CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation

scientific article published on 23 November 2012

CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDD.2012.136
P932PMC publication ID3569983
P698PubMed publication ID23175185
P5875ResearchGate publication ID233750562

P50authorMichael HsiaoQ46884406
P2093author name stringY Eugene Chin
P-C Yang
R-H Chen
M-H Yang
C-C Chang
Y-M Jeng
C-Y Chu
S-T Chen
S-K Lin
M-L Kuo
S-H Pan
B-R Lin
T-C Lai
P2860cites workRecovery of anoikis in Src-transformed cells and human breast carcinoma cells by restoration of the SIRP α1/SHP-2 signaling system.Q53281866
Expression of connective tissue growth factor is in agreement with the expression of VEGF, VEGF-C, -D and associated with shorter survival in gastric cancer.Q53328305
DAP kinase links the control of apoptosis to metastasisQ59083516
Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptorQ71703153
Connective tissue growth factor gene expression alters tumor progression in esophageal cancerQ77811241
Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasisQ80579946
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domainsQ24307661
Functions and mechanisms of action of CCN matricellular proteinsQ24642303
Ubc4/5 and c-Cbl continue to ubiquitinate EGF receptor after internalization to facilitate polyubiquitination and degradationQ24653688
A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulationQ24655468
PID: the Pathway Interaction DatabaseQ24656193
Matuzumab Binding to EGFR Prevents the Conformational Rearrangement Required for DimerizationQ27650259
Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesisQ28252815
Anoikis: cancer and the homeless cellQ28278884
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkBQ28589970
Activated Cdc42 Sequesters c-Cbl and Prevents EGF Receptor DegradationQ28609930
A multigenic program mediating breast cancer metastasis to boneQ29614308
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growthQ33253028
Epidermal growth factor receptors with tyrosine kinase domain mutations exhibit reduced Cbl association, poor ubiquitylation, and down-regulation but are efficiently internalizedQ33779882
Targeting the epidermal growth factor receptor in cancer: apoptosis takes center stage.Q34169176
Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasisQ34302672
Expressions of cysteine-rich61, connective tissue growth factor and Nov genes in hepatocellular carcinoma and their clinical significanceQ36076333
The tumor suppressor DAP-kinase links cell adhesion and cytoskeleton reorganization to cell death regulationQ36386122
Metastasis: recent discoveries and novel treatment strategiesQ36407511
The MET receptor tyrosine kinase in invasion and metastasisQ36868644
CCN2, the connective tissue growth factorQ37031962
Connective tissue growth factor (CTGF) and cancer progressionQ37214721
The epidermal growth factor receptor ligands at a glanceQ37324458
Src kinases as therapeutic targets for cancerQ37604891
Stabilization of an active dimeric form of the epidermal growth factor receptor by introduction of an inter-receptor disulfide bondQ38309484
SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikisQ39627698
The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR.Q40084671
Connective tissue growth factor inhibits metastasis and acts as an independent prognostic marker in colorectal cancer.Q40474669
Epidermal Growth Factor Receptor Activation Differentially Regulates Claudin Expression and Enhances Transepithelial Resistance in Madin-Darby Canine Kidney CellsQ40620861
Levels of expression of CYR61 and CTGF are prognostic for tumor progression and survival of individuals with gliomasQ44418604
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
P2507corrigendum / erratumCorrection to: CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradationQ91304395
P433issue3
P921main subjectcancer metastasisQ120912394
P304page(s)443-455
P577publication date2012-11-23
P1433published inCell Death & DifferentiationQ2943974
P1476titleCCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation
P478volume20

Reverse relations

cites work (P2860)
Q37321763CCN family of proteins: critical modulators of the tumor cell microenvironment.
Q55035206Can insulin-like growth factor 1 (IGF-1), IGF-1 receptor connective tissue growth factor and Ki-67 labelling index have a prognostic role in pulmonary carcinoids?
Q36916437DANGER is involved in high glucose-induced radioresistance through inhibiting DAPK-mediated anoikis in non-small cell lung cancer
Q91473440DAPK1 loss triggers tumor invasion in colorectal tumor cells
Q38212057Deregulated expression of connective tissue growth factor (CTGF/CCN2) is linked to poor outcome in human cancer
Q92756758ERK1/2 communicates GPCR and EGFR signaling pathways to promote CTGF-mediated hypertrophic cardiomyopathy upon Ang-II stimulation
Q48236059Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer.
Q33735255Input of microenvironmental regulation on colorectal cancer: role of the CCN family
Q58712169NADPH oxidase 4 regulates anoikis resistance of gastric cancer cells through the generation of reactive oxygen species and the induction of EGFR
Q35955331Peritoneal expression of Matrilysin helps identify early post-operative recurrence of colorectal cancer.
Q46433404Regulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor
Q37362819Synergistic combination of DT-13 and topotecan inhibits human gastric cancer via myosin IIA-induced endocytosis of EGF receptor in vitro and in vivo

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