Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction

scientific article published on 22 January 2013

Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/TP.2012.146
P932PMC publication ID3566726
P698PubMed publication ID23340505
P5875ResearchGate publication ID235337616

P50authorWolfgang SadeeQ57715733
P2093author name stringH Zhu
D Sullivan
A C Papp
S Lemeshow
D C Mash
J K Pinsonneault
P2860cites workFinding the missing heritability of complex diseasesQ22122198
Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptorQ24300744
How addictive drugs disrupt presynaptic dopamine neurotransmissionQ24631269
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT geneQ27860482
Distinct functions of the two isoforms of dopamine D2 receptorsQ28138415
The evolutionary significance of cis-regulatory mutationsQ28288545
The mystery of missing heritability: Genetic interactions create phantom heritabilityQ28732355
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving ratsQ29619737
Catecholamine receptor polymorphisms affect decision-making in C. elegansQ30503390
Genetic polymorphisms in the dopamine-2 receptor (DRD2), dopamine-3 receptor (DRD3), and dopamine transporter (SLC6A3) genes in schizophrenia: Data from an association studyQ33505008
Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humansQ33711011
Stimulant abuse: pharmacology, cocaine, methamphetamine, treatment, attempts at pharmacotherapyQ34167229
A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample.Q34574817
Multicenter analysis of the SLC6A3/DAT1 VNTR haplotype in persistent ADHD suggests differential involvement of the gene in childhood and persistent ADHD.Q34661589
Impact of the COMT Val108/158 Met and DAT genotypes on prefrontal function in healthy subjects.Q34661594
Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuseQ34662050
Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorderQ35112181
Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapyQ35654120
Gene-gene interaction associated with neural reward sensitivityQ35781505
Epistatic interactions of AKT1 on human medial temporal lobe biology and pharmacogenetic implicationsQ36253904
Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.Q36300098
Prominence of the dopamine D2 short isoform in dopaminergic pathwaysQ36507451
Genetically determined interaction between the dopamine transporter and the D2 receptor on prefronto-striatal activity and volume in humans.Q37201805
The genetic basis of addiction and relevant cellular mechanismsQ37829267
Functional analysis of intron 8 and 3' UTR variable number of tandem repeats of SLC6A3: differential activity of intron 8 variantsQ39759956
D2 receptors regulate dopamine transporter function via an extracellular signal-regulated kinases 1 and 2-dependent and phosphoinositide 3 kinase-independent mechanism.Q40176514
Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study.Q42539746
No association of the dopamine transporter gene 3' VNTR polymorphism with ADHD subtypes in a population sample of twinsQ43861865
Cocaine induction of dopamine transporter trafficking to the plasma membraneQ43865629
Dopamine transport function is elevated in cocaine usersQ44027693
Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT.Q44748980
National Association of Medical Examiners position paper on the certification of cocaine-related deathsQ44838559
Interacting effects of the dopamine transporter gene and psychosocial adversity on attention-deficit/hyperactivity disorder symptoms among 15-year-olds from a high-risk community sampleQ44985331
The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traitsQ45201727
Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD).Q46636731
Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post-mortem midbrain tissueQ48131633
Loss of autoreceptor functions in mice lacking the dopamine transporterQ48163806
Interactive effects of DAOA (G72) and catechol-O-methyltransferase on neurophysiology in prefrontal cortex.Q51024502
Mapping dopamine transporters in the human brain with novel selective cocaine analog [125I]RTI-121.Q51585551
High affinity cocaine recognition sites on the dopamine transporter are elevated in fatal cocaine overdose victims.Q51617568
Cocaine use increases [3H]WIN 35428 binding sites in human striatum.Q51650264
D2 dopamine receptor gene haplotypes and their influence on alcohol and tobacco consumption magnitude in alcohol-dependent individualsQ80384984
P921main subjectcocaine dependenceQ3743188
P304page(s)e222
P577publication date2013-01-22
P1433published inTranslational PsychiatryQ15716636
P1476titleDopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction
P478volume3

Reverse relations

cites work (P2860)
Q38348213A review of co-morbid tobacco and cannabis use disorders: possible mechanisms to explain high rates of co-use
Q35731672Analyzing allele specific RNA expression using mixture models
Q33854534Association of dopamine gene variants, emotion dysregulation and ADHD in autism spectrum disorder
Q35733219Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion
Q36100262Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?
Q36402504Common variants in DRD2 are associated with sleep duration: the CARe consortium
Q30278827Comparison of dopamine kinetics in the larval Drosophila ventral nerve cord and protocerebrum with improved optogenetic stimulation
Q33599626DRD2/CHRNA5 interaction on prefrontal biology and physiology during working memory
Q39619848Dopamine D3 autoreceptor inhibition enhances cocaine potency at the dopamine transporter.
Q27003334Dopamine and glucose, obesity, and reward deficiency syndrome
Q58115044Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction
Q39309327Gene polymorphisms associated with temperament.
Q38292930Genomic architecture of pharmacological efficacy and adverse events
Q34304684Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric.
Q59807426Introducing Precision Addiction Management of Reward Deficiency Syndrome, the Construct That Underpins All Addictive Behaviors
Q36404935Methods to analyze big data in pharmacogenomics research
Q33676705MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant
Q34212558Missing heritability of common diseases and treatments outside the protein-coding exome
Q64101391Quantification of allelic differential expression using a simple Fluorescence primer PCR-RFLP-based method
Q35849067RNA sequencing of transcriptomes in human brain regions: protein-coding and non-coding RNAs, isoforms and alleles
Q40519250Rapporteur summaries of plenary, symposia, and oral sessions from the XXIIIrd World Congress of Psychiatric Genetics Meeting in Toronto, Canada, 16-20 October 2015.
Q38243174Should we keep on? Looking into pharmacogenomics of ADHD in adulthood from a different perspective.
Q38982760Single nucleotide polymorphisms in the FcγR3A and TAP1 genes impact ADCC in cynomolgus monkey PBMCs
Q33579769The dopamine receptor D2 (DRD2) SNP rs1076560 is associated with opioid addiction
Q54947826The frequency of DRD2 rs1076560 and OPRM1 rs1799971 in substance use disorder patients from the United Arab Emirates.
Q30277983The significant association of Taq1A genotypes in DRD2/ANKK1 with smoking cessation in a large-scale meta-analysis of Caucasian populations
Q42201173Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions
Q64079797Variability in the Drug Response of M Muscarinic Receptor Knockout Mice During Day and Night Time

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