Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

scientific article published on 23 March 2011

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JOCA.2010.08.019
P932PMC publication ID3568396
P698PubMed publication ID21396468
P5875ResearchGate publication ID50374679

P50authorStefan LohmanderQ39752104
P2093author name stringD Heinegård
J Hardin
Y Henrotin
V B Kraus
A R Poole
S Cottrell
S Persiani
J Gardiner
G Matthews
P Garnero
A Ko
R Moskowitz
B Burnett
D Eyre
J Coindreau
M Todman
M Gendreau
J-C Rousseau
J Menetski
OARSI FDA Osteoarthritis Biomarkers Working Group
P2860cites workOptimization of the fixed-flexion knee radiographQ81541543
Feasibility of simultaneous measurement of bone formation and bone resorption markers to assess bone turnover rate in postmenopausal women: an EPOLOS studyQ82771429
Assessment of the utility of biomarkers of osteoarthritis in the guinea pigQ83296983
Association between concentrations of urinary type II collagen neoepitope (uTIINE) and joint space narrowing in patients with knee osteoarthritisQ83925263
A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritisQ78312280
Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritisQ78387194
Kellgren & Lawrence grade 1 osteophytes in the knee--doubtful or definite?Q78849987
Oral salmon calcitonin reduces Lequesne's algofunctional index scores and decreases urinary and serum levels of biomarkers of joint metabolism in knee osteoarthritisQ79158458
Biomarkers and surrogate end points for fit-for-purpose development and regulatory evaluation of new drugsQ79448428
Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiationQ80001948
Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five yearsQ80502383
COMP acts as a catalyst in collagen fibrillogenesisQ80837951
Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY studyQ80845216
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle jointsQ81248117
Use of the plasma stromelysin (matrix metalloproteinase 3) concentration to predict joint space narrowing in knee osteoarthritisQ81300587
Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowingQ81517363
Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]Q24816771
Biomarkers and surrogate endpoints: preferred definitions and conceptual frameworkQ28203935
First qualification study of serum biomarkers as indicators of total body burden of osteoarthritisQ28748487
Radiological assessment of osteo-arthrosisQ29614927
One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis statusQ31157327
A 2 yr longitudinal radiographic study examining the effect of a bisphosphonate (risedronate) upon subchondral bone loss in osteoarthritic knee patientsQ33249982
Serum levels of cartilage oligomeric matrix protein (COMP) increase temporarily after physical exercise in patients with knee osteoarthritisQ33265934
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip.Q33542090
Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled studyQ34001775
Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassayQ34140878
Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: criteria, validation, strategiesQ34192717
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the handQ34196891
Strategic paths for biomarker qualificationQ34750888
Synovial fluid concentrations of the C-propeptide of type II collagen correlate with body mass index in primary knee osteoarthritisQ35547384
Markers of joint destruction: principles, problems, and potentialQ35550491
Content and sulfation pattern of keratan sulfate in hip osteoarthritis using high performance liquid chromatographyQ74067855
Collagen type II C-telopeptide fragments as an index of cartilage degradationQ74514253
Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritisQ35554303
Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in diseaseQ35613010
Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: the GARP studyQ35636890
Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritisQ35637511
Recommendations for the use of new methods to assess the efficacy of disease-modifying drugs in the treatment of osteoarthritis.Q35692131
Cytotoxicity of T-2 toxin and its metabolites determined with the neutral red cell viability assayQ35706718
The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritisQ36274389
Classification of osteoarthritis biomarkers: a proposed approach.Q36491949
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based studyQ36493865
Process map proposal for the validation of genomic biomarkersQ36555934
Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema.Q36753651
Biomarker qualification pilot process at the US Food and Drug AdministrationQ36780044
Monitoring cartilage turnoverQ36793231
Biological markers in osteoarthritisQ36835538
PIIANP and HELIXII diurnal variationQ36884634
