-deficient RatsQ47895855
Electroencephalographic changes and periodontal status during short-term vitamin B-6 depletion of young, nonpregnant womenQ48725896
Homocysteine metabolism and risk of myocardial infarction: relation with vitamins B6, B12, and folate.Q51035720
In vivo evidence for a vitamin B-6 requirement in carnitine synthesis.Q51616681
Plasma glutathione and cystathionine concentrations are elevated but cysteine flux is unchanged by dietary vitamin B-6 restriction in young men and women.Q51822809
Folate and Vitamin B 6 From Diet and Supplements in Relation to Risk of Coronary Heart Disease Among WomenQ57751240
Association of plasma B-6 vitamers with systemic markers of inflammation before and after pyridoxine treatment in patients with stable angina pectorisQ59275989
Low Plasma Vitamin B-6 Status Affects Metabolism through the Kynurenine Pathway in Cardiovascular Patients with Systemic InflammationQ59275991
Dual influence of aging and vitamin B6 deficiency on delta-6-desaturation of essential fatty acids in rat liver microsomesQ63437550
P433issue4
P921main subjectfatty acidQ61476
vitamin BQ183206
hepatocellular carcinomaQ1148337
P304page(s)E342-51
P577publication date2012-12-04
P1433published inAmerican Journal of Physiology - Endocrinology and MetabolismQ15765671
P1476titleVitamin B-6 restriction impairs fatty acid synthesis in cultured human hepatoma (HepG2) cells
P478volume304

Reverse relations

cites work (P2860)
Q35650897Circulating B-vitamins and smoking habits are associated with serum polyunsaturated Fatty acids in patients with suspected coronary heart disease: a cross-sectional study
Q89769324Eicosanoids: Atherosclerosis and cardiometabolic health
Q39015410Folate and vitamin B12 concentrations are associated with plasma DHA and EPA fatty acids in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study.
Q26799534Niacin in the Treatment of Hyperlipidemias in Light of New Clinical Trials: Has Niacin Lost its Place?
Q33839922Targeted metabolomics and mathematical modeling demonstrate that vitamin B-6 restriction alters one-carbon metabolism in cultured HepG2 cells

Search more.