Banking of biological fluids for studies of disease-associated protein biomarkersQ36919974
Type II collagen markers in osteoarthritis: what do they indicate?Q36925336
Whole-body bone scintigraphy provides a measure of the total-body burden of osteoarthritis for the purpose of systemic biomarker validationQ36954971
Variation in osteoarthritis biomarkers from activity not food consumptionQ36980483
Trabecular morphometry by fractal signature analysis is a novel marker of osteoarthritis progressionQ37011921
Effect of an exercise and dietary intervention on serum biomarkers in overweight and obese adults with osteoarthritis of the kneeQ37029663
Joint space narrowing and Kellgren-Lawrence progression in knee osteoarthritis: an analytic literature synthesisQ37086756
Serum protein signatures detect early radiographic osteoarthritisQ37154116
The Helix-II epitope: a cautionary tale from a cartilage biomarker based on an invalid collagen sequenceQ37175461
The disease modifying osteoarthritis drug (DMOAD): Is it in the horizon?Q37203491
Collagen biomarkers for arthritis applications.Q37277952
Identification of progressors in osteoarthritis by combining biochemical and MRI-based markersQ37350908
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilageQ37365557
Whither osteoarthritis biomarkers?Q37378390
Evidence for altered synthesis of type II collagen in patients with osteoarthritisQ37388249
Biochemical markers and the FDA Critical Path: how biomarkers may contribute to the understanding of pathophysiology and provide unique and necessary tools for drug developmentQ37462448
Molecular markers of processes in cartilage in joint disease.Q37632518
Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteriaQ37696611
Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthriQ39344079
Glucosamine sulfate and cartilage type II collagen degradation in patients with knee osteoarthritis: randomized discontinuation trial results employing biomarkersQ39367510
Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism AssociationQ39513001
Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritisQ40303620
The Food and Drug Administration's Osteoporosis Guidance Document: past, present, and futureQ40579997
Recommendations for a core set of outcome measures for future phase III clinical trials in knee, hip, and hand osteoarthritis. Consensus development at OMERACT III.Q40900007
Isolation of microarray-grade total RNA, microRNA, and DNA from a single PAXgene blood RNA tubeQ41996281
Novel synovial fluid recovery method allows for quantification of a marker of arthritis in miceQ42060547
Quantification of keratan sulfate in blood as a marker of cartilage catabolismQ42203470
Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report.Q42654166
Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritisQ42909168
Urinary excretion of glucosyl-galactosyl pyridinoline: a specific biochemical marker of synovium degradationQ43564129
Urea as a passive transport marker for arthritis biomarker studiesQ43882922
N-terminal pro-B-type natriuretic peptide concentrations predict the risk of cardiovascular adverse events from antiinflammatory drugs: a pilot trialQ43904300
Analysis of unsaturated disaccharides from glycosaminoglycuronan by high-performance liquid chromatographyQ44311441
Serum concentrations of type II collagen biomarkers (C2C, C1, 2C and CPII) suggest different pathophysiologies in patients with hip osteoarthritisQ44670859
Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate.Q44789264
The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenasesQ45215215
Accumulation of hyaluronate in human lung carcinoma as measured by a new hyaluronate ELISA.Q45928292
Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney diseaseQ46243933
Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: the Johnston County Osteoarthritis Project.Q46357032
Effect of anticoagulants on the determination of plasma matrix metalloproteinase (MMP)-2 and MMP-9 activitiesQ46541397
A study of the relationship between molecular biomarkers of joint degeneration and the magnetic resonance-measured characteristics of cartilage in 16 symptomatic kneesQ46548448
The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradationQ46651873
Reliability of new indices of radiographic osteoarthritis of the hand and hip and lumbar disc degenerationQ46664332
Relationships between biochemical markers of bone and cartilage degradation with radiological progression in patients with knee osteoarthritis receiving risedronate: the Knee Osteoarthritis Structural Arthritis randomized clinical trialQ46907359
Changes in biochemical markers and prediction of effectiveness of intra-articular hyaluronan in patients with knee osteoarthritisQ46939435
Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.Q46939851
Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study.Q48592216
Modulation of collagen fibrillogenesis by dentinal proteoglycans.Q50769440
Circadian variation in serum CrossLaps concentration is reduced in fasting individuals.Q51557915
Plasma hyaluronan concentration: no circadian rhythm but large effect of food intake in humans.Q51566399
Towards complete and accurate reporting of studies of diagnostic accuracy: The STARD Initiative.Q52947167
OMERACT-OARSI initiative: Osteoarthritis Research Society International set of responder criteria for osteoarthritis clinical trials revisited.Q53290466
Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.Q53581205
Associations between joint space narrowing and molecular markers of collagen and proteoglycan turnover in patients with knee osteoarthritis.Q53624861
Blood-based biomarkers for detecting mild osteoarthritis in the human knee.Q54645757
Change in joint space width: Hyaline articular cartilage loss or alteration in meniscus?Q57244844
Serum cartilage oligomeric matrix protein reflects osteoarthritis presence and severity: The Johnston county osteoarthritis projectQ57721652
Soy protein may alleviate osteoarthritis symptomsQ57880747
Early changes in serum type ii collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapyQ59042643
Urinary excretion of pyridinium crosslinks: a new marker of bone resorption in metabolic bone diseaseQ67273045
Early Rheumatoid-Like Lesions in Rabbits Injected with Foreign Serum: Relationship to Localization of Immune Complexes in the Lining Tissues of Joints and Cellular Content of Synovial FluidQ67318046
Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injuryQ67531153
Quantitation of chondroitin 4-sulfate and chondroitin 6-sulfate in pathologic joint fluidQ67588581
Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitorQ73064708
P433issue5
P921main subjectbiomarkerQ864574
osteoarthritisQ62736
P304page(s)515-542
P577publication date2011-03-23
P1433published inOsteoarthritis and CartilageQ7107605
P1476titleApplication of biomarkers in the development of drugs intended for the treatment of osteoarthritis
P478volume19

Reverse relations

cites work (P2860)
Q36241253A 12-week randomized, double-blind, placebo-controlled multicenter study of choline-stabilized orthosilicic acid in patients with symptomatic knee osteoarthritis
Q51296495A dissimilarity-based multiple classifier system for trabecular bone texture in detection and prediction of progression of knee osteoarthritis.
Q91286801A pilot study of peripheral blood DNA methylation models as predictors of knee osteoarthritis radiographic progression: data from the Osteoarthritis Initiative (OAI)
Q37221990Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes
Q35907720Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways.
Q34122276Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis
Q30561348Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.
Q39100190Analysis of the trajectory of osteoarthritis development in a mouse model by serial near-infrared fluorescence imaging of matrix metalloproteinase activities
Q26998936Animal Models of Osteoarthritis: Comparisons and Key Considerations
Q38074887Animal models of osteoarthritis: challenges of model selection and analysis
Q28072990Animal models of osteoarthritis: classification, update, and measurement of outcomes
Q35634979Applications of proteomics to osteoarthritis, a musculoskeletal disease characterized by aging
Q64913227Assessment of early tibiofemoral joint space width changes after anterior cruciate ligament injury and reconstruction: a matched case-control study.
Q64068639Association between changes in molecular biomarkers of cartilage matrix turnover and changes in knee articular cartilage: a longitudinal pilot study
Q47121927Association between ultrasound-detected synovitis and knee pain: a population-based case-control study with both cross-sectional and follow-up data
Q64966958Biomarkers as drug development tools: discovery, validation, qualification and use.
Q27002552Biomarkers for osteoarthritis: current position and steps towards further validation
Q35146138Biomarkers of incident radiographic knee osteoarthritis: do they vary by chronic knee symptoms?
Q34232764Blood cells transcriptomics as source of potential biomarkers of articular health improvement: effects of oral intake of a rooster combs extract rich in hyaluronic acid
Q58570637Bulgarian rheumatology: science and practice in a cost-constrained environment
Q28081433Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use
Q35197151Can we identify patients with high risk of osteoarthritis progression who will respond to treatment? A focus on epidemiology and phenotype of osteoarthritis
Q47375322Cartilage oligomeric protein, matrix metalloproteinase-3, and Coll2-1 as serum biomarkers in knee osteoarthritis: a cross-sectional study.
Q34614103Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254).
Q36111296Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis
Q34078519Cyclic phosphatidic acid relieves osteoarthritis symptoms
Q34554878Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis.
Q33655900Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial
Q42099673Determination of serum biomarkers in osteoarthritis patients: a previous interventional imaging study revisited
Q33669014Discovery of circulating proteins associated to knee radiographic osteoarthritis
Q57141249EUROVISCO Guidelines for the Design and Conduct of Clinical Trials Assessing the Disease-Modifying Effect of Knee Viscosupplementation
Q37658228Effect of age-related cartilage turnover on serum C-telopeptide of collagen type II and osteocalcin levels in growing rabbits with and without surgically induced osteoarthritis
Q36255352Effect of antiresorptive and anabolic bone therapy on development of osteoarthritis in a posttraumatic rat model of OA
Q36156938Effect of chondroitin sulfate on soluble biomarkers of osteoarthritis: a method to analyze and interpret the results from an open-label trial in unilateral knee osteoarthritis patients
Q50459670Effect of oral glucosamine on joint structure in individuals with chronic knee pain: a randomized, placebo-controlled clinical trial.
Q37562358Enhanced expression of the central survival of motor neuron (SMN) protein during the pathogenesis of osteoarthritis
Q38848622Establishment of reference intervals for osteoarthritis-related soluble biomarkers: the FNIH/OARSI OA Biomarkers Consortium
Q49804388Fib3-3 as a Biomarker for Osteoarthritis in a Rat Model with Metabolic Dysregulation.
Q50584701Fractalkine (CX3CL1): a biomarker reflecting symptomatic severity in patients with knee osteoarthritis.
Q58801272GPR120 is an important inflammatory regulator in the development of osteoarthritis
Q55411352Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo.
Q36949072How to define responders in osteoarthritis
Q58628948Identification and validation of early biomarkers of osteoarthritis in companion animals: Are we ready for the challenge?
Q37170273Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis
Q37582530Impact of physical activity and mechanical loading on biomarkers typically used in osteoarthritis assessment: current concepts and knowledge gaps
Q38062383Impact of treatments for osteoporosis on cartilage biomarkers in humans.
Q41555039In vivo efficacy of fresh versus frozen osteochondral allografts in the goat at 6 months is associated with PRG4 secretion
Q41829080In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage
Q33755536Indian hedgehog in synovial fluid is a novel marker for early cartilage lesions in human knee joint
Q26862126Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis
Q87511725Intra-articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect
Q36332977Investigation of random walks knee cartilage segmentation model using inter-observer reproducibility: Data from the osteoarthritis initiative
Q90128829LncRNA DNM3OS promotes proliferation and inhibits apoptosis through modulating IGF1 expression by sponging MiR-126 in CHON-001 cells
Q36422029Magnetic Capture of a Molecular Biomarker from Synovial Fluid in a Rat Model of Knee Osteoarthritis
Q45807411Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
Q35222605Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis
Q36205166Nanomedicines for chronic non-infectious arthritis: the clinician's perspective
Q92594517New Drug Treatments for Osteoarthritis: What is on the Horizon?
Q54987147Nonclinical and clinical pharmacological characterization of the potent and selective cathepsin K inhibitor MIV-711.
Q89870839Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients
Q33947178Novel cartilage oligomeric matrix protein (COMP) neoepitopes identified in synovial fluids from patients with joint diseases using affinity chromatography and mass spectrometry.
Q34475498OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis.
Q26781301On the predictive utility of animal models of osteoarthritis
Q34728871Osteoarthritis year 2010 in review: biochemical markers
Q26771893Osteoarthritis year in review 2015: soluble biomarkers and the BIPED criteria
Q38104445Pathogenesis of epiphyseal osteochondrosis
Q42094646Patient Evaluation and OA Study Design: OARSI/Biomarker Qualification
Q36800983Personalized medicine for osteoarthritis: where are we now?
Q37809746Pharmacologic therapy for osteoarthritis--the era of disease modification
Q47784319Physical activity levels and quality of life relate to collagen turnover and inflammation changes after running
Q47981125Possible Involvement of Serum and Synovial Fluid Resistin in Knee Osteoarthritis: Cartilage Damage, Clinical, and Radiological Links.
Q36403388Predicting Knee Osteoarthritis
Q93135737Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis
Q36050803Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium
Q47358933Predictive value of MRI features for development of radiographic osteoarthritis in a cohort of participants with pre-radiographic knee osteoarthritis-the CHECK study
Q27022211Prognostic biomarkers in osteoarthritis
Q92310100Recent advances in understanding the phenotypes of osteoarthritis
Q33733817Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized
Q52638394Relationship between markers of type II collagen metabolism and tibiofemoral joint space width changes after ACL injury and reconstruction.
Q33900824Relationship between synovial fluid ARGS-aggrecan fragments, cytokines, MMPs, and TIMPs following acute ACL injury: A cross-sectional study
Q38950280Relationship between synovial fluid biomarkers of articular cartilage metabolism and the patient's perspective of outcome depends on the severity of articular cartilage damage following ACL trauma
Q37602869Republished: Value of biomarkers in osteoarthritis: current status and perspectives
Q38723831Review of Soluble Biomarkers of Osteoarthritis: Lessons From Animal Models
Q64099427Revisiting predictive biomarkers of musculoskeletal injury in thoroughbred racehorses: longitudinal study in polish population
Q34379622Running a marathon induces changes in adipokine levels and in markers of cartilage degradation--novel role for resistin.
Q48745658Science in brief: Report on the Havemeyer Foundation workshop on equine musculoskeletal biomarkers--current knowledge and future needs.
Q47151673Scientific Opinion on the substantiation of a health claim related to glucosamine and maintenance of normal joint cartilage pursuant to Article 13(5) of Regulation (EC) No 1924/2006
Q42148121Sequential depletion of human serum for the search of osteoarthritis biomarkers
Q37710696Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair.
Q38869739Societal and Economic Effect of Meniscus Scaffold Procedures for Irreparable Meniscus Injuries.
Q92059853Soluble Biomarkers of Osteoporosis and Osteoarthritis, from Pathway Mapping to Clinical Trials: An Update
Q28077398Soluble biomarkers development in osteoarthritis: from discovery to personalized medicine
Q52639586Subchondral trabecular bone integrity changes following ACL injury and reconstruction: a cohort study with a nested, matched case-control analysis.
Q58734897Superoxide dismutase activity is significantly lower in end-stage osteoarthritic cartilage than non-osteoarthritic cartilage
Q52644417Synovial Fluid Eotaxin-1 Levels May Reflect Disease Progression in Primary Knee Osteoarthritis Among Elderly Han Chinese: A Cross-Sectional Study.
Q37612457TSG-6 activity as a novel biomarker of progression in knee osteoarthritis
Q26850147Targets, models and challenges in osteoarthritis research
Q39783224The Association Between Serum Biomarkers of Collagen Turnover and Subsequent Anterior Cruciate Ligament Rupture
Q42705148The Need for Predictive, Prognostic, Objective and Complementary Blood-Based Biomarkers in Osteoarthritis (OA).
Q27025115The evolving role of biomarkers for osteoarthritis
Q37213622The future of osteoarthritis therapeutics: targeted pharmacological therapy
Q39836529The potential biochemical markers of Kashin-Beck disease: a meta-analysis
Q92828667The role of intra-articular administration of Fetuin-A in post-traumatic knee osteoarthritis: an experimental study in a rat model
Q46644754Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis.
Q37267571Value of biomarkers in osteoarthritis: current status and perspectives.
Q34459809What is the utility of biomarkers for assessing the pathophysiology of hip osteoarthritis? A systematic review.
Q42269793rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

